Brigham And Women's Hospital

This study tests whether a drug called sacubitril/valsartan can help people who just started hemodialysis. The goal is to see if it reduces fluid buildup in the heart and helps preserve any remaining kidney function. About 100 adults will receive either the drug or a placebo for …

This study tests whether a higher daily dose of radiation over three weeks can help older adults (65+) with newly diagnosed glioblastoma live longer and with fewer side effects compared to the standard dose. About 56 participants will be randomly assigned to one of two radiation …

This pilot study tests whether repeated sessions of low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite trying at least two medications will receive the ultrasound treatment. …

This study is testing whether a uterus from a deceased donor can be safely transplanted into women who cannot get pregnant due to a missing or non-working uterus. Participants will first have their eggs harvested and embryos frozen, then receive a donor uterus. After recovery, an…

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces a key marker of kidney damage…

This study tests a program called OPTIONS that helps older adults recover after a broken hip or leg. The program provides exercise, diet advice, and bone-strengthening medication in nursing homes and after going home. About 1,500 people aged 65 and older will take part. The goal …

This study explores whether a uterus transplant can help 10 women with absolute uterine infertility (no uterus or one that doesn't work) have a baby. Participants will go through IVF, receive a donated uterus, attempt pregnancy, and deliver by C-section. After childbirth, the ute…

This study tests a nasal spray called Foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray is designed to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and be follo…

This study is testing a new type of surgery for people who have had a leg amputated. The goal is to help them better control their residual limb, restore a sense of where the limb is in space (proprioception), and reverse muscle wasting. The study will enroll 26 adults who alread…

This study tests a new oral drug called BRS201 in 20 adults with severe ulcerative colitis who have not improved with standard treatments. Participants take the drug twice daily for 4 weeks and attend 8 clinic visits over 12 weeks. The goal is to see if BRS201 can reduce disease …

This study compares two common diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) to see which is better at preventing heart attacks, strokes, kidney failure, and death in people with type 2 diabetes who already have or are at high risk for heart disease. About 6…

This study aims to help pregnant women and their babies in rural Guatemala by providing food supplements and behavioral counseling. The goal is to reduce both maternal obesity and child stunting in the same household. About 1,532 pregnant women aged 16 and older will take part.

This study tests whether semaglutide (the drug in Ozempic/Wegovy) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking buprenorphine. About 46 adults will receive either semaglutide or a placebo injection weekly for 12 weeks. Researche…

This study tests a new way to start treatment for opioid use disorder using a single long-acting injection of buprenorphine. Thirty adults who use opioids will stay in the hospital for 3 days, receive the injection, and be closely monitored for withdrawal symptoms. The goal is to…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart strain and size using ultrasound. The trial enrolls 20 adults aged 21-80 with moderate to severe kidney dise…

This small pilot study is testing whether tirzepatide, a drug used for diabetes, can help people with alcohol use disorder reduce their cravings for alcohol. Twenty adults will receive weekly injections of either tirzepatide or a placebo for 4 weeks. The goal is to see if the dru…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study looks at 450 adults with multiple myeloma who have a type of kidney damage called light chain cast nephropathy. Researchers want to see if plasma exchange or a drug called daratumumab helps the kidneys recover better than other treatments. The goal is to improve surviv…

This study looks at whether a type of blood pressure medication called a mineralocorticoid receptor antagonist can improve blood flow in the small vessels of the heart and make the heart pump more efficiently. Researchers will compare it to a standard diuretic in 75 adults with h…

This study tests whether the drug BRS201 (a form of vitamin B12) can lower liver enzyme levels in people with primary sclerosing cholangitis (PSC), a chronic liver disease. About 28 adults with PSC will take the drug or a placebo for 4 weeks each, in random order, and have their …

This study tests a new surgical method for arm amputations that may allow people to better control advanced prosthetic limbs and regain feeling in the missing limb. Researchers will perform the modified surgery on 10 participants and compare their results to 10 others who had sta…

This study tests whether joining a support club helps people with HIV stick to their medication and keep the virus under control. Participants either join a club where they pick up 6 months of medicine and get peer support, or receive standard clinic care. The goal is to see if t…

This study tests a drug called elranatamab in people with AL amyloidosis that has come back or not responded to prior treatment. The goal is to find a safe dose and see if the drug can reduce abnormal protein levels in the blood. About 49 adults will take part in this early-phase…

This study tests a new portable chest X-ray machine that takes moving images (15 frames per second) right at the bedside in the ICU. Researchers want to see if it gives doctors better information about lung and diaphragm function compared to standard X-rays. About 230 adults with…

