University Hospital, Montpellier

This study tested whether a single injection of stem cells taken from a patient's own belly fat could help with mild to moderate knee osteoarthritis that hasn't improved with other treatments. About 100 adults received either a low dose, a high dose, or a placebo injection. The m…

This study tested a new way to rebuild the breast after preventive mastectomy in women at high genetic risk for breast cancer. Instead of a scar on the breast and cutting the chest muscle, surgeons used a single-port endoscope through a small incision in the armpit to place the i…

This study tested a smartphone app called EkiYou V2 that helps people with diabetes figure out how much insulin to take. 21 adults with type 1, type 2, or pancreatogenous diabetes used the app for 6 weeks. The app suggested daily insulin doses and adjusted them weekly. Researcher…

This study looked at whether a mobile app can help people with COPD maintain the gains from a 4-week pulmonary rehab program. 200 patients used either the app or standard care for a year. The goal was to see if the app helped them stay active and have a better quality of life ove…

This study tested a program called PRADO for people with heart failure after they leave the hospital. The program helps coordinate doctor visits and nursing care for 2 to 6 months. Researchers wanted to see if it reduces hospital readmissions and is cost-effective. The study incl…

This study looked at whether using a non-invasive breathing mask (NIV) could help patients who develop breathing problems after abdominal surgery avoid needing a breathing tube. 300 adults who had abdominal surgery and then had rapid, shallow breathing were randomly assigned to g…

This study tested whether implanting a new aortic valve without first using a balloon to stretch the old valve is better than the standard approach. 250 patients with severe aortic stenosis who were too high-risk for open-heart surgery took part. The goal was to see if skipping t…

This study tested whether adding a mobile telerehabilitation program to standard CPAP therapy helps obese adults with severe sleep apnea. 180 participants used a smartphone app to guide lifestyle changes and exercise. Researchers measured improvements in daytime sleepiness, quali…

This study looked at whether using a non-invasive breathing mask (NIV) right after removing a breathing tube can prevent serious breathing problems in obese patients in the intensive care unit. About 1000 obese adults who needed a breathing tube for at least 6 hours took part. Th…

This study looked at whether a newer type of dialysis called 'online hemodiafiltration' is better tolerated and reduces heart problems compared to standard high-flux hemodialysis. It involved 415 adults over 65 with advanced kidney failure who had been on dialysis for at least 3 …

This study tested whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) and protect kidney function in 55 adults who had a kidney transplant and have chronic kidney disease. Participants took the drug as prescribed and were followed for 6 months. T…

This study tested whether adding methotrexate to topical steroids for bullous pemphigoid works as well as using topical steroids alone. 322 adults with the disease took part. The goal was to see if the combination treatment is equally effective but easier to manage and with fewer…

This study tested a new way to decide when to give blood transfusions during heart surgery. Instead of using a fixed hemoglobin level, doctors used a measure of oxygen in the blood (SvO2) to guide transfusions. The goal was to see if this approach could safely reduce the number o…

This study looked at whether closer collaboration between doctors and pharmacists could reduce the number of heart failure patients who need to be readmitted to the hospital within three months. Researchers compared standard care to a more coordinated approach involving pharmacis…

This study tested a new, safer way to check for certain genetic diseases during pregnancy using a simple blood draw from the mother. Researchers looked for fetal cells in the mother's blood to diagnose conditions like Huntington's disease and Fragile X syndrome. The goal was to s…

This study tested whether measuring a blood marker called ST2 can improve the diagnosis and management of heart failure patients. Researchers followed 123 hospitalized adults to see if ST2 levels could help predict and reduce the chance of being readmitted within one month. The g…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, instead of the usual spinal fluid test. Researchers tested 342 adults visiting memory clinics. They measured certain proteins in the blood and compared results to standard diagnostic methods. T…

This study aimed to create better diagnostic tools for heart failure with preserved ejection fraction (HFpEF), a type of heart failure that is difficult to diagnose, especially in older adults with conditions like high blood pressure or obesity. Researchers tested a combination o…

This study looked at whether early osteopathic treatment can prevent flat spots on babies' heads (positional plagiocephaly and brachycephaly). About 100 newborns at risk were randomly assigned to receive either osteopathic sessions plus standard advice or just standard advice. Th…

This study tested a simple idea: give women who haven't had a cervical cancer screening in over three years a self-sampling kit to use at home. Researchers recruited 656 women aged 50 to 65 in two French departments with low screening rates. The goal was to see if offering the ki…

