University Of Missouri-columbia

This study tests whether a daily pill called empagliflozin (a diabetes drug) can reduce stiffening of arteries that happens with age. Researchers will give the drug or a placebo to 80 healthy adults aged 60-80 for 12 weeks and measure changes in artery stiffness. The goal is to s…

This study looks at whether eating grape powder can improve gut health and reduce inflammation in adults with obesity. Researchers will measure changes in gut bacteria, immune markers, and stress levels. The study involves 50 participants aged 30-45 with a BMI between 30 and 45. …

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study looks at two common surgical methods for fixing a broken bone just above the knee (distal femur fracture). The goal is to see which method helps the bone heal more completely, reducing the need for additional surgeries. About 100 adults who need surgery for this type o…

This study looks at whether adding an extra cleaning step before foot and ankle surgery can lower the risk of infection. About 100 adults having elective foot or ankle surgery will take part. Half will get the standard skin cleaning, and half will get an extra scrub with alcohol …

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to keep taking the drug or s…

This study looks at a new bone graft material called Fibergraft Aeridyan for treating severe open ankle fractures. These fractures have high risks of infection and slow healing. The study will follow 45 adults for 12 months to see if the material helps bones heal better and reduc…

This study compares a powerful 7T MRI to standard 1.5T/3T MRI scans to see if it can detect very small brain metastases earlier in people with small-cell lung cancer who choose not to have preventive brain radiation. About 20 participants will receive both types of scans over tim…

This study tests whether injecting N-Acetylcysteine (NAC) into the ankle shortly after a severe fracture can prevent cartilage cell death and reduce the risk of post-traumatic arthritis. About 30 adults with high-energy pilon fractures will receive either NAC or a placebo injecti…

This study looks at whether antibiotics are needed after a cat bite to the hand or forearm, and if so, for how long. About 72 adults who were bitten within the last 24 hours will be randomly assigned to receive either a placebo, one day of antibiotics, or five days of antibiotics…

This study tests a small-group, video-based self-management program for people who had a mild or moderate stroke within the last 6 months. The program helps participants build skills and confidence to improve daily activities and quality of life. About 100 adults aged 45–85 will …

This study looks at whether low-impact group exercise classes can reduce pain in people with knee, hip, or ankle osteoarthritis. Participants will attend exercise classes three times a week for six months, along with standard diet and behavioral health support. The goal is to see…

This study is testing whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, muscular dystrophy, or myasthenia gravis exercise safely. Because these conditions make voluntary exercise difficult, WB-EMS uses electrical pulse…

This study tests whether clavulanic acid, a medication used in some antibiotics, can help adult smokers reduce their cigarette intake. Thirty participants will receive either the drug or a placebo and will have brain scans to see how their brain responds to smoking-related images…

This study tests a brief skills-based program called Show Me FIRST to help teens with PKU (a rare genetic condition) manage anxiety and depression. Thirty adolescents aged 10-17 will be randomly assigned to start the program right away or after a wait period. The goal is to see i…

This study tests a training program that teaches breast cancer survivors with memory and concentration problems (brain fog) strategies to improve daily tasks and quality of life. About 50 women who finished cancer treatment 6 months to 3 years ago will participate. The goal is to…

This study looks at whether giving a steroid during surgery for a herniated disc in the lower back can reduce pain and disability afterward. About 200 adults will be randomly assigned to receive either the steroid or a placebo during their operation. Researchers will track pain s…

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep, reduce brain injury symptoms, and help people with mild traumatic brain injury (mTBI) get back to their daily activities. Researchers will enroll 15 adults with mTBI and sleep probl…

This study looks at how the nervous system and blood vessels change as women age. Researchers will measure blood flow in the forearm of 64 women aged 18-70. The goal is to better understand early signs of aging in the body's blood vessels.

