Brigham And Women's Hospital

This study looks at how dupilumab helps people with aspirin-exacerbated respiratory disease (AERD) and nasal polyps. Seventeen adults with AERD, asthma, and nasal polyps received the drug to see if it reduces inflammation and improves smell. The goal is to understand how the drug…

This study looks at whether endoscopic sleeve gastroplasty (ESG), a procedure that makes the stomach smaller using a flexible tube through the mouth, can improve liver health in 20 adults with obesity and advanced NASH (a severe fatty liver disease with scarring). Researchers wil…

This study tests whether a magnetic bead tracking system, used together with a bone-anchored implant and a robotic ankle-foot prosthesis, can give people with below-knee amputation more natural control over their prosthetic limb. Up to 7 participants will receive the implants and…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at high risk of coming back after radiation alone. About 134 adults with brain tumors from cancers like melanoma, lung, breast, or …

This study tests whether electronic alerts in medical records help doctors prescribe stronger cholesterol-lowering medications for heart disease patients with high LDL. About 400 adults with heart disease and LDL over 80 mg/dL, already on a statin, will be randomly assigned to ha…

This study tests whether using MRI during brachytherapy (a type of internal radiation) can help doctors deliver treatment more accurately for gynecologic cancers. About 49 participants will receive standard brachytherapy, some with an MRI tracker to guide the procedure. The goal …

This early-phase study tests CP101, a capsule containing beneficial gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extende…

This study compares two diabetes medications, oral semaglutide and sitagliptin, in over 25,000 adults with type 2 diabetes and a specific type of heart failure (preserved ejection fraction). The goal is to see which drug better prevents serious heart events like hospitalizations …

This study aimed to see if a new drug, ION-682884, could slow or stop heart damage in people with TTR amyloidosis, a condition where abnormal protein builds up in the heart. Only patients who had already completed a 24-month study of a similar drug (inotersen) were eligible. The …

This study looks at whether replacing sugary drinks (like soda and energy drinks) with calorie-free alternatives (like diet drinks) helps adults with overweight or obesity lose weight. About 460 people will be assigned to one of four drink groups for six months. The main goal is …

This study tests whether taking 480 mg of magnesium glycinate daily for 12 weeks can lower blood pressure in adults with slightly high systolic blood pressure (125-159 mmHg). About 120 participants will take the supplement while maintaining their usual diet. The goal is to see if…

This study looks at two diabetes medications, tirzepatide and semaglutide, in 26,000 adults with type 2 diabetes and a type of heart failure called HFpEF. The goal is to see which drug better prevents hospitalizations for heart failure and death. Participants are already taking o…

This study tests different approaches to help patients with high cholesterol and heart disease get the right medicines to lower their cholesterol. About 300 adults at high risk or with established artery disease will take part. The goal is to see which method helps more patients …

This study tests whether a newer hormone drug (darolutamide) combined with radiation works as well as standard hormone therapy for intermediate-risk prostate cancer, but with fewer side effects on erections. About 234 men will take part. The goal is to control the cancer while he…

This study tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) can treat drug-susceptible tuberculosis faster than the standard 6-month regimen. About 94 adults with active TB in the lungs will be randomly assigned to either t…

This study looks at whether a treatment tailored to a specific gene (LSD1) can better control blood pressure and protect the kidneys in Black adults with hypertension. About 300 participants who carry a certain gene variant will follow a controlled diet and receive therapy for 4 …

This study looks at whether taking cocoa extract (a source of flavanols) or a daily multivitamin can help older adults prevent falls and maintain physical strength. Over 21,000 men aged 60+ and women aged 65+ are participating. The goal is to see if these supplements reduce injur…

This study tests a new way to treat pulmonary embolism (blood clots in the lungs) using a low dose of clot-busting medicine delivered through a thin tube guided by ultrasound. About 60 adults with moderate to severe clots will receive this treatment to see if it safely improves b…

