University Hospital, Montpellier

This study tests a new treatment order for people with rheumatoid arthritis who still have active disease despite standard medications. Participants will either receive a TNF inhibitor followed by abatacept, or TNF inhibitors alone. The goal is to see if the two-step approach lea…

This study compares two bone graft materials used during spinal fusion surgery for adults with degenerative disc disease. The goal is to see if a new synthetic material leads to better bone fusion and less disability after surgery. About 100 participants will be followed for 12 m…

This study tests whether placing a small tube (stent) in a narrowed brain vein can lower high pressure inside the skull and improve symptoms like vision loss, headache, and ringing in the ears. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be ran…

This study tests whether adding the drugs atezolizumab and bevacizumab before and after standard radiofrequency ablation can lower the chance of liver cancer returning. About 202 adults with small liver tumors (less than 3 cm) will be randomly assigned to ablation alone or ablati…

This study looks at whether people with early-stage oral or throat cancer can have surgery to remove the tumor and check lymph nodes without staying overnight in the hospital. About 25 adults with small, operable tumors will be treated as outpatients. The main goal is to see how …

This study looks at whether using a lower sodium concentration (140 mmol/l) in dialysis fluid can prevent dangerous fluid buildup in ICU patients with acute kidney injury, compared to the standard higher level (145 mmol/l). About 158 adults on a slow, daily dialysis method will b…

This study tests a chemotherapy cocktail (gemcitabine and oxaliplatin) delivered directly to the liver through a small tube. It is for people with bile duct cancer that has not spread but cannot be surgically removed, and who have already tried one standard treatment. The goal is…

This study looks at whether a hospital stay focused on managing all of a patient's health problems—like high blood pressure, diabetes, and weight—can lower their risk of heart attacks or strokes. About 70 adults at high risk for heart problems will get this personalized care and …

This study is for people with idiopathic intracranial hypertension (IIH) who have had high brain pressure for over a year and haven't gotten enough relief from the drug acetazolamide. The goal is to see if placing a small tube (stent) in a narrowed brain vein can lower the pressu…

This study is for people who have had a stroke caused by a blockage in the main artery in the neck. It compares standard medical treatment alone to standard treatment plus a procedure to open the blocked artery. The goal is to see if the procedure helps more people recover with l…

This study looks at whether having motivational conversations every two weeks for four months after leaving the hospital can help people with alcohol use disorder stay sober longer. About 104 adults who completed alcohol withdrawal in the hospital will be split into two groups: o…

This study tests whether adding addiction monitoring after a liver transplant can reduce the rate of alcohol relapse. About 720 adults who received a liver transplant due to alcohol-related liver disease will be followed for two years. The goal is to see if this extra support hel…

This study tests a new, non-invasive blood test that can detect fetal chromosomal abnormalities as early as 7 weeks into pregnancy. Researchers will collect a blood sample from 25 pregnant women and look for fetal cells to identify genetic issues. The goal is to provide faster, s…

This study tests a new tool that combines a blood test with a questionnaire to help doctors correctly identify bipolar disorder in people who are currently depressed. About 623 adults with depression will give a blood sample and fill out forms. The goal is to see if this tool can…

This study compares two non-drug education programs for people with chronic low back pain. One program teaches about how the brain and nerves process pain (pain neuroscience education), while the other focuses on protecting the spine (back school). The goal is to see which progra…

This study tests whether a newer, directional type of deep brain stimulation can better improve movement problems in people with Parkinson's disease compared to standard stimulation. Ten participants who already have brain electrodes will have their stimulator settings changed to…

This study tests whether it's safe to skip placing a bladder catheter during planned cesarean sections. 550 pregnant women who can urinate on their own before surgery will be randomly assigned to either get the catheter or not. The goal is to see if skipping it leads to more wome…

This study tests a new way to manage breathing during lung cancer surgery. The 'open lung' method adjusts air pressure based on each patient's lung stiffness, aiming to prevent low oxygen levels and lung damage. 120 adults having lung cancer surgery will be randomly assigned to t…

This study tests a new type of talk therapy that helps people with depression correct how they see themselves. It compares this therapy to a standard approach called ACT. The goal is to see if it reduces depression symptoms and prevents relapse over 6 months. About 86 adults with…

