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Stomach surgery without incisions may reverse severe liver damage in obese patients

NCT ID NCT04820036

First seen Jan 08, 2026 · Last updated May 22, 2026 · Updated 25 times

Summary

This study looks at whether endoscopic sleeve gastroplasty (ESG), a procedure that makes the stomach smaller using a flexible tube through the mouth, can improve liver health in 20 adults with obesity and advanced NASH (a severe fatty liver disease with scarring). Researchers will measure changes in liver function, scarring, and pressure in the liver's blood vessels over 12 months. The goal is to see if weight loss from ESG can control or reverse liver damage, but participants may still need ongoing care.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

Conditions

Explore the condition pages connected to this study.