INSULIN RESISTANCE

This study looks at whether drinking a cranberry beverage can help overweight or obese adults improve their blood sugar, insulin levels, and cholesterol. Over 12 weeks, 73 participants will drink either cranberry or a placebo, then switch after a break. Researchers will also chec…

This study tests whether taking a daily oil rich in linoleic acid (an omega-6 fat) for 8 weeks can improve insulin resistance in adults aged 20-60 who already have this condition. Participants will be randomly assigned to receive either the linoleic acid oil or a control oil, whi…

This study looks at whether adding extra fiber to metformin treatment works better than either alone for teens aged 12-18 with severe obesity and insulin resistance. Over 12 months, researchers will measure changes in insulin resistance, weight, and body composition. The goal is …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps people with prediabetes improve blood sugar control and stick to healthy habits better than traditional finger-prick testing. About 80 adults with prediabetes, who are either on diet and exerci…

This study tests whether a daily supplement called Sabroxy® (made from the Oroxylum indicum tree bark) can improve insulin resistance and memory in 140 adults aged 40-80 with mild cognitive impairment and insulin resistance. Participants take either the supplement or a placebo fo…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. Participants receive either MOTS-c or a placebo for 12 weeks, along with lifestyle advice. The main goal is to see if MOTS-c improves how the body uses insulin, which …

This study tests whether metformin, a drug already used for diabetes, can help obese, non-diabetic people lose weight and reduce their risk of heart disease. Researchers will give 220 Black Nigerian adults either metformin or a placebo for several months. The goal is to see if me…

This early-phase study at Vanderbilt University is testing whether a natural substance called angiotensin-(1-7) can improve how the body uses insulin in people with obesity, insulin resistance, and high blood pressure. About 26 adults aged 18-60 will receive the peptide or a plac…

This study looks at whether treating depression with an online therapy program can improve how the body uses insulin in people with HIV who are on HIV medication. About 150 adults with HIV and depression will either receive 9 weeks of internet-based cognitive behavioral therapy o…

This study tests whether taking sodium bicarbonate (baking soda) can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will take the supplement and undergo tests like e…

This study tests if replacing sugary sodas with unsweetened flavored sparkling water can reduce added sugar intake and improve health in Black and Latine teens with obesity who love sweet drinks. Over 8 weeks, participants will drink study beverages, complete taste tests, and pro…

This study tests whether taking glutamine, a natural amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in people with severe obesity. About 110 participants will receive either glutamine or a placebo powder. The goal is to s…

This study tests whether electro-acupuncture can improve insulin resistance in people with obesity. Sixty adults aged 21-65 with a BMI of 25 or higher and signs of insulin resistance will be randomly assigned to receive either real electro-acupuncture or a sham (fake) version. Re…

This study looks at whether taking a multi-strain probiotic alongside healthy lifestyle changes can improve liver health in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a common fatty liver condition. About 80 adults with signs of liver damage wil…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at whether taking short walks after meals or doing quick 'activity snacks' can help breast cancer survivors control their blood sugar better than a standard 30-minute walk. The researchers will compare these strategies in 24 women who have had breast cancer and a…

This study tests whether a 10-week telemedicine exercise program can improve cardiorespiratory fitness and insulin resistance in Asian children aged 12-17 with low fitness. Participants will either join weekly online exercise sessions or follow standard activity recommendations. …

This study looks at how antipsychotic drugs change the way the brain responds to insulin in women, and whether this varies with menstrual cycle phase. Fifteen healthy women will receive the antipsychotic olanzapine or a placebo, plus insulin nasal spray, and undergo MRI scans. Th…

This study looks at how different types of insulin resistance affect the liver's fat production in people with high triglycerides. Researchers will measure fat production after a meal and see if a short exercise session before eating changes it. The goal is to understand the link…

This study looks at what happens to muscle size, strength, and blood sugar control when healthy young adults stay in bed for 5 days. Researchers will measure changes using MRI, strength tests, and muscle biopsies. The goal is to better understand how quickly muscle loss and insul…

This study aims to learn how much insulin the body actually needs to keep blood sugar normal. Ten adults with obesity and high insulin levels will take a drug called diazoxide for eight days to temporarily stop insulin production. Researchers will measure their fasting blood suga…

This study explores what happens to your body's cells and metabolism during a long fast. Researchers will take blood samples from 15 healthy adults before, during, and after a prolonged fast. They will then test how that blood affects breast cancer cells in a lab dish, to see if …

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8 to 12 who may be at higher risk for PCOS. Participants will either get a full program with coaching and messages or a lower-intensity version with mess…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see which factors—like insulin resistance or inflammation—are linked to changes in memory, proce…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—relates to the health of the placenta and the risk of complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate ris…

This study aims to discover new biological factors that lead to type 2 diabetes in people with severe obesity. Researchers will collect tissue samples during planned weight-loss surgery from 270 adults with different metabolic states—some with diabetes, some with insulin resistan…

This study is testing a new, radiation-free imaging technique called photoacoustic imaging to look at brown adipose tissue (BAT), a type of 'good' fat that burns energy. Researchers will compare BAT activity in 100 healthy adults and people with metabolic syndrome, both at rest a…

This study looks at how blood sugar levels change throughout the day in women with polycystic ovary syndrome (PCOS). PCOS is a common hormone condition that raises the risk of insulin problems and type 2 diabetes. Researchers will use a small sensor to track glucose continuously …

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat sends out signals that make your muscles less responsive to insulin, and if weight loss can quiet those signals. About 70 adults with obesity will fo…

This study looks at how different types of fat affect how muscles respond to insulin. Healthy adults will receive infusions of palm oil or a fat emulsion through a tube into the small intestine overnight. Researchers will then take muscle samples to see how the fats are processed…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that could explain why some groups face higher risks for metabolic problems. No…

This study looks at how ketone bodies—chemicals your liver makes when you fast or exercise—affect how your body uses energy and responds to insulin. Ten overweight adults aged 55–70 will each try four different treatments (including a ketone drink and a placebo) on separate days.…

This study looks at whether eating more slowly digesting starch and resistant starch can improve blood sugar control and reduce inflammation in people with insulin resistance. Forty adults with insulin resistance will follow a special diet for two months. Researchers will track b…

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. The goal is to measure changes in insulin sensitivity, fitness, and overall he…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study looks at how the gut's fermentation process affects insulin resistance in teenagers and young adults with obesity. Researchers will give a sugar drink (lactulose) to see how it changes fat breakdown and sugar production in the body. The goal is to better understand the…

This study looks at how diabetes changes the way heart cells use energy, which may lead to heart failure. Researchers will examine heart tissue and use imaging tests in 500 adults with heart failure, with or without type 2 diabetes. The goal is to better understand the disease an…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…