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COPDGene: unlocking the genetic secrets of lung disease in smokers

NCT ID NCT00608764

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get COPD and others don't, which could lead to better ways to predict and prevent the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify people at high risk for COPD and guide future prevention or treatment strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results may take years to apply in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

10,718 people

The number who actually took part.

Started

Nov 2007

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Particpants with COPD will include outpatient clinic patients, patients in registries, previous study participants, and COPD Foundation volunteers. Participants without COPD will include spouses and friends of study participants with COPD and patients at primary care practices.

Ages

45 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled) * Self-designation of non-Hispanic white or African-American Exclusion Criteria: * Other lung diseases (except for asthma in participants with COPD) * Pregnant * Cancer (other than skin cancer) in the 5 years prior to study entry * Received antibiotics for a COPD exacerbation in the 1 month prior to study entry * First- or second-degree relative of a previously enrolled study participant

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Conditions

The condition(s) this trial relates to.

chronic bronchitis chronic obstructive pulmonary disease COPD, severe early onset pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchitis, chronic Emphysema Pulmonary disease, chronic obstructive

Contacts and locations

Locations

  • Ann Arbor VA Medical Center

    Ann Arbor, Michigan, 48105, United States

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • HealthPartners Research Foundation

    Minneapolis, Minnesota, 55440, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21224, United States

  • Los Angeles Biomedical Research Institute

    Torrance, California, 90502, United States

  • Minneapolis VA Medical Center

    Minneapolis, Minnesota, 55417, United States

  • Morehouse School of Medicine

    Atlanta, Georgia, 30310, United States

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • Reliant Medical Group

    Worcester, Massachusetts, 01608, United States

  • Temple University

    Philadelphia, Pennsylvania, 19140, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35249, United States

  • University of California at San Diego

    San Diego, California, 92103, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Texas Health Sciences Center at San Antonio

    San Antonio, Texas, 78229, United States

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