INSULIN RESISTANCE

This study is testing whether a specific diet and exercise program can help people with pulmonary arterial hypertension (PAH) by improving how their bodies process sugar (insulin sensitivity). Researchers believe this approach might help control the underlying disease process. Th…

This study aimed to see if giving obese children a drink containing amino acids for eight weeks could reduce fat in their liver and improve how their body processes fats and proteins. It was designed as a controlled trial where neither the children nor the researchers would know …

This study is testing whether a dietary supplement made from avocados can help overweight adults manage their weight and blood sugar levels. For 16 weeks, 60 participants will take either the supplement or a placebo pill while following basic diet and exercise guidelines. Researc…

This study is testing whether eating 1.5 cups of fresh mango every day for 12 weeks can help improve health markers in adults with prediabetes. Researchers are measuring changes in blood sugar, cholesterol, inflammation, and body composition. Participants will eat mango daily for…

This study is testing whether a low dose of a drug called everolimus, taken daily or weekly for 24 weeks, can safely improve signs of aging in older adults who have insulin resistance (a pre-diabetic condition). Researchers will measure changes in metabolism, heart health, brain …

This study aims to see if combining regular exercise with efforts to sit less during the workday improves heart and metabolic health better than exercise alone. It involves about 30 adults with desk jobs who sit for long periods. Participants are assigned to either an exercise pr…

This small, early-stage study is exploring whether taking a daily probiotic supplement for 12 weeks can help improve asthma control and reduce insulin resistance in obese adults who have both conditions. Researchers will measure changes in gut and airway bacteria, body weight, in…

This study is testing whether a combined program of physical exercise, cognitive training, and a turmeric supplement can help prevent cognitive decline in adults aged 55-70 who have insulin resistance, a known risk factor for dementia. One hundred participants will follow the pro…

This early-stage study is testing if the diabetes medication metformin can help prevent muscle loss and insulin resistance in healthy adults aged 60+ during short periods of bed rest. Researchers want to see if taking metformin before and during five days of bed rest can protect …

This study aims to better understand blood sugar patterns in women with Polycystic Ovary Syndrome (PCOS) using a wearable glucose monitor. Researchers will first track glucose levels in women with and without PCOS. Then, they will test if using the monitor for 90 days, along with…

This study aims to understand why some people with high blood pressure are more sensitive to salt in their diet. Researchers will observe 120 adults with mild hypertension, putting them on low-salt and high-salt diets while monitoring their heart and blood vessel function. The go…

This study aims to understand how weight-loss surgery helps improve type 2 diabetes in obese patients. Researchers will use MRI scans and blood tests to measure fat in the pancreas and insulin function before and after surgery. The goal is to see if reducing pancreatic fat leads …

This study aims to understand how a specific diet and weight loss affect key hormones in women. Researchers are testing if an 8-week Mediterranean-style diet, designed to help participants lose 5% of their body weight, lowers insulin and testosterone levels. The study involves wo…

This research aims to understand how weight loss surgery helps improve diabetes and metabolism by studying tissue samples from patients. Researchers will collect small samples of fat, muscle, liver, and intestine during scheduled medical procedures like endoscopies and surgeries.…

This study aims to understand why some people with obesity develop related health problems like diabetes while others stay healthy. Researchers are comparing three popular weight-loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants with obesity. Th…

This study aims to create a tool that helps doctors predict which people with psoriasis are more likely to develop insulin resistance, a silent condition that raises the risk of diabetes and heart disease. Researchers will use existing medical records from over 1,200 patients to …

This study aims to understand how nerve signals that tighten blood vessels might contribute to insulin resistance, a condition common in obesity. Researchers will test if temporarily blocking these nerve signals in the arm improves blood flow and the body's ability to use insulin…

This small, withdrawn pilot study aimed to understand if taking fish oil supplements while doing high-intensity exercise could work together to reduce harmful inflammation linked to obesity. Researchers wanted to see if fish oil improved gut bacteria, which might make exercise mo…

This study aims to understand how a substance produced by gut bacteria might influence insulin resistance, a condition that can lead to diabetes. Researchers will give 40 healthy volunteers either a supplement or a placebo for 12 weeks and simulate night-shift work for some parti…

This study is testing whether eating chestnuts affects how the body handles sugar after a meal. Fifteen healthy adults will eat chestnuts and have their blood sugar and insulin levels measured. The goal is to gather basic information on chestnuts' health effects to see if they co…

This early research study aims to understand how insulin affects blood flow to the brain and nervous system activity in healthy adults. Researchers will measure brain and leg blood flow, as well as nerve signals, in 65 participants aged 18-45. The study is currently suspended and…