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Obesity and diabetes: scientists hunt for hidden clues in body tissues

NCT ID NCT02861781

Knowledge-focused Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin sensitivity. By comparing these groups, researchers hope to identify proteins, genes, and other molecules that play a role in the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal new biological targets for preventing or treating type 2 diabetes in people with severe obesity.
What could go wrong
This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 270 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2016

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subject qualified for bariatric surgery

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Written informed consent 2. Age 18 - 65 years inclusive at surgery 3. IMC \> 35 4. Subject qualified for bariatric surgery (sleeve gastrectomy or gastric bypass) 5. Specific criteria : * Type 2 diabetes group (D) (90 patients) : type 2 diabetes according to ADA criteria * Insulin resistance non diabetes group (IR) (80 patients) : HOMA-IR criteria ≥ 3 * Insulin Sensitivity non diabetes group (N) (100 patients) : N1.HOMA-IR criteria \< 3 Non inclusion Criteria: 1. Vulnerability according to article L1121-6 of the Public Health Code 2. Protected adult or unability to give consent according to article L1121-8 of the Public Health Code 3. Unability to understand the design and aims of the study or to communicate with the investigator 4. Non affiliation to a social security system 5. Prior bariatric surgery (except lap-band procedure) 6. Serologic profile indicating hepatitis B, hepatitis C or HIV infection 7. Inflammatory, infectious or autoimmune disease (current or in the previous 3 month) 8. Malignancies within 5 years prior to inclusion or not considered as treated curatively 9. Concomitant use of steroids or NSAI or use in the 8 days before surgery 10. alcohol abuse/addiction 11. Anticipated poor compliance to study procedures 12. Other type of diabetes than type 2 Exclusion Criteria : 1. Cancelled bariatric surgery 2. Tissue collection not possible during the bariatric surgery

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Conditions

The condition(s) this trial relates to.

Insulin Resistance morbid obesity Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2 Insulin resistance Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Saint Eloi

    RECRUITING

    Montpellier, 34295, France

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