This study compares two rapid treatments—electroconvulsive therapy (ECT) and ketamine—for adults with severe suicidal depression. Researchers will enroll 1,500 people aged 18 to 90 to see which approach works better and faster. The goal is to quickly reduce suicidal thoughts and …

This study tests a new finger-clasp device, called Lab Clasp, that measures lactate levels from skin fluid instead of blood. High lactate can signal sepsis, a life-threatening infection. The goal is to see if the device works as well as standard blood tests in 6 healthy adults, m…

This early-phase study tests a special PET scan (using 18F-fluciclovine) to see if it can more accurately show how far muscle-invasive bladder cancer has spread, compared to standard CT or MRI scans. Sixteen adults with bladder cancer scheduled for bladder removal surgery will ge…

This study looks at whether taking vitamin D and omega-3 (fish oil) supplements can prevent high blood pressure in healthy adults. Over 25,000 men and women without prior high blood pressure are taking daily supplements or placebos for several years. Researchers will measure chan…

This study tests if shining a special light inside or outside the mouth can prevent severe mouth sores in people getting a stem cell transplant. About 78 patients will be split into three groups to see which light method works best. They will receive daily light treatments and be…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the risk of developing atrial fibrillation (a type of irregular heartbeat) in healthy adults. Over 25,000 men and women without prior heart disease or stroke are taking part. Researchers are trac…

This study compares cranberry capsules to the antibiotic nitrofurantoin for preventing urinary tract infections (UTIs) after surgery for pelvic organ prolapse or urinary incontinence. About 142 women will be randomly assigned to take either cranberry or nitrofurantoin for 28 days…

This large study looked at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent cancer, heart disease, and stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if these common …

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which may damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo to see if …

This study tests a school-based program to help more children in South Africa get the HPV vaccine, which prevents several cancers. The program involves 600 fifth graders (ages 9-12) and their parents, working with local schools to make vaccination easier. The goal is to see if th…

This study looks at whether dupilumab, a drug already used for eczema, can help people with allergic contact dermatitis (a skin rash caused by contact with allergens). Seventeen adults with confirmed allergies will receive the drug and be monitored for changes in skin severity an…

This study looks at whether people who need rehab after a hospital stay can recover just as well at home as in a skilled nursing facility. About 300 adults will either receive care from a team of nurses and therapists in their own home or go to a traditional facility. The goal is…

This early-phase study tests whether low doses of inhaled carbon monoxide are safe for people with severe lung injury caused by sepsis or pneumonia. Only 5 adults will receive the gas through a breathing mask, and researchers will closely monitor side effects. The goal is to see …

This study tests a program called PATH-C, which uses positive psychology exercises (like gratitude and kindness) to help caregivers of stem cell transplant patients. About 80 adult caregivers will try the program and report on their well-being, quality of life, and physical activ…

This study tests whether a trauma-informed care plan (TICP) helps patients with complex health needs feel less stressed and more understood during medical visits. About 200 adults aged 18-60 who have frequent appointments will participate. Researchers will ask both patients and c…

This study tests a new smartphone app called Stellar Sleep that helps people with insomnia improve their sleep using cognitive behavioral therapy. The app is designed to be easy to use and can automatically track sleep data from wearable devices like Fitbits. Researchers want to …

This study aimed to see if a special nerve block (parasternal subpectoral plane block) could lower pain and the need for strong painkillers after open-heart surgery. It planned to compare the nerve block using a numbing medicine (bupivacaine) versus a placebo (salt water) in adul…

This study planned to test an experimental gene therapy called VM202 in people with painful diabetic neuropathy who were already taking opioid painkillers. The goal was to see if VM202 could safely reduce or replace the need for opioids. However, the trial was withdrawn before en…

This study looks at whether doing exercises at home works as well as going to a physical therapist for people with new Achilles tendon pain. About 56 adults with symptoms for at least 6 weeks will be randomly assigned to either a 12-week home program or formal therapy. They will …

This study tests if a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for two doses. Researchers will track migraine days and…