This study tested whether patients with schizophrenia or schizoaffective disorder could improve their awareness of their illness by watching a video of themselves recorded during a severe episode. 60 patients participated, with half watching the video after they stabilized. The g…

This study tested a group-based cognitive training program for people with schizophrenia who have had the condition for less than 10 years. The program teaches practical strategies to work around memory, attention, and planning problems. Researchers compared the costs and daily f…

This study tested whether adding a gentle brain stimulation technique (HD-tDCS) to virtual reality therapy could help people who had a stroke more than 3 months ago recover arm function. 58 adults with arm weakness took part. The goal was to see if the combination improved moveme…

This study tested whether a single injection of a patient's own concentrated platelets (PRP) into a damaged spinal disc could reduce pain and improve daily function in people with chronic low back pain. 126 adults with a specific type of disc inflammation (Modic 1) were randomly …

This study tested whether adding a powerful morphine-like drug (Ultiva) to the standard numbing medicine (lidocaine) can make the feticide procedure faster and less painful for the fetus and safer for the mother. The trial involved 66 women undergoing termination of pregnancy aft…

This study tested a 6-week program to help people with chronic diseases improve their quality of life. It focused on those facing economic or social challenges, who often have fewer resources to manage their health. The program taught skills like problem-solving and goal-setting,…

This study tested whether using a virtual reality headset is as good as standard equipment for balance rehab in people with vertigo. 76 adults with vestibular disorders did daily therapy for 3-4 weeks. The goal was to see if the cheaper, smaller VR device could match the standard…

This study tested whether electronic distractions like music, virtual reality, or TV/radio can reduce discomfort in adult ICU patients. Sixty awake, non-delirious patients tried different devices to see if symptoms like pain, anxiety, and thirst improved. The goal is to find safe…

This study tested whether an 8-week mindfulness program (MBSR) can reduce pain and improve daily function in 40 adults with hip or knee osteoarthritis. Participants were randomly assigned to either the mindfulness program or usual care. The main goal was to see if mindfulness tra…

This small pilot study tested whether a mindfulness meditation program could reduce embarrassment from tremor in people with Parkinson's disease. Twenty-one participants were split into two groups: one received meditation training, the other did not. Researchers used questionnair…

This study aimed to find DNA markers (called epigenetic biomarkers) in sputum that could predict how severe lung disease will become in people with cystic fibrosis. Researchers followed 50 participants aged 12 to 30 for 18 months, collecting sputum samples and measuring DNA methy…

This study looked at 20 people with bulimia or binge eating disorder to see if low blood sugar triggers eating binges. Participants wore a continuous glucose monitor and kept a food diary. The goal was to understand how blood sugar levels relate to crisis episodes, which could le…

This study looks at why young women with anorexia nervosa lose bone density. Researchers will compare 160 patients with 160 healthy women to find biological and clinical factors linked to bone loss. The goal is to better understand the process so doctors can improve treatment and…

This study tested a new method using a green dye called indocyanine green (ICG) to help surgeons find small, non-palpable breast tumors during surgery. Ten women with early-stage breast cancer took part. The goal was to see if the dye works as well as the standard radioactive met…

This study looked at 218 people with severe aortic stenosis who needed a heart valve replacement through a tube in their leg (TAVI). Researchers compared two approaches: general anesthesia (being fully asleep) versus local anesthesia with sedation (being awake but relaxed). The g…

This study looked at 1400 adults in intensive care to find out what makes placing a breathing tube (intubation) difficult and what problems can occur. The goal was to identify risk factors so doctors can be better prepared. The study did not test a new treatment, but gathered imp…

This study tested a new approach for people who had a TAVI procedure (a less invasive way to replace a heart valve) and also had blocked heart arteries. The idea was to use a special heart scan (SPECT) after TAVI to decide which blockages needed opening. The study included 71 adu…

This study looked at how in vitro fertilization (IVF) affects the quality of life of working women. Researchers followed 200 women starting their first IVF treatment at a hospital in France, using surveys to measure their emotional, physical, and social well-being over 18 months.…

This study looked at 50 adults with severe asthma who were already taking the drug mepolizumab. Researchers measured the amount of drug in their blood to see if levels differ between people who respond well and those who don't. The goal is to understand why some patients don't ge…

