INSULIN RESISTANCE

This study tests whether a low dose of the drug everolimus can safely improve signs of aging in people aged 55 to 80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in metabolism, heart function,…

This study tests if giving children a carbohydrate drink before elective surgery can prevent or reduce insulin resistance, a condition where the body doesn't use insulin well. About 50 healthy kids (ASA I-II) having surgery under general anesthesia will be randomly assigned to re…

This study looks at whether adding less sitting time to regular exercise can improve heart and metabolic health more than exercise alone. About 30 adults with desk jobs who sit over 9 hours a day will either exercise only or exercise plus reduce sitting. Researchers will measure …

This study looks at whether a healthy diet and exercise program can help people with pulmonary arterial hypertension (PAH), a serious lung condition. The idea is that improving how the body handles sugar (insulin sensitivity) might also improve blood flow in the lungs. About 34 a…

This study looks at whether eating 1.5 cups of fresh mango every day for 12 weeks can help control blood sugar, cholesterol, and inflammation in adults with prediabetes. About 31 participants will eat mango for 12 weeks, take a break, then avoid mango for another 12 weeks so rese…

This study tests whether a daily avocado supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo for 16 weeks, while researchers track changes in body weight, blood glucose, and other heal…

This study is testing a digital health platform called STELA that helps adults without heart disease lower their risk factors like obesity, high cholesterol, and insulin resistance. About 100 participants will get a full health check, a personalized prevention plan, and support t…

This study tests whether metformin, a common diabetes medicine, can prevent muscle loss and insulin resistance in healthy adults aged 60 and older during five days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The goal is to see if metformi…

This study tests whether a 24-week program combining aerobic exercise, cognitive training on a mat, and turmeric (with black pepper) can prevent cognitive decline in people aged 55-70 who have insulin resistance and memory concerns. Participants will be randomly assigned to recei…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma control and insulin resistance in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, inflammation, and breathing tests. Only 7 participants are enrolled…

This study looks at whether insulin resistance (when the body doesn't respond well to insulin) can predict how well a heart procedure called pulsed field ablation works for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their firs…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance and weight loss. Researchers will analyze fat samples from 50 people having weight-loss surgery. The goal is to understand why some people with …

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with high blood pressure. Researchers will measure heart and artery health after low-salt and high-salt diets. About 120 adults with mild to moderate hypertension will participate. The goal i…

This study aims to find which people with psoriasis are more likely to develop insulin resistance, a condition that can lead to diabetes and heart disease. Researchers will analyze medical records from over 1,200 patients to build a simple, understandable tool that doctors can us…

This study was designed to test whether taking essential amino acids plus arginine for eight weeks could improve liver fat, insulin sensitivity, and body composition in obese children aged 7-10. However, the study was withdrawn before enrolling any participants, so no results are…

This study looks at how a substance made by gut bacteria, called TMAO, might affect insulin resistance (a step toward diabetes). Researchers will give 40 healthy adults L-carnitine supplements and also have them do a simulated night-shift to see how these factors change blood mar…

This study follows 50 obese patients (BMI over 32) aged 16-60 who are having weight-loss surgery. Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure fat in the pancreas and check how well the pancreas is working. The goal is to see…

This study looks at how eating chestnuts affects blood sugar and insulin levels after a meal in healthy adults. Researchers want to see if chestnuts, which are high in fiber and starch, can help manage blood sugar better. Fifteen adults will eat chestnuts and then have their bloo…

This study looks at how fructose, a type of sugar, contributes to fat production and high blood sugar after meals. Researchers will track these processes in 35 adults who have prediabetes or insulin resistance, as well as healthy controls. The goal is to better understand the mec…

This study looks at why some people with obesity develop health problems like diabetes and heart disease while others don't. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 people with obesity. The goal is to u…

This pilot study looks at how daily consumption of erythritol (a sugar substitute) versus regular sugar affects insulin resistance and blood clotting in healthy adolescents aged 14-18. Researchers will also check for any digestive issues and measure blood levels of erythritol. Th…

This study was designed to see if taking fish oil before exercise could help reduce inflammation in people with obesity. Researchers planned to measure changes in blood markers and gut bacteria over 6 weeks. However, the study was withdrawn before any participants were enrolled, …

This study aims to understand how bariatric surgery improves the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. By studying these samples, they hope to learn the molecular signa…

This study uses a small device called a continuous glucose monitor (CGM) to track blood sugar levels in women with PCOS over 10 days. Researchers want to see how blood sugar patterns differ in PCOS and whether using the CGM can help improve metabolic and reproductive health. Abou…

This study looks at how insulin in the brain changes blood flow and nerve activity in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, and nerve signals to muscles. No treatment is given—this is an observation-only study to better understand h…

This study looks at how the tightening of blood vessels (called sympathetic vasoconstriction) may reduce the ability of insulin to widen blood vessels and take up sugar. Researchers will test this by temporarily blocking the tightening signal in the forearm of 36 adults with obes…

This study looks at how losing a small amount of weight (5% of body weight) changes insulin and testosterone levels in overweight women with insulin resistance. Researchers will measure these hormones before and after a weight loss diet. The goal is to understand the link between…