This study aimed to see if a sublingual film of dexmedetomidine (BXCL501) could quickly reduce agitation in adults with bipolar disorder or schizophrenia visiting the emergency department. It was a single-arm pilot study, but it was withdrawn before enrolling any participants. No…

This study looks back at 166 knee replacement patients who received a nerve block for pain. Researchers want to see how much pain they feel once the block wears off, and whether a special education session helps reduce that pain. The goal is to better understand and manage pain a…

This study looks at whether a special syringe called EpiFaith helps anesthesia residents learn to place labor epidurals more quickly. About 34 residents with little experience will each perform 20 epidural placements using either the standard syringe or the EpiFaith syringe. Rese…

This study tests whether a structured conversation between emergency doctors and seriously ill older adults (or their family members) can improve shared decision-making about intensive care. About 40 participants will be enrolled, and researchers will measure how long the convers…

This study follows 100 adults aged 35-70 with slightly high blood pressure to see how their body's production of the hormone aldosterone changes over time. Participants will have blood tests and blood pressure checks to track these changes. The goal is to learn more about how thi…

This study follows about 1,600 adults with rheumatoid arthritis over time to learn why some treatments work better than others and why some people have side effects. Researchers collect health data and samples to find biological markers that could predict how the disease will pro…

This study surveys parents of healthy newborns to understand their opinions about genome screening. Parents answer a short survey in the hospital and a longer one months later. The goal is to see if views change over time and if seeing hypothetical results affects their choices.

This study measures oxygen levels inside cervical cancer tumors during a type of radiation treatment called brachytherapy. Ten adults with cervical cancer will have tiny oxygen sensors placed in their tumors during the procedure. The goal is to learn how oxygen levels relate to t…

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can receive hospital-level care at home instead of in a hospital. The study will enroll about 41 people to see how many are eligible and willing to try this approac…

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with high blood pressure. Researchers will measure heart and artery health after low-salt and high-salt diets. About 120 adults with mild to moderate hypertension will participate. The goal i…

This study checks if a non-invasive skin sensor can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. If the sensor works well, it could reduce the need for repeated blood draws in these fra…

This study looks at how sleep problems like sleep apnea, insomnia, and poor sleep quality are linked to heart disease and diabetes in rural areas of the southern U.S. About 3,680 adults already in a larger health study will wear a sleep tracker and answer questionnaires. The goal…

This study looks at whether giving people with inflammatory arthritis extra help—like a list of community resources, a community specialist, or a nurse navigator—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed a…

This study tests a guide that helps health workers monitor young children's development in India and Guatemala. Researchers want to see if using this guide improves children's language, motor, and thinking skills. The study involves 624 children from birth to 24 months old.

This study aims to make transcranial magnetic stimulation (TMS) more precise by using MRI and EEG data. Fifty healthy adults will undergo brain scans and TMS sessions while performing a computer task. The goal is to see if targeting specific brain networks can improve reaction ti…

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with possible cancer symptoms will take part. Half of the communities get the pro…

This study looks at why some smokers develop chronic obstructive pulmonary disease (COPD) while others don't. Researchers are studying over 10,000 smokers and non-smokers to find genetic factors that may increase COPD risk. The goal is to better understand the disease, not to tes…

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 6 months in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study looks at whether taking vitamin D and omega-3 (fish oil) supplements can lower the risk of infections like colds, flu, and urinary tract infections in healthy adults. It involves over 25,000 participants from a larger heart and cancer study. The goal is to understand h…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing anemia in older adults. Researchers are following 2,000 people who are already part of a larger heart and cancer study. They will compare anemia rates between supplement …

This study looks at how vitamin K levels affect bone health in older adults who are already taking vitamin D supplements. Researchers will track fractures and bone density changes in over 25,000 men and women aged 50 and older. The goal is to understand the relationship between t…

This study looks at how eating habits affect weight loss after bariatric surgery. Researchers will compare people who lost a lot of weight with those who lost less, to see if diet plays a role. About 44 adults who had sleeve gastrectomy surgery will take part. The goal is to unde…

