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Can a Low-Carb diet tame insulin and testosterone in overweight women?

NCT ID NCT06998238

First seen Mar 24, 2026 · Last updated Jun 23, 2026 · Updated 10 times

Summary

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight. Researchers will measure changes in fasting hormones and insulin sensitivity to understand how weight loss affects these factors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • University of Missouri

    Columbia, Missouri, 65211, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Mediterranean-based, carbohydrate-restricted, calorie-reduced diet

What this could lead to

If successful, this study could clarify how weight loss affects insulin and testosterone levels in women with insulin resistance.

What could go wrong

This is a very small early-stage study with only 8 participants, so results may not apply to the broader population.

Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder Overweight polycystic ovary syndrome Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.