This study tests a new type of PET scan (18F-DCFPyL-PSMA) to see how well it shows prostate cancer in 30 men with advanced disease who are already scheduled for a targeted radiation therapy. The goal is to compare this scan with the standard one to see if it detects cancer spots …

This study tests a new AI-assisted platform called IntelliWell that can identify rare sperm cells in testicular tissue samples from men with non-obstructive azoospermia (no sperm in ejaculate). Instead of discarding tissue that appears sperm-free under standard analysis, the plat…

This study tests whether a special PET scan can detect blood clots inside the heart of people with cardiac amyloidosis and atrial fibrillation. Twenty participants will receive an injection of a tracer that binds to clots, then undergo a combined PET/MRI scan. The goal is to see …

This study tests a new needle holder frame for MRI-guided prostate biopsy in 15 people with suspected prostate cancer. The goal is to see if the frame helps doctors take tissue samples more accurately from suspicious spots seen on MRI. If successful, this tool could make biopsies…

This study tests a new way of using MRI scans to tell the difference between a brain tumor that has come back and harmless scar tissue caused by radiation. About 101 people with brain tumors that grew after focused radiation will get this special scan before any surgery. The goal…

This study will enroll 1000 adults aged 35-85 with chest pain or shortness of breath to see if measuring blood flow in detail during a stress MRI can more accurately diagnose heart disease than standard imaging. Researchers hope this approach helps doctors better understand the s…

This study tests whether a special PET scan using 18F-fluciclovine can better detect advanced prostate cancer that doesn't show up well on standard PSMA scans. About 30 people with metastatic prostate cancer that has low PSMA levels or neuroendocrine features will get the scan an…

This study tests whether a computer alert can remind doctors to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. About 400 adults aged 40 and older with medical conditions like heart failure or infection will take part. The goal is to preven…

This study tests whether an artificial intelligence (AI) tool can help doctors spot calcium buildup in the heart arteries from chest CT scans done for other reasons. The goal is to start or increase cholesterol-lowering medicine in people aged 40–75 who have no prior heart diseas…

This study looks at whether regularly flushing a nephrostomy tube (a tube that drains urine from the kidney) with salt water helps prevent it from getting blocked. About 20 adults who have or will get a nephrostomy tube will be randomly assigned to either flush the tube routinely…

This study tests a prevention bundle for hospital patients at high risk of getting a C. difficile infection. The bundle includes identifying patients who carry the germ without symptoms and then giving them personalized care to prevent them from getting sick or spreading it to ot…

This study tests whether giving high doses of magnesium before and during surgery can prevent kidney damage caused by the chemotherapy drug cisplatin. About 130 adults with mesothelioma will receive either magnesium or a placebo. The goal is to see if magnesium helps keep kidneys…

This study tests a pill called oral treprostinil in 30 adults with severe Raynaud's phenomenon that hasn't improved with usual medicines. Raynaud's causes fingers and toes to change color and become painful in cold or stress. Participants will take the pill three times daily for …

This early-phase trial is testing whether a shorter, more intense course of radiation is safe for people with a rare cancer called retroperitoneal sarcoma. The study will enroll 6 participants and closely monitor side effects like nausea, vomiting, and diarrhea within 30 days of …

This study aims to find out if a shorter insomnia treatment works as well as a longer one for adults who are socioeconomically disadvantaged. 350 participants will receive either tele-Brief Behavioral Treatment for Insomnia or tele-Cognitive-Behavioral Therapy for Insomnia. The g…

This study tests whether giving oxytocin (a natural hormone) through an IV during surgery can reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. About 152 adults having this surgery will be randomly assigned to receive either oxytocin or a pl…

This study tests a faster version of transcranial magnetic stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for 6-8 weeks, this accelerated TMS gives multiple treatments each day for just 5 days. The study will enroll 24 people to…

This study tests a new, faster version of transcranial magnetic stimulation (TMS) for post-traumatic stress disorder (PTSD). Instead of daily sessions for 6-7 weeks, participants receive 10 imaging-guided treatments per day for just 5 days. The goal is to see if this accelerated …

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep more easily. Thirty adults with long-term sleep problems will be split into three groups: one using the app with guided meditation, one using the app without g…

This study compares three common insomnia treatments—two medications (trazodone and daridorexant) and an online behavioral program—in 1,000 women aged 40-62 who are in or near menopause. Participants will take their assigned treatment for 12 months, wear a Fitbit, keep a sleep di…

This study tests whether two medications—Pyridostigmine and Low-Dose Naltrexone—can improve daily functioning in people with ME/CFS or Long COVID who also have orthostatic intolerance (trouble standing). 160 adults aged 18-70 will be randomly assigned to take one or both drugs or…

