INSULIN RESISTANCE

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study tests whether empagliflozin, a medicine used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Insulin resistance is common in bipolar disorder and may worsen mood symptoms. The study will involve 20 adults over …

This study looks at whether a type of talk therapy for insomnia (CBT-I) can also improve metabolic health, including insulin resistance and blood sugar. Twenty adults with insomnia and higher body weight will be randomly assigned to CBT-I or basic sleep tips for 5 weeks. Research…

This study will measure two proteins, SCUBE-1 and SCUBE-3, in the blood of women with polycystic ovary syndrome (PCOS) and compare them to healthy women. The goal is to see if these proteins are linked to inflammation and future heart problems. About 56 women aged 18-35 will take…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be assigned to one of four groups and consume a sweetener or wat…

This study aims to find new signs in muscle cells that help explain insulin resistance, a condition where the body doesn't respond well to insulin. Researchers will compare muscle samples from 36 adults, including lean individuals and those with obesity, using advanced techniques…

This study looks at whether a combined exercise program can help reduce chronic pain in postmenopausal women. Researchers think insulin resistance might be a key link between metabolism and pain. They will measure pain levels, blood markers, and body changes in 50 women who are n…

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance and fatty liver disease. About 36 adults with overweight or obesity will undergo two procedures where insulin is either kept high or lowered by half. …

This study looks at how losing sleep and having out-of-sync body clocks can make it harder for the body to use insulin properly, a condition called insulin resistance. Researchers will test 48 healthy adults aged 18-45 to see how the stress hormone cortisol affects this process. …