This study tests whether watching virtual reality (VR) videos can reduce weight-based bias in doctors. About 52 resident physicians will take bias tests before and after watching either a VR experience of patient encounters or a neutral video. The goal is to see if VR can help do…

This study follows over 1,300 pregnant women to understand what helps or hinders them in using birth control after giving birth. Researchers want to learn how knowledge, attitudes, and practical barriers affect family planning choices. The goal is to improve birth spacing and hel…

This study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use an ultrasound of the heart (echocardiography) to check resting cardiac output. The study includes 80 participants and is observ…

This study is testing a small, implantable device that can be placed inside a prostate tumor to see how it responds to different cancer drugs. The goal is to find out if this approach is safe and feasible in 35 men scheduled for prostate removal surgery. If successful, this metho…

This study tests a new digital platform that helps hospitals share patient information more reliably when a patient is transferred from one hospital to another. About 1,000 adults being moved to Brigham and Women's Hospital from three other hospitals will take part. The goal is t…

This study tests whether artificial intelligence (AI) can help doctors outline the prostate on ultrasound images more quickly and accurately during a type of radiation treatment called brachytherapy. About 36 adults with prostate cancer will take part. The goal is to see if AI-as…

This study looks at whether a smartphone app can help people with psoriatic arthritis manage their condition with fewer in-person doctor visits. About 278 adults who own a smartphone and take certain arthritis medications will use the app to report symptoms. Researchers will trac…

This study aims to find out how often a blood clotting disorder (thrombophilia) is the cause of repeated miscarriages. Researchers will track 1,000 women aged 18-40 who have had two or more pregnancy losses. The goal is to improve awareness and treatment so women don't have to su…

This study looks at 5000 adults who had a thyroid nodule found on a PET-CT scan. It compares those who had a follow-up thyroid ultrasound within 3 months to those who did not. The goal is to see if skipping the ultrasound leads to a higher risk of death over 7 years. The research…

This study looks at whether an educational discussion guide helps postpartum patients who had high blood pressure during pregnancy become more active in managing their health. About 150 new mothers will either receive the guide shortly after delivery or not, and their engagement …

This study looks at medical records from 770 people with advanced lung cancer to see if they can recreate the results of a famous clinical trial (KEYNOTE-042). The goal is not to treat patients directly, but to learn whether real-world data can be trusted for future research. Par…

This study follows over 5,700 people with coronary artery disease to find blood or ECG markers that can predict sudden cardiac death. The goal is to identify those at highest risk so they can get life-saving treatments like defibrillators. Participants have mild to moderate heart…

This study uses healthcare claims data from over 23,000 people with heart failure and type 2 diabetes to see if the drug empagliflozin works as well in everyday practice as it did in a major clinical trial. Researchers compare empagliflozin to another diabetes drug, sitagliptin, …

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, heart health markers, and overall life satisfaction in adults aged 65 to 80. About 97 participants who are already part of a larger study will eat pistachios regularly…

This study tests a tiny device, small enough to fit in a needle tip, that is implanted into bladder tumors. It releases very small amounts of different cancer drugs directly into the tumor to see which one works best. After about 3 days, the device and a bit of surrounding tissue…

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, and tirzepatide) against an older drug (sitagliptin). The goal is to see which one is best at preventing heart attacks, strokes, and death. Th…

This study is collecting information from over 2,600 young people (ages 12-30) who are at clinical high risk for psychosis, along with healthy volunteers. Researchers will use clinical assessments, cognitive tests, and biomarkers to build computer algorithms that can predict whet…

This study looks at medical records from over 800 people with advanced lung cancer to see if they can produce the same results as two earlier clinical trials. The goal is to learn when and how to use real-world data confidently for future research. Participants are not receiving …

This study aimed to see if a special heart MRI could detect hidden scar tissue in people with type 2 diabetes and predict future heart attacks or death. Researchers planned to follow participants for 5 years after a low-risk stress test. However, the study was withdrawn before en…

This study aimed to see if a computer program could predict how long patients would stay in a home hospital program. Researchers used data from past patients to train the program. The study was withdrawn before enrolling any participants, so no results are available.