This study tests whether yoga can help people manage persistent pain that lasts months after torso surgery. Researchers will enroll 50 adults who have had surgeries like chest, breast, or abdominal operations and still feel moderate pain. Participants will take yoga classes or at…

This study tests if Acceptance and Commitment Therapy (ACT), a type of talking therapy, can help adults with chronic migraine do more of their daily activities. About 40 people will either get ACT plus their usual care, or just usual care. Over a year, they'll answer questions an…

This early-phase trial tests whether combining atomoxetine with a new hypnotic drug, DAW2022, can reduce the severity of obstructive sleep apnea (OSA) in 18 adults with moderate-to-severe OSA. The goal is to find a better-tolerated alternative to current treatments by measuring b…

This study tests a positive psychology program called PATH for people who have had a stem cell transplant. The goal is to see if it can reduce anxiety and depression and improve quality of life. About 400 adult survivors will be randomly assigned to the program or usual care, and…

This study tests whether men recovering from robotic prostate surgery can manage pain without automatically receiving opioid painkillers. Participants are counseled on pain management and then randomly assigned to either receive a standard opioid prescription plus other pain medi…

This study tests whether taking losartan for 30 days after multi-ligament knee surgery helps people regain motion, strength, and return to work or sport. About 90 adults with severe knee injuries will be randomly assigned to receive losartan or a placebo. The goal is to reduce in…

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This study tests a procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with long-lasting shoulder pain from rotator cuff tendinopathy. About 41 participants will either get TAE plus physical therapy or physical therapy alone. The g…

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study is for adults aged 40-79 with rheumatoid arthritis who have at least one heart disease risk factor (like high blood pressure or smoking). It aims to find better ways to detect early signs of heart disease using heart scans and blood tests. The goal is to identify high-…

This study explores whether playing music, with or without a parent's voice, can lower stress and improve brain development in very preterm infants (born 24-30 weeks). About 243 babies from two hospitals will be randomly assigned to music, music plus parent voice, or standard car…

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to temporarily change brain activity in healthy adults. Researchers want to understand how a part of the brain called the cerebellum helps control feelings of fullness and food choices. 1…

This study uses a special PET scan to measure brain inflammation in people with multiple sclerosis or Alzheimer's disease, compared to healthy volunteers. Researchers aim to see if the pattern of inflammation differs between these diseases and relates to symptom severity. Up to 2…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study looks at whether routine brain MRIs can find cancer that has spread to the brain in people with metastatic or inflammatory breast cancer. About 214 participants will get screening MRIs to see how often brain metastases occur and how they affect quality of life. The goa…

This study is testing whether a special type of PET scan, which measures how the brain uses sugar, can help doctors better understand multiple sclerosis (MS). Researchers will compare brain scans from people with different types of MS and healthy volunteers. The goal is to see if…

This study looks at how different diets change the timing of hunger, eating, and energy use. Healthy adults aged 18-45 will eat provided meals and track their food intake. They will also have two short hospital stays for blood, urine, and saliva tests. The goal is to understand h…

This study tests a new, standardized way for pathologists to examine lung tissue removed during surgery for lung cancer. The goal is to find more lymph nodes that might contain cancer cells, which could lead to better staging and help more patients get the right follow-up treatme…

This study explores whether a smartphone app can help doctors monitor surgical wounds remotely. About 150 adults having certain surgeries will choose to use the app or be in a control group. App users take daily or weekly photos of their incision and answer questions; an AI progr…

This study tests whether a computer alert can help doctors identify patients with a genetic type of high cholesterol called Familial Hypercholesterolemia. About 450 adults at risk will be enrolled. The goal is to see if the alert increases diagnosis and helps lower cholesterol le…

This study looks at whether melatonin, a natural sleep hormone, can change how often the uterus contracts in full-term pregnant women. Researchers will give melatonin during the day (when levels are low) and use bright light at night (to lower natural melatonin) to see the effect…

This study looks at how healthy women aged 18-35 react to sleep loss depending on where they are in their menstrual cycle. Researchers will measure alertness, body temperature, and hormone levels. The goal is to understand if the menstrual cycle affects how the body handles lack …

This study looks at why some people improve their thinking skills after a brain injury while others don't. Researchers will have 30 adults with mild cognitive problems do intensive computer-based brain exercises. They will measure changes in thinking, brain activity, and blood ma…

This study tests whether using a lower amount of bicarbonate in dialysis fluid is safer for the heart than the standard higher amount. About 141 hospitalized adults on long-term dialysis will be randomly assigned to one of the two levels during their hospital stay. The main goal …

This study watches 80 people with advanced kidney disease who are waiting for a kidney transplant. Researchers will measure heart blood flow and function before and after the transplant to see if the new kidney helps the heart. The goal is to understand how kidney disease and inf…