This study looked at the DNA of 60 people with a family history of hypospadias, a condition where the opening of the urethra is not at the tip of the penis. The goal was to find new genetic changes that might cause the condition. By comparing genomes of affected family members, r…

This study looked at whether certain cells found in the blood (circulating epithelial and endothelial cells) could help doctors understand Sjögren's syndrome and scleroderma. Researchers measured these cells in 40 women with either condition. The goal was to see if the number of …

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured markers of oxidative stress (a type of cell damage) in the blood before and after 3 months of CPAP therapy. The goal was to see if CPAP reduces oxidative stress,…

This study looked at whether using a bendable wire (stylet) inside the breathing tube helps doctors place the tube correctly on the first try in critically ill patients. Over 1000 adults in intensive care who needed emergency breathing support took part. The goal was to see if th…

This study aimed to create a personalized 3D computer model of the breast to help surgeons better understand where tumors are located and plan incisions. Researchers measured skin elasticity and thickness in 200 women, and performed additional MRI scans in different positions for…

This study looked at 209 people who had a heart valve replacement (TAVR) and were sent home without a pacemaker. Researchers wanted to see if combining an EKG, a CT scan, and the depth of the new valve could better predict who would later develop dangerous heart rhythm problems n…

This study looked at 72 adults with cystic fibrosis to see if chemical changes in DNA (called DNA methylation) help explain why lung disease gets worse at different rates. Researchers focused on people with a common CF mutation. The goal was to understand how environment and gene…

This study offered a quick hepatitis C test to 1,500 women aged 50-74 who were already coming in for breast cancer screening. The goal was to see how many women would agree to the extra test and to find undiagnosed hepatitis C cases. Women who tested positive were then guided to …

This study looked at muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury affecting arm nerves. Researchers wanted to understand why shoulder muscles become stiff and tested how well these cells can grow and repair. The goal is to build a cell model…

This study looked at 58 people to see if those with an unusual form of multiple sclerosis (MS) have different levels of nerve damage markers in their blood compared to people with classic MS and healthy controls. The goal was to better understand if these atypical cases are a sep…

This study looked at blood samples from 35 people with a rare genetic condition called Acute Necrotizing Encephalopathy Type 1 (ANE1) and compared them to healthy volunteers. The goal was to understand how a mutation in the RANBP2 gene changes the way immune cells react to infect…

This study examined 72 healthy men aged 20-54 who took part in a long-distance triathlon. Researchers used heart ultrasounds and heart monitors to see if intense exercise causes temporary heart changes or rhythm problems. The goal was to better understand the risks of extreme end…

This study tested a new mindful eating program designed for French adults who are overweight or have obesity. The program teaches people to pay closer attention to their eating habits and feelings. Researchers measured changes in mindful eating, anxiety, and depression in 56 part…

This study took blood samples from 4 people with severe asthma or a related condition called ABPA and turned their cells into stem cells. The goal was to grow functional bronchial (airway) tissue in a dish to study how mucus plugs form. The research aimed to validate this lab mod…

This study tested whether a special PET/CT scan could predict delayed brain injury in 35 people who had a bleeding stroke from a ruptured aneurysm. The scan measured early changes in brain blood flow and sugar use. The goal was to see if these measurements could identify patients…

This study looked at 407 people who had a type of heart attack called NSTEMI. Researchers wanted to see if doing a heart procedure (angiography) within 24 hours, as guidelines recommend, leads to better outcomes after 6 months. The goal was to understand how timing affects surviv…

This study looked at 20 years of experience to find the safest and most effective doses for testing penicillin-related drug allergies. Researchers analyzed data from 171 patients with confirmed allergies to beta-lactam antibiotics. They created a new, simpler testing protocol tha…

This study looked at whether regularly measuring the amount of anti-TNF medication and antibodies in the blood helps doctors make better treatment decisions for people with Crohn's disease or ulcerative colitis. 260 patients were split into two groups: one where doctors had acces…

This study tested whether a wrist-worn accelerometer can accurately measure how much stroke survivors use their affected arm during everyday activities. Twenty-five participants wore the device while doing tasks in occupational therapy, and the results were compared to video reco…

This study looked at 43 people with funnel chest (pectus excavatum) to see how their heart and lung function changed after corrective surgery. Researchers measured oxygen use during exercise and asked about symptoms like shortness of breath and quality of life. The goal was to un…