This study looks at what causes POTS (a condition that makes your heart race when you stand up) and other nerve problems in people with Long COVID. Researchers will take one blood sample from 100 women and compare their immune systems to healthy people. The goal is to learn more …

This study looks at whether structured activities and environmental stimulation can improve thinking skills and brain flexibility in healthy adults aged 65 and older. Researchers will measure memory, attention, and problem-solving using computer tests. The goal is to understand h…

This study was designed to see if the drug alemtuzumab calms overactive immune cells in the brains of people with relapsing-remitting multiple sclerosis (RRMS). Researchers planned to use a special PET scan to track these cells over 18 months. The study was withdrawn before enrol…

This study looks at how eating salt changes the way our genes control blood pressure. Researchers will test 88 healthy adults aged 25-45 to see how their bodies respond to salt and a hormone called angiotensin II. The goal is to understand why some people are more sensitive to sa…

This study aimed to see if patients could follow a short-term protein-calorie restriction diet for 4 days before elective vascular surgery. Researchers planned to measure diet compliance and changes in blood markers related to stress and healing. However, the study was withdrawn …

This small study tests whether a special PET scan using [11C]acetate can detect early signs that the drug rapamycin is working in people with lymphangioleiomyomatosis (LAM), a rare lung disease. Seven adults with LAM and kidney growths will get one or two scans over 3-6 months. T…

This study looks at how changing what you eat can help people lose more weight after bariatric surgery. About 44 patients who had sleeve gastrectomy will take part. Researchers will measure hunger, calorie intake, and energy use to see if diet habits make a difference.

This study looks at health records from over 780,000 people with type 2 diabetes to compare four common second-line drugs: SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas. The goal is to see which drug is safest and most effective at preventing hear…

This early-stage study tests whether a daily pill called MIB-626 can enter the brain and affect aging-related pathways in people with mild Alzheimer's disease. Researchers will measure the drug and its byproducts in spinal fluid and use advanced brain scans to see if it boosts NA…

This study looks at health records from about 30,000 people with type 2 diabetes to see if results from a previous clinical trial (REWIND) can be reproduced using real-world data. Researchers compare two diabetes drugs to understand when real-world data can be trusted for medical…

This study aimed to see if a computer program could predict potassium levels in the blood using a simple heart monitor. Researchers planned to use data from patients treated at home. The study was withdrawn before any participants were enrolled, so no results are available.

This study tracks how well treatment is working in men with metastatic hormone-sensitive prostate cancer using special PET scans (PSMA-PET). Twenty participants will get a scan before starting standard therapy and another after 6 months. The goal is to see if these scans can help…

This study aimed to test a new system that adds tiny, edible silica particles to HIV pills. People living with HIV could use a smartphone app to scan the pills and automatically record when they take their medication. The goal was to see if the system is easy to use and accuratel…

This study tests different ways to invite adults with diabetes to meet with a pharmacist for medication support. About 590 participants will receive different letters and phone call schedules to see which approach works best. The goal is to find a simple, repeatable method that c…

This study looked at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. About 95 participants with mild memory concerns or at risk for cognitive de…

This study tests whether offering doctors one-on-one educational meetings about biosimilar medications leads them to prescribe more biosimilars instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab will be randomly offered either an in-person o…

This study planned to test a technique that uses heat to seal the needle track after a liver, kidney, or spleen biopsy, aiming to reduce bleeding in patients at high risk. It was withdrawn before enrolling any participants. The goal was to see how well patients and doctors tolera…

This study uses repeated MRI scans to track brain injury and growth in very premature babies (born before 33 weeks) while they are in the NICU. Researchers aim to understand when and why brain injuries happen and how the brain grows, so they can better identify babies at risk and…

This study looks at whether using a wrist activity tracker, plus coaching and financial rewards, can help people become more physically active after total knee replacement surgery. About 600 adults aged 40-85 who are scheduled for knee replacement will be randomly assigned to usu…