Heart health: do everyday supplements lower blood pressure?
NCT ID NCT01653678
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure or lower it in healthy adults. Over 25,000 people are taking part, with a smaller group having their blood pressure monitored around the clock. The goal is to see if these common supplements make a real difference for heart health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin D3 (cholecalciferol) and omega-3 fatty acids (fish oil)
- What this could lead to
- If it works, this could show that simple, affordable supplements help manage blood pressure and reduce the risk of hypertension.
- What could go wrong
- This is an observational analysis within a larger trial, not a dedicated treatment study. Results may be modest or not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
25,875 people
The number who actually took part.
- Started
-
Nov 2011
- Expected to finish
-
Jun 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
50 to 99 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Participants eligible and willing to participate in the main VITAL trial (NCT 01169259) who meet the following criteria are eligible to participate in the VITAL Hypertension ancillary study: all participants with no baseline history of hypertension and, for home visits in the subcohort of 1,000 participants, those living in selected cities throughout the U.S..
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
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