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Salt and genes: new study probes why some blood pressure patients are Salt-Sensitive

NCT ID NCT01426529

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of angiotensin II. The goal is to understand why some people are salt-sensitive, which could lead to better, more personalized ways to manage hypertension.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Para-aminohippuric acid and angiotensin II
What this could lead to
If successful, this study could help explain why some people with high blood pressure are salt-sensitive, potentially pointing toward more personalized treatments.
What could go wrong
This is an early-phase observational study, not a treatment trial. It is designed to gather knowledge, not to test a new therapy, so there is no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2010

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 18-65 * mild to moderate hypertension * no other major illnesses * BMI \< or equal to 40 Exclusion Criteria: * secondary illnesses * BMI \> 40 * taking 4 or more anti-hypertensive medications * BP \>160/100 on screening exam * Alcohol intake \>12 oz per week * Current smoking * Recreational drug use * use of birth control pills or contraceptive hormone shots

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension Insulin resistance

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.