University Of Missouri-columbia

This study planned to test whether a 14-day ketogenic diet before heart bypass surgery could reduce confusion and memory loss in adults aged 60 and older. The diet was thought to lower brain inflammation and improve brain cell health. However, the study was withdrawn before any p…

This study tests whether virtual follow-up visits are as safe and effective as standard in-person appointments after surgery for a broken wrist. About 160 adults who have had wrist fracture repair and own a smartphone or computer will be randomly assigned to either remote monitor…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests whether giving a mix of three medicines (methadone, dexmedetomidine, and ketamine) during complex spine surgery can lower pain and reduce the need for opioid painkillers afterward. About 248 adults aged 18 to 79 having surgery on three or more spine levels will t…

This study tests an intensive group physical therapy program for children aged 7-17 with cerebral palsy who can walk. The program focuses on building leg strength, power, and walking ability through exercises like leg presses and stair climbing. Researchers will measure improveme…

This study tests if giving a standard amount of IV fluids before surgery can prevent low blood pressure after anesthesia in people having a cystoscopy. About 100 adults will take part. The goal is to see if this simple step reduces the risk of blood pressure drops during the proc…

This study looks at why overweight adults with sleep apnea have a higher risk of blood sugar problems and diabetes. Researchers will compare people with and without sleep apnea, and test whether using a CPAP machine or just extra oxygen at night can improve how the body handles s…

This study looks at how eating pulses like beans and lentils changes the bacteria in your gut and affects your appetite. Researchers will measure gut microbes, appetite hormones, and other health markers in 44 overweight adults. Participants will eat a special diet and provide bl…

This study aimed to see if adding telehealth sessions to in-person physical therapy helps children with moderate to severe disabilities improve daily skills at home more than in-person therapy alone. It planned to include children ages 2 to 17 and measure changes in function and …

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.

This study looks at whether wearable rings and shift data can help understand why nurses get burned out. Fifty nurses from intensive care and surgery units will wear Oura Rings and fill out surveys. The goal is to find patterns that lead to burnout so hospitals can better support…

This study looks at how high-protein drinks affect certain blood cells (monocytes and platelets) that may play a role in heart disease. Ten healthy adults will drink either a low-protein, high-protein, or leucine-added meal, and researchers will check their blood for changes in c…

This early-stage study looks at whether sirolimus, an FDA-approved drug, can increase blood flow to the brain in healthy adults aged 45-65. Some participants carry a gene (APOE4) that raises Alzheimer's risk, while others do not. The goal is to understand how the drug affects bra…

This study looks at how cannabis use changes the amount of anesthesia needed during lumbar spine surgery and how it affects inflammation and wound healing. Researchers will compare 210 adults who use cannabis with those who do not, measuring anesthetic doses and blood markers of …

This study looks at why some people with obesity have normal blood sugar while others do not. Researchers will measure how much sugar fat and muscle tissues take up in people with and without insulin resistance. About 90 adults will participate, including lean and obese individua…

This study looks at how losing a small amount of weight (5% of body weight) changes insulin and testosterone levels in overweight women who have insulin resistance. Researchers will measure these hormones before and after a diet plan. The goal is to understand the link between we…