Brigham And Women's Hospital

This study aimed to test if a daily pill called deucravacitinib could help adults with palmoplantar pustulosis, a chronic skin disease that causes painful blisters on the palms and soles. Participants took the medication for 24 weeks while researchers checked if their skin sympto…

This study tested whether adding an extra step to a standard heart procedure works better for people with paroxysmal atrial fibrillation (episodes of irregular heartbeat). Researchers compared two approaches: the standard pulmonary vein isolation procedure alone versus that same …

This study tested whether weekly injections of a drug called inotersen could slow or stop the progression of a serious heart condition called TTR amyloid cardiomyopathy. The drug works by reducing the production of a problematic protein that builds up and damages the heart. Over …

This study tested if using a faster, bedside blood test (called ROTEM) could improve treatment for severe bleeding after childbirth (postpartum hemorrhage). The goal was to see if this test could help doctors give the right blood products sooner, potentially reducing the total am…

This study tested whether using real-time imaging during surgery could help doctors more accurately find and biopsy abnormal lymph nodes deep in the abdomen. The goal was to make these diagnostic surgeries safer, with less tissue damage and fewer complications. The trial was term…

This study tested whether shining a specific type of ultraviolet (UV) light inside the mouth could help treat painful sores and symptoms caused by chronic graft-versus-host disease (cGVHD). cGVHD is a common complication after a bone marrow or stem cell transplant where the donor…

This study tested if connecting people with rheumatoid arthritis (RA) in a 'buddy' support program could improve their daily function, medication use, and symptoms. It paired 65 adult RA patients to provide mutual understanding and social support. The goal was to see if this peer…

This small, early-stage study aimed to see if a daily dose of the drug tasimelteon could help people with REM Behavior Disorder (RBD). RBD causes people to physically act out their dreams, which can lead to injury. The study measured if the drug reduced these dream enactment even…

This study aimed to see if starting the multiple sclerosis (MS) medication ozanimod could reduce the severe fatigue many patients experience. Researchers observed 26 adults with MS for three months, using smartphone apps and activity trackers to measure fatigue, mood, and sleep. …

This study aimed to understand how changing levels of a natural hormone called allopregnanolone might contribute to depression in women during perimenopause. Researchers planned to give some participants a drug that increases this hormone to see how it affected their mood and bra…