University Of Missouri-columbia

This study tests whether clavulanic acid, a drug used to boost antibiotics, can help people smoke less. Thirty adult smokers will take either the drug or a placebo for several weeks. Researchers will measure smoking levels and use brain scans to see if the drug changes how the br…

This study tests whether adding a pre-surgery scrub with isopropyl alcohol and chlorhexidine soap to the standard cleaning routine can lower the number of germs on the skin and reduce infections after elective foot and ankle surgery. About 100 adults having planned foot or ankle …

This study looks at a new bone graft material called Fibergraft Aeridyan Matrix for treating open pilon fractures, which are severe breaks in the lower leg that often get infected or don't heal well. Researchers will follow 45 adults who need bone grafting as part of their standa…

This study looks at two different surgical methods to fix a specific type of broken thigh bone (distal femur fracture). The goal is to see which method helps the bone heal more completely, reducing the need for additional surgeries. About 100 adults who need surgery for this inju…

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after bariatric surgery leads to greater weight loss and better blood sugar control. About 150 adults with severe obesity and related conditions will either stay on or stop these meds around the tim…

This study tests whether empagliflozin, a drug used for diabetes, can reduce age-related stiffening of arteries in healthy older adults. Researchers will give 80 men and women aged 60-80 either the drug or a placebo for 12 weeks. The goal is to see if the drug improves artery fle…

This study looks at whether eating grape powder can improve gut health and reduce inflammation in adults with obesity. Researchers will measure changes in gut bacteria, immune markers, and stress levels. The study involves 50 participants aged 30-45 with a BMI between 30 and 45. …

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study is testing whether a powerful 7T MRI scan can detect tiny brain metastases earlier than standard 1.5T/3T scans in people with small-cell lung cancer who choose not to have preventive brain radiation. Twenty participants will get a 7T brain scan followed by up to a year…

This study looks at whether taking antibiotics for just one day after a cat bite to the hand or forearm works as well as the usual five-day course, or even a placebo. About 72 adults who are bitten and seek care within 24 hours will be randomly assigned to one of three groups. Th…

This study tests whether a single injection of N-acetylcysteine (NAC), a common amino acid, can prevent cartilage cell death after a severe ankle fracture (pilon fracture). About 30 adults with this injury will receive either NAC or a placebo during their initial surgery. The goa…

This study tests whether rinsing the surgical area with a steroid (dexamethasone) during herniated disc surgery can lower pain and disability afterward. About 200 adults with a single-level lumbar disc herniation who have not improved with rest or therapy will be randomly assigne…

This study tests whether a whole-body electrical muscle stimulation suit can help adults with neuromuscular diseases like ALS, muscular dystrophy, and myasthenia gravis exercise safely. Because these conditions weaken muscles and nerves, traditional exercise is often too hard. Th…

This study tests a group-based self-management program delivered via telehealth for people who had a mild or moderate stroke within the last 6 months. The program teaches problem-solving and goal-setting skills to improve daily activities and community participation. Researchers …

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and daily function in 15 people with mild traumatic brain injury (mTBI) who have trouble sleeping. Participants will learn techniques like sleep scheduling and changing unhelpful tho…

This pilot study tests whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve nerve-muscle communication and physical function in healthy older adults. Twelve participants will use a special suit with electrodes that stimulate major muscle gr…

This study looks at whether low-impact group exercise classes can reduce pain in people with knee, hip, or ankle osteoarthritis. Participants will attend exercise sessions three times a week for six months, along with standard diet and behavioral health support. The study aims to…

This study tests a brief skills-based program called Show Me FIRST to help teens with PKU (a rare genetic condition) manage anxiety and depression. Thirty adolescents aged 10-17 will be randomly assigned to start the program right away or after a wait period. The goal is to see i…

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) strategies to improve daily tasks and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will participate. The goal is to…