This study tests whether daridorexant, a sleep medication, can safely improve sleep in older adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. About 62 participants will take the drug and have their sleep measured in a lab. The …

This study looks at why some women develop endometriosis, a painful condition affecting 1 in 10 women. Researchers will measure body distances and hormone levels in 40 women with and without the disease. The goal is to find early signs that could lead to better understanding and …

This study looks at a protein called BDNF in the spinal fluid and blood of people with Huntington's disease compared to healthy controls. The goal is to find biological markers that can help track the disease and guide future treatments. About 135 adults with confirmed Huntington…

This study looks at whether people with Restless Legs Syndrome (RLS) have overactive nerve signals that can raise blood pressure and heart rate during sleep, possibly increasing the risk of heart disease. Researchers will measure heart nerve activity and track blood pressure over…

This study looks at whether sleep problems are linked to faster memory loss in people with early Alzheimer's disease. Researchers will track 132 participants' sleep patterns and memory over time. If a connection is found, it may lead to earlier sleep treatments to help slow the d…

This study looks at how a woman's surroundings and economic situation might affect her menstrual cycle. Researchers will measure hormones in saliva, track body temperature with a smart ring, and check inflammation levels in 320 women from different backgrounds in southern France.…

This study is testing a new way to remove breast cancer through a small cut in the armpit, leaving no scar on the breast. It is for women with small breasts who need a mastectomy but want to keep their nipple. The goal is to see if this method is safe and works well in a French h…

This study uses special wearable sensors to measure how well people with severe knee osteoarthritis can move their knee before and after getting a total knee replacement. Researchers will track 20 adults over age 60 to find simple movement patterns that could help doctors better …

This study aims to discover new biological factors that lead to type 2 diabetes in people with severe obesity. Researchers will collect tissue samples during planned weight-loss surgery from 270 adults with different metabolic states—some with diabetes, some with insulin resistan…

This study follows 150 people with early hand osteoarthritis to see if imaging techniques like ultrasound and MRI can predict which patients will get worse over time. Participants must be under 60 with symptoms for less than 3 years. The goal is to better understand early signs o…

This study looks at whether parents' exposure to certain chemicals, called endocrine disruptors, might be linked to cryptorchidism (undescended testicles) in baby boys. Researchers will compare the job histories and chemical exposures of parents of boys with and without the condi…

This study compares two ways to perform a lung biopsy in people with interstitial lung disease (a group of lung conditions that cause scarring). One method uses a breathing tube and full anesthesia, while the other keeps the patient awake but numb. The goal is to see which method…

This study follows 400 people with relapsing-remitting multiple sclerosis (MS) for 3 years. Researchers will use MRI scans to measure brain shrinkage and compare those on high-efficacy treatments versus medium-efficacy treatments. The goal is to understand which treatment better …

This study aims to find out how many people are allergic to foods that contain gibberellin proteins, such as peaches, apples, sesame, carrots, lemons, and oranges. Researchers will perform skin prick tests on 2,000 patients at Montpellier University Hospital to measure sensitizat…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, for two years. Researchers will track eye shape, thickness, vision, and tear proteins to see how the disease progresses. Some participants will have no treatment (just advice to avoid ey…

This study aims to improve the accuracy of medical lab tests by creating better reference materials and quality controls. Researchers will compare how these materials behave compared to real patient samples in multiple labs. The goal is to ensure that tests for conditions like ho…

This study tests whether a patient's own stem cells (iPS cells) can repair damaged lung tissue in a lab dish. Researchers will take small lung samples from 50 people—COPD patients, smokers without COPD, and non-smokers—and grow them in the lab. They will then add stem cells to se…

This study looks at whether a specially trained nurse can effectively screen for neurodevelopmental disorders (like delays in learning or behavior) in children aged 1 to 5 who have congenital heart disease. About 270 children will take part. The goal is to see if this screening m…

This study looks at whether a natural cell process called trogocytosis can help predict if CAR-T cell therapy will work for people with a type of blood cancer called diffuse large B-cell lymphoma. Researchers will measure trogocytosis levels in blood samples from 85 patients befo…

