Brigham And Women's Hospital

This study tested a special UV light (narrow-band UVB) shone inside the mouth to treat painful sores from chronic graft-versus-host disease (cGVHD), a complication after bone marrow transplant. Eleven participants received the light therapy to see if it could ease symptoms and be…

This study tested a drug called inotersen in 31 people with a rare condition where a protein builds up in the heart, causing damage. The drug is designed to lower the amount of that protein made by the liver. The goal was to see if it could slow or stop the heart disease, but the…

This study tested whether a rapid blood test called ROTEM could help doctors give the right blood products faster during severe bleeding after childbirth. The goal was to reduce the total amount of blood transfused and lower the need for intensive care. The study included 49 wome…

This study tested a daily pill called deucravacitinib for people with palmoplantar pustulosis, a chronic skin condition causing painful blisters on the palms and soles. Only 3 adults with moderate-to-severe disease were enrolled before the trial was stopped early. The goal was to…

This early pilot study tested whether a daily 20 mg dose of tasimelteon, a medication that mimics melatonin, could reduce dream-enacting behaviors in people with REM behavior disorder. Researchers planned to enroll 20 adults with a confirmed diagnosis and track symptoms using sle…

This study aimed to see if the drug ozanimod could reduce fatigue in people with multiple sclerosis (MS). Researchers planned to follow 26 adults with MS for three months, measuring fatigue with questionnaires and looking at brain MRI scans. The study was terminated early, so res…

This study tested whether using special imaging during surgery could help doctors more accurately and safely biopsy lymph nodes in the abdomen. It involved 11 adults with suspected lymphoma or swollen lymph nodes. The approach used real-time image guidance to target the biopsy, a…

This study aimed to see if pairing rheumatoid arthritis patients for one-on-one support could improve their daily function and medication habits. Researchers planned to enroll 65 adults with RA to measure changes in health and well-being. The study was terminated early, so result…

This study aimed to understand how a natural brain chemical called allopregnanolone influences depression in women going through perimenopause. Researchers planned to measure changes in mood and thinking patterns. However, the study was stopped early and only enrolled 2 participa…