This early-phase study at the University of Missouri-Columbia is looking at how aging and menopause affect the way blood vessels widen in response to low oxygen levels. Researchers will measure blood flow in the forearm of 75 women who are premenopausal, perimenopausal, or postme…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic disorder, to track how the condition changes over time. Participants will undergo brain scans, EEGs, and genetic testing, and complete developmental assessments. The goal is to create better tool…

This early-phase study aims to understand why women after menopause have a higher risk of heart disease. Researchers will measure how the nervous system controls blood flow in 75 women aged 18-70, using two drugs (propranolol and phentolamine) to temporarily block certain nerve s…

This study looks at whether showering 48 hours after breast reconstruction surgery, while drain tubes are still in place, raises the risk of infection. It also checks how showering affects quality of life. About 100 women having implant-based breast reconstruction will take part.…

This study looks at how lactate, a brain fuel, affects blood flow in the brain. Researchers will compare people with and without obesity, and test if short-term exercise training can improve lactate levels and brain blood flow in those with obesity. 24 healthy adults aged 18-45 w…

This study looks at how blood flow and the nervous system adapt early in aging women. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand these changes, not to test a treatment.

This study follows 40 adolescents and young adults with back stress fractures to see how these injuries heal naturally over a year. Participants get several MRI scans and answer pain questionnaires. The goal is to learn when it's safe to return to sports by watching the bone brid…

This study looks at what happens to blood pressure when healthy adults sleep only 4 hours a night. Researchers will compare normal-weight and obese participants to see if lack of sleep affects their blood pressure differently. The goal is to better understand the link between sle…

This study aims to understand why people with type 1 diabetes face a higher risk of heart attacks and strokes. Researchers will compare fat and protein metabolism in 30 adults—half with type 1 diabetes and half healthy controls—using special tracer infusions and blood tests. The …

This study looks at how insulin-making beta-cells react to growth hormone in women who had gestational diabetes. Researchers will compare these women to those without a history of the condition. The goal is to learn more about what causes gestational diabetes, not to test a new t…

This study looks at how different types of protein—from animals or plants, and as whole foods or isolates—affect blood sugar control and insulin sensitivity in people with metabolic syndrome. Researchers will measure glucose levels and insulin action over 24 hours. The goal is to…

This small study looks at how a 6-month family-focused program of healthy eating and activity affects thinking skills (like focus and planning) in teens ages 13-17 who are overweight or have obesity. Ten teens and a parent or guardian will attend group sessions and complete tests…

This study collects samples from 320 people, including those with solid cancers (like lung, colon, or pancreatic cancer) and those undergoing lung cancer screening, to look for cancer cells and DNA in blood, urine, and bone marrow. The goal is to learn how cancer spreads and find…

This study aims to learn more about rare genetic disorders that affect brain development, like Baker Gordon Syndrome and Syt-1 disorder. Researchers will collect medical data, genetic samples, and other information from 100 participants (ages 0-99) and their caregivers. The goal …

This study looks at whether eating a lot of protein, especially from animal sources, can make heart disease worse. Researchers will study blood samples from 24 adults aged 45-75 who are overweight but otherwise healthy. The goal is to understand how protein affects immune cells a…

This study collects blood and bone marrow samples from 50 adults with blood cancer to learn more about a protein called DPP4. Researchers hope this will help them understand how the cancer grows and find better treatments. Participants will not receive any experimental therapy.

This study tests a remote training program for autistic teens and young adults (ages 13-21) and their primary caregiver. The program teaches strategies to improve thinking and daily life skills. The goal is to see if the program is practical and helpful for participants.

This study looks at adults who carry the gene for phenylketonuria (PKU) but do not have the disease. Researchers want to see if their brains handle phenylalanine differently and if it affects thinking or brain activity. Participants will take phenylalanine or a placebo, then have…

This study looks at blood, urine, and bone marrow samples from 620 people with solid cancers (like lung, colon, or pancreatic cancer) to find and measure tumor cells and DNA. The goal is to better understand how cancer spreads and returns after surgery. Participants include cance…