This study looks at children with unexplained short stature to find out how many truly have no known cause after a thorough checkup, and then searches for genetic reasons in a small group. About 200 children aged 4 to 18 will get a detailed medical evaluation. The goal is to bett…

This study aims to understand why some heart failure patients choose to join programs like PRADO-IC (home care support) or telemedicine after leaving the hospital. Researchers will follow 700 adults hospitalized for heart failure to see what factors—like social, cultural, or geog…

This study aims to understand how electrical stimulation during awake brain surgery affects brain activity in people with low-grade glioma. Researchers will record brain waves before and after surgery in 12 participants. The goal is to learn more about how stimulation impacts neu…

This study looks at whether chemicals found in everyday products (called endocrine disruptors) increase the chance of a baby boy being born with hypospadias, a condition where the opening of the urethra is not at the tip of the penis. Researchers will compare 100 mothers of boys …

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung health. About 100 children will answer health questions, take allergy tests, and do simple breathing tests. The goal is to understand the combined effect of pollutants and fi…

This study is for people with spinocerebellar ataxia (SCA), a rare genetic disease that affects movement and coordination. Researchers want to find out how often and in what ways the disease also damages the eyes and vision. About 60 adults with SCA types 1, 2, 3, or 27B will get…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of babies born before 28 weeks. Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is to find early warning …

This study aims to better understand how blood flows through skin flaps used in reconstructive surgery. Researchers will measure blood speed, oxygen, and color in 20 adults having flap surgery for pressure sores or limb injuries. The goal is to improve surgical techniques and out…

This study is for adults who have been in a serious accident with broken bones. It will look at medical, personal, and social factors to understand why some people develop lasting pain. The goal is to create a tool that can identify those at risk before they leave the hospital.

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy manage their safety better. 74 participants will be split into two groups: one gets the extra program, the other gets usual care. The main goal is to s…

This study looks at how smoothly people with chronic low back pain can move their spine before and after a rehabilitation program. Researchers will use small body sensors to measure movement quality, not just pain or range of motion. The goal is to find a new way to track recover…

This study aims to understand why some people with chronic leg swelling respond better to compression therapy than others. Researchers will use MRI scans and genetic tests to compare tissue makeup in 48 patients with two different causes of swelling. The goal is to tailor treatme…

This study aims to validate a simple questionnaire that helps doctors and parents understand how well a child's allergy treatment is working. It involves 135 children aged 5 to 11 with allergic rhinitis. The goal is to create a reliable tool to improve treatment satisfaction and …

This study looks at whether the tendency to feel shame can help predict suicide attempts in people with borderline personality disorder (BPD). Researchers will follow 688 adults with BPD for 5 years, tracking their shame levels and any suicide attempts. The goal is to better unde…

This study looks at how a program called VigilanS, which provides regular phone check-ins, helps prevent suicide. Researchers think the program works by restoring social bonds in people who are vulnerable to feeling socially rejected. They will measure stress responses in 120 adu…

This study aims to find specific blood markers that can tell the difference between hepatitis caused by immune checkpoint inhibitors (a type of cancer immunotherapy) and other forms of autoimmune hepatitis. Researchers will compare blood samples from 60 adults with immunotherapy-…

This study compares two self-expanding heart valves used in a procedure called TAVR (transcatheter aortic valve replacement). Researchers want to see which valve works better one month and six months after the procedure. About 419 people who need a new aortic valve and can use a …

This study looks for rare, hard-to-find DNA changes in people with disorders of sex development (DSD) whose genetic cause is still unknown. Researchers will use a new mapping technique on a blood sample from 20 participants. The goal is to better understand the genetic roots of D…

This study is testing whether monitoring a blood marker called sST2 can help doctors better manage heart failure and reduce repeat hospital visits. Researchers will compare costs and quality of life between patients whose treatment is guided by sST2 levels and those receiving usu…

This study aims to find the gene that causes cutis tricolor, a rare skin condition. Researchers will analyze DNA from 10 patients and their parents (affected or not) to identify genetic changes linked to the disease. The goal is to better understand the condition, not to test a t…