This study looks at how blood vessels in the arm widen when oxygen is low, and how this changes with menopause. Researchers will compare younger premenopausal women, perimenopausal women, and older postmenopausal women. No treatment is given; the goal is simply to understand the …

This study follows 50 children and adults with Baker Gordon Syndrome, a rare genetic condition causing developmental delays, autism traits, and seizures. Researchers will collect medical history and track symptoms over time to better understand the disease. The goal is to create …

This study looks at why people with type 1 diabetes have a higher chance of heart attacks and strokes. Researchers will compare how the body processes fats and proteins in 30 adults with and without diabetes. Participants receive a special amino acid infusion to track these proce…

This study looks at whether eating a lot of protein, especially from animal sources, can make heart disease worse. Researchers will study blood samples from 24 adults aged 45-75 who are overweight but otherwise healthy. The goal is to understand how protein affects immune cells a…

This study looks at how beta-cells (which make insulin) respond to growth hormone in people with a family history of type 2 diabetes. Researchers will compare these responses between 30 adults with obesity who either have or don't have a family history of the disease. The goal is…

This study follows 40 adolescents and young adults (ages 12-30) with pars stress fractures in the lower back. Participants get multiple MRI scans over a year to see how the bone heals. The goal is to learn if MRI can show when the fracture has fully bridged, helping doctors decid…

This study looks at how different types of protein (from animals or plants, and as whole foods or isolates) affect blood sugar control and insulin sensitivity in adults with metabolic syndrome. Researchers will measure blood sugar levels over 24 hours and how well the body respon…

This small study looks at whether a 6-month family-focused weight management program can improve thinking skills (like focus and self-control) and weight in teens ages 13-17 who are overweight or have obesity. Ten teens and their caregivers will attend group sessions and complete…

This study looks at how a substance called lactate affects blood flow in the brain. People with obesity often have trouble processing lactate, which may impact brain health. Researchers will compare brain blood flow in 24 adults with and without obesity, and test if short-term ex…

This small pilot study looks at whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve how nerves activate muscles in older adults. The researchers will measure changes in muscle firing and physical function after 8 sessions over 4 weeks. The…

This study collects blood and bone marrow samples from 50 adults with blood cancer to learn more about a protein called DPP4. Researchers hope this will help them understand how the cancer grows and find better treatments. Participants will not receive any experimental therapy.

This study tests a remote training program for autistic teens and young adults (ages 13-21) and their primary caregiver. The program teaches strategies to improve thinking and daily life skills. The goal is to see if the program is practical and helpful for participants.

This study looks at adults who carry the gene for phenylketonuria (PKU) but do not have the disease. Researchers want to see if their brains handle phenylalanine differently and if it affects thinking or brain activity. Participants will take phenylalanine or a placebo, then have…

This study aims to learn more about rare genetic disorders that affect brain development, such as Baker Gordon Syndrome and Syt-1 disorder. Researchers will collect medical information, genetic samples, and other data from 100 participants (both affected individuals and their car…

This study looks at blood, urine, and bone marrow samples from 620 people with solid cancers (like lung, colon, or pancreatic cancer) to find and measure tumor cells and DNA. The goal is to better understand how cancer spreads and returns after surgery. Participants include cance…

This study looks at how getting less sleep than usual affects blood pressure in healthy adults. Researchers will compare people of normal weight and those with obesity, aged 18 to 45. Participants will have their sleep shortened and their blood pressure measured to see if there i…

This study collects samples from 320 people, including cancer patients and those undergoing lung cancer screening, to measure tumor cells and DNA in blood, urine, and bone marrow. The goal is to learn more about how cancer spreads and to improve early detection and personalized t…

This study is for women who have had first-stage breast reconstruction with tissue expanders and surgical drains. It compares showering 48 hours after surgery versus not showering to see if showering increases the chance of infection. Researchers will also check how showering aff…

This study looks at how insulin-making beta-cells react to growth hormone in women who had gestational diabetes. Researchers will compare these women to those without a history of the condition. The goal is to learn more about what causes gestational diabetes, not to test a new t…

This study looks at how the nervous system and blood vessels interact in women going through menopause. The goal is to understand why aging women face a higher risk of heart disease. Researchers will measure nerve activity and blood flow in 75 women aged 18-70. No treatment is gi…