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Pistachio power: daily nut snack may boost brain and heart in seniors

NCT ID NCT06992544

Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study looks at whether adding pistachios to the daily diet for 6 months can improve memory, thinking speed, and other brain functions in adults aged 65 to 80. It also checks for changes in blood pressure and overall life satisfaction. About 97 participants who are already in a larger study will eat pistachios and complete smartphone-based brain games and surveys.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

97 people

The number who actually took part.

Started

May 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Active participant in COSMOS 2. Current age 65 to 80 years 3. Does not reside in the states of Arizona, Hawaii, or Wyoming (since Quest Diagnostics does not have locations in these states) Exclusion Criteria: 1. Tree nut allergy 2. Current intake of pistachios, peanuts, walnuts, or other nuts \>1 serving/week 3. Diagnosis of Alzheimer's disease or any other type of dementia 4. Diagnosis of cancer or CVD (MI, stroke, CABG, PTCA, or stent) within last 12 months 5. Changes in the dose or number of anti-hypertensive, lipid-lowering, or diabetic medications over the past 3 months prior to randomization 6. Does not own a smartphone or tablet 7. Unable or unwilling to abstain from pistachio intake for 6 months 8. Unable or unwilling to limit nut consumption to ≤1 serving/week for 6 months 9. Unable or unwilling to complete online questionnaires and cognitive assessments 10. Unable or unwilling to travel to a local Quest site for biospecimen collection 11. Unable or unwilling to provide consent to participate in the trial 12. Failure to complete the baseline Life Satisfaction Questionnaire 13. Failure to complete the baseline cognitive assessments 14. Failure to complete the baseline biospecimen collection

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Conditions

The condition(s) this trial relates to.

cognitive disorder Personal Satisfaction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiometabolic risk factors Cognition Life satisfaction

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.