This study tests whether a special ultrasound treatment can improve blood flow and heart function in people with cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers will compare 70 participants with and without the disease, measuring change…

This study watches 1,000 adults having surgery to see if things like worry about pain, sleep trouble, and anxiety change how well numbing medicine works. Researchers also track how much opioid painkiller people need and if long-term pain develops. No new treatment is tested—the g…

This early study is testing a small implantable device that sits inside a tumor and measures how different chemotherapy drugs work against ovarian, fallopian tube, and peritoneal cancers. About 20 people with advanced cancer will have the device placed and removed during standard…

This study uses a special PET scan to look at a brain chemical system (norepinephrine) in people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if damage to this system is linked to MS symptoms like fatigue and thinking problems. About 19 adults aged 18 t…

This study tests a computer tool that creates 3D models of broken shinbones to help surgeons plan where to place screws and plates. About 40 adults with lower leg fractures will have their CT scans used by the tool to simulate different repair options. After surgery, surgeons wil…

This study tests whether a smartphone app that tracks symptoms can help prevent complications after patients with multiple chronic conditions leave the hospital. About 1,300 adults will use the app to report how they feel, and doctors will be alerted if problems arise. The goal i…

This study tracks 150 adults having planned open-heart surgery to see how often atrial fibrillation (AF) occurs afterward. Participants wear a small EKG patch to record heart rhythms, and researchers will look for patterns and risk factors. The goal is to better understand AF's t…

This study uses a new type of PET scan to measure the density of synapses (connections between brain cells) in people with progressive multiple sclerosis (MS). Researchers will compare these measurements with those from people with relapsing-remitting MS and healthy volunteers. T…

This study looks at how HIV and TB medicines work together in children under 6 years old who have both infections. The goal is to find the right doses to make treatments safer and more effective. About 20 children will take part, and researchers will measure drug levels in their …

This study looks at whether a person's genetic makeup (specifically the CAV-1 gene) affects how well they respond to GLP-1 receptor agonist drugs (like Ozempic or Wegovy) for weight loss and heart health. Researchers will enroll 30 overweight or obese adults to measure changes in…

This study looks at whether a specific diet can prevent or reduce the negative health effects of working night shifts. Healthy adults aged 18-45 will stay in a research center twice, eat identical meals, and provide blood, urine, saliva, stool, and rectal swab samples. Researcher…

This early-phase study tests a small implantable device that delivers tiny amounts of different drugs directly into head and neck tumors. The goal is to see which drug works best for each person before full surgery. About 30 adults with certain head and neck cancers will take par…

This study involves 171 people with light chain amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers will use special PET and MRI scans to track these deposits and understand how they cause heart problems. The goal is not to treat the disease dir…

This study aims to find genetic factors that make some people develop severe COPD at a young age (under 53). Researchers will analyze DNA from 2,000 participants to understand why some smokers get the disease while others don't. The study does not test any treatment—it only obser…

This study follows 260 adults undergoing heart surgery to see how developing atrial fibrillation afterward affects their quality of life. Participants will fill out surveys about their physical and mental health. The goal is to better understand the impact of this common complica…

This study looks at whether teaching digital skills to Latino adults with type 2 diabetes during a hospital stay helps them use patient portals and telehealth after discharge. Participants get one-on-one training from a digital navigator, while others receive standard care. The g…

This study looks at whether a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) helps older adults with lung cancer get better support during their radiation treatment. The assessment checks things like physical function, nutrition, and mental …

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will attend 8 weekly sessions with a pain psychologist and be assigned to either cognitive behavioral therapy or fibromy…

This study looks at two ways to remove small lung nodules in people with lung cancer. One method uses special imaging during surgery (iVATS), while the other is the standard VATS technique. Researchers will measure how long each surgery takes, how long patients stay in the hospit…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study is testing whether a new machine that combines radiation therapy with real-time MRI imaging is safe and practical for treating several types of cancer, including stomach and breast cancer. About 70 adults will receive this treatment along with chemotherapy. The goal is…

This study follows 60 babies who are at high risk for cerebral visual impairment (CVI), a brain-based vision problem that often goes undiagnosed until later childhood. Researchers will use brain scans, vision tests, and developmental checkups to find early signs of CVI by age 2. …

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study is testing a safe, noninvasive technique called TMS (transcranial magnetic stimulation) to see if it can affect brain areas linked to hunger and fullness in people with Prader-Willi syndrome. Twenty participants will receive TMS and have brain scans before and after. T…

This study tests whether a powerful cholesterol-lowering drug (evolocumab) can improve blood flow in the small vessels of the heart in people with stable coronary artery disease. About 50 participants will receive the drug for 12 months and have heart scans before and after to me…