Cat bite antibiotics: could less be more?
NCT ID NCT05846399
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking antibiotics for just one day after a cat bite to the hand or forearm works as well as the usual five-day course, or even a placebo. About 72 adults who are bitten and seek care within 24 hours will be randomly assigned to one of three groups. The goal is to see if shorter treatment can prevent infections without increasing harm.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Amoxicillin/clavulanate (or alternatives ciprofloxacin and clindamycin)
- What this could lead to
- If successful, this could show that a shorter course of antibiotics or even no antibiotics is safe after a cat bite, reducing unnecessary medication and side effects.
- What could go wrong
- This is a small, early-phase trial with only 72 participants, so results may not apply to everyone. There is a risk that shorter treatment or placebo leads to more infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2023
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients greater or equal to 18 years of age. * Bitten by a cat. * Location of bite is the hand and/or forearm (distal to elbow). * Presenting \<24 hours following a cat bite to the hand/forearm. * English speaking Exclusion Criteria: * Patients who present with active local or systemic infections 1. Purulent drainage from the cat bite 2. Redness AND swelling at the location of the cat bite * Having a fever \>100.4° F or \>38° C)-Received antibiotics within the past 30 days * Received antibiotics within the past 30 days * Patients unwilling to take study medication * Patients unwilling to attend scheduled follow-up evaluations or complete study forms * Pregnant Women * Type I hypersensitivity reaction to any of the study interventions * Immunocompromised patients (primary and secondary immunodeficiencies) Primary * Autoimmune Lymphoproliferative Syndrome (ALPS) * Autoimmune Polyglandular Syndrome type 1 (APS-1) * B-cell Expansion with Nuclear factor kappa-light-chain-enhancer of activated B cells and T-cell Anergy (BENTA) Disease * Caspase Eight Deficiency State (CEDS) * Caspase Recruitment Domain Family Member 9 (CARD9) Deficiency and Other Syndromes of Susceptibility to Candidiasis * Cartilage-hair hypoplasia * Chédiak-Higashi syndrome * Chronic Granulomatous Disease (CGD) * Common Variable Immunodeficiency (CVID) * Complement Deficiencies * Congenital Neutropenia Syndromes * Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) Deficiency * Cyclic neutropenia * DiGeorge syndrome * Dedicator Of Cytokinesis 8 (DOCK8) Deficiency * GATA-binding protein 2 (GATA2) Deficiency * Glycosylation Disorders with Immunodeficiency * Hyper-Immunoglobulin E Syndromes (HIES) * Hyper-Immunoglobulin M Syndromes * Interferon Gamma, Interleukin 12 and Interleukin 23 Deficiencies * Leukocyte Adhesion Deficiency (LAD) Types 1 and 2 * Lipopolysaccharide Responsive Beige-Like Anchor Protein (LRBA) Deficiency * Phosphatidylinositol 3-kinase (PI3-Kinase) Disease * Phospholipase C gamma 2 (PLCG2) associated Antibody Deficiency and Immune Dysregulation (PLAID) * Severe Combined Immunodeficiency (SCID) * Selective Immunoglobulin A (IgA) deficiency * Signal transducer and activator of transcription 3 (STAT3) Dominant-Negative Disease * STAT3 Gain-of-Function Disease * Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome * Wiskott-Aldrich Syndrome (WAS) * X-Linked Agammaglobulinemia (XLA) * X-Linked Lymphoproliferative Disease (XLP) * X-linked magnesium transporter 1 (MAGT1) deficiency with increased susceptibility to Epstein-Barr virus (EBV) infection and N-linked glycosylation defect (XMEN) Disease * Zeta-associated protein 70 (ZAP-70) deficiency Secondary * Malnutrition * Uncontrolled Diabetes mellitus * Chronic uremia * Genetic syndromes: trisomy 21 * Immunomodulatory, immunosuppressive drug therapy: corticosteroids, calcineurin inhibitors, cytotoxic agents * Systemic lupus erythematosus * Malignancy * Active radiation therapy * Bone marrow ablation * Infectious diseases: human immunodeficiency virus (HIV) infection, Hepatitis Additional Primary and secondary immunodeficiencies can be found at the following link. https://www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/overview-of-immunodeficiency-disorders
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Missouri
RECRUITINGColumbia, Missouri, 65212, United States
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