University Hospital, Montpellier

This study tests whether a gentler drug, ursodeoxycholic acid (UDCA), works better than standard steroids for treating liver inflammation caused by immunotherapy in cancer patients. About 94 adults with grade 3 or 4 liver injury will be randomly assigned to receive either UDCA or…

This study tests whether people with relapsing-remitting multiple sclerosis (RRMS) who are over 40 and have been stable on strong anti-CD20 drugs for at least 3 years can safely switch to milder treatments without their disease flaring up. Half of the 250 participants will stay o…

This study compares three common surgical techniques for fixing simple hand fractures in adults. About 111 participants will be randomly assigned to receive either a screw, a plate, or pins to hold the bone in place. The goal is to see which method leads to better hand function, …

This early trial tests a one-time CAR T-cell treatment for 6 adults with severe scleroderma that hasn't improved with standard drugs. The goal is to see if it can reduce skin thickening and other symptoms, and to check for side effects. Participants will get the cells by IV after…

This study tests whether adding autobiographical rewriting workshops to standard therapy helps people with borderline personality disorder improve their social and work life. Participants will either rewrite their personal memories or do general writing, alongside cognitive behav…

This study tests a short-term therapy called CFTSI for children aged 7 to 17 who have experienced a traumatic event in the last 3 months. The goal is to see if CFTSI reduces post-traumatic stress symptoms better than standard supportive counseling. 140 children and their parents …

This study tests whether a technique called percutaneous peripheral nerve stimulation (PPNS) can better control pain after shoulder surgery. Sixty adults having shoulder surgery will be randomly assigned to receive PPNS or standard pain management. The main goal is to see if PPNS…

This study looks at whether a 3-week thermal spa treatment can improve knee movement and reduce pain in people with knee osteoarthritis. Researchers will track 300 adults aged 50 and older using motion sensors and pain scales before and after the spa program, and again at 3 and 1…

This study looks at whether a 5-week cardiac rehabilitation program can improve exercise ability and quality of life in 40 adults with cardiac amyloidosis. Participants will complete the program and have tests before and after to measure heart and lung function, symptoms, and wel…

This study tests whether a single injection near the spine (erector spinae plane block) can quickly reduce severe low back pain and help people move better. About 300 adults with sudden, non-specific low back pain will receive either the injection or a placebo. The goal is to see…

This study tests whether a smartphone app called emma, used alongside the standard VigilanS program, can help prevent suicide attempts in adults who have recently tried to take their own life. The app provides daily support, mood tracking, and emergency contacts. Researchers will…

This study looks at 80 children with ADHD to see if differences in their immune system, nutrition, and inflammation levels affect how well they respond to medication. Researchers will compare these kids to those without ADHD and follow them for a year. The goal is to find biologi…

This study looks at how blood flow and energy use in the brain change before and six months after surgery for unruptured arteriovenous malformations (AVMs). Ten adult patients will have special PET scans to measure these changes. The goal is to better understand how the brain rec…

This study looks at how the brain controls sleep in three groups: natural short sleepers (who sleep 6 hours or less), people with idiopathic hypersomnia (who feel very sleepy during the day), and normal sleepers. Researchers will measure brain waves during a 32-hour session to se…

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus samples from 60 patients having sinus surgery—some with pol…

This study looks at 100 adults who had an allergic reaction to contrast dye (used in medical scans) and tested positive on skin tests. Researchers want to see if the allergy remains after a second exposure and what factors might make it last. The goal is to better understand how …

This study looks at babies under 3 months old who have a fever, to find out which viruses might be causing it. Researchers will compare these babies with healthy babies to see if certain viruses are more common in those with fever. The goal is to help doctors tell apart viral and…

This study follows 120 women with twin pregnancies and their 240 babies for one year after birth. Researchers will measure air pollution, diet, lifestyle, and chemical exposures to see how these factors affect birth weight and early development. No treatments or medications are g…

This study aims to find the best way to collect and handle stool samples for analyzing gut bacteria. Researchers will compare different collection methods to see which one gives the most accurate results. Ten healthy adults will provide samples using various devices. The goal is …

This study looks at whether scoliosis surgery can improve nutrition and weight in children with cerebral palsy. Many of these children have trouble eating and are underweight, which raises the risk of complications after surgery. Researchers will measure food intake, body composi…

This study looks at how short-term exposure to everyday workplace noise (below the legal limit) can temporarily affect hearing and thinking. Forty healthy adults aged 18-35 will be exposed to noise with or without quiet breaks. Researchers will measure hearing sensitivity, speech…

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can tell which growths are cancerous and which are harmless. The goal is to find blood-based markers that predict whether the cancer has spread to lymph nodes, helping avoid…

This study tests two different dental glues used to attach braces to teeth. The goal is to see which glue causes less damage (white spots) to the enamel. About 34 teenagers will take part, and each will get both glues on different sides of their mouth for a direct comparison.

This study looks at whether Borderline Personality Disorder (BPD) might be better understood as an addiction to relationships, similar to substance use disorders. Researchers will compare 194 people with BPD, bipolar disorder, and healthy volunteers using questionnaires and tests…

This study looks at whether older adults (75+) with low muscle mass and strength before hip replacement surgery recover more slowly. About 20 volunteers will have their muscle health measured before surgery and be followed for 6 months after. The goal is to learn if pre-surgery m…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find biological patterns that distinguish …

This study looks at 120 teens aged 11-17 who are in a psychiatric hospital, either for suicidal behavior or other mental health reasons. Researchers want to understand how traumatic events affect their recovery and thoughts of suicide. The goal is to learn more about what helps t…

This study tests a program that helps family doctors and pediatricians quickly connect children aged 6-18 with mental health specialists. The goal is to find what makes teamwork among doctors, nurses, and families work best. About 30 healthcare professionals and families will sha…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors—like smoking, diet, or stress—might lead to the disease. Participants include those with high RA antibodies, relatives of RA patients, and newly diagnosed patients. The goal i…

This study aims to find out if tumor cells can be detected in the blood or spinal fluid of people whose aggressive meningiomas have come back. About 15 adults who had surgery for a grade 2 or 3 meningioma will provide blood and spinal fluid samples. The goal is to learn more abou…

This pilot study will track progesterone levels in 40 women after hCG-triggered ovulation to see how the hormone changes over 6 days. The goal is to better understand the luteal phase and when embryos can implant. No treatment is given—only blood tests.

This study will track 60 male athletes who do jumping sports to find early movement changes that may lead to patellar tendinopathy (jumper's knee). Using a camera system without markers, researchers will analyze how athletes jump over a year. The goal is to catch knee problems so…