University Of Missouri-columbia

This study tests whether adding a pre-surgery scrub with alcohol and chlorhexidine soap to the usual skin cleaning can lower the number of surgical site infections in adults having elective foot or ankle surgery. About 100 participants will be split into two groups: one gets the …

This study looks at whether people who take GLP-1 medications (like Ozempic or Wegovy) should continue them after bariatric surgery. Researchers want to see if staying on the drug leads to more weight loss, better blood sugar control, and changes in gut health. About 150 adults w…

This study tests whether clavulanic acid, a medication often used with antibiotics, can reduce smoking in adults who smoke more than 10 cigarettes daily. About 30 participants will receive either the drug or a placebo, and researchers will measure changes in smoking behavior and …

This study looks at two different surgical methods to fix a broken bone just above the knee (distal femur fracture). The goal is to see which method helps the bone heal better and lowers the chance of needing another surgery. About 100 adults who need surgery for this type of bre…

This study looks at whether eating grape powder can improve gut health and immune function in adults with obesity. Researchers will measure changes in gut bacteria, inflammation, and stress levels. The study involves 50 participants aged 30-45 with a BMI between 30 and 45. Partic…

This study tests whether a daily pill called empagliflozin (a type of SGLT2 inhibitor) can reduce stiffening of arteries that happens with age. The trial will include 80 healthy adults aged 60-80 who have some artery stiffness but no diabetes or major heart disease. Participants …

This study is testing whether a very powerful 7T MRI machine can find tiny brain metastases earlier than standard 1.5T or 3T MRI scans. It involves 20 adults with small-cell lung cancer who have chosen not to receive preventive brain radiation. The goal is to see if the 7T MRI ca…

This study tests whether injecting N-Acetylcysteine (NAC) into the ankle joint shortly after a severe fracture can protect cartilage cells from dying. About 30 adults with high-energy pilon fractures will receive either NAC or a placebo during their staged surgery. The goal is to…

This study looks at whether antibiotics prevent infections from cat bites on the hand or forearm, and how long they should be taken. About 72 adults who were bitten within the last 24 hours will be randomly assigned to receive either a placebo, a 1-day course, or a 5-day course o…

This study tests a special training program to help breast cancer survivors who have memory and thinking problems after treatment. The training teaches strategies to improve daily activities like remembering tasks and staying focused. Researchers will check if the program is prac…

This study is testing whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, muscular dystrophy, and myasthenia gravis exercise safely. Because these conditions make normal exercise hard, the WB-EMS suit directly stimulates…

This study tests a small-group, video-based program for people who had a mild or moderate stroke within the last 6 months. The program teaches skills to manage daily activities and improve confidence. Researchers will measure changes in activity performance, satisfaction, and qua…

This study tests a brief skills-based program called Show Me FIRST to help teens aged 10-17 with PKU reduce anxiety and depression. 30 participants will be randomly assigned to start the program right away or after a waiting period. The goal is to see if the therapy improves mood…

This study looks at how lactate, a brain fuel, affects blood flow to the brain in people with and without obesity. Researchers will measure brain blood flow and lactate levels during exercise in 24 healthy adults. The goal is to understand if short-term exercise training can impr…

This study is testing a new remote training program designed to help autistic teenagers and young adults improve their thinking and planning skills, with support from a parent or caregiver. The program involves 24 pairs (teen and caregiver) and aims to see if it is practical and …

This study collects blood and bone marrow samples from 50 adults with blood cancers like leukemia. Researchers want to understand how a protein called DPP4 affects cancer growth. The goal is to find better, personalized treatments in the future. Participants provide samples but d…

This study looks at how insulin-making cells in the pancreas react to growth hormone in women who had gestational diabetes. Researchers want to understand why some women later develop type 2 diabetes. The study involves 30 women with a history of gestational diabetes or healthy p…

This study aims to learn more about rare genetic disorders that affect brain development, such as Baker Gordon Syndrome and Syt-1 disorder. Researchers will collect medical information, genetic samples, and other data from 100 participants of all ages. The goal is to track how th…

This study looks at how the nervous system and blood vessels change as women age. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand early signs of aging in the body's blood flow system.

This study looks at how getting less sleep than usual affects blood pressure. Researchers will monitor 45 healthy adults, including those with normal weight and obesity, to see changes. The goal is to better understand the connection between sleep and heart health, not to provide…

This study looks at adults who carry the gene for phenylketonuria (PKU) but do not have the disease. Researchers want to see if their brains handle the amino acid phenylalanine differently than people without the gene. Participants will take phenylalanine or a placebo, then under…

This study aims to find cancer cells and DNA in the blood, urine, and bone marrow of people with solid cancers (like lung, stomach, or colon cancer) and those being screened for lung cancer. By measuring these markers, researchers hope to better understand how cancer spreads and …