Brigham And Women's Hospital

This study is testing a counseling program designed to help men living with HIV in Uganda tell their sexual partners about their status. The program includes health education, communication skill-building, and creating a personal disclosure plan. Researchers want to see if this a…

This early-stage study is testing whether a daily supplement called MIB-626, which boosts a natural body chemical called NAD+, is safe for adults with Down syndrome. The goal is to see if raising NAD+ levels can help prevent or slow the progression of Alzheimer's disease, which i…

This study is testing two different ways of stitching the stomach to help people with obesity lose weight. Doctors will compare a simpler stitching pattern to a more complex one using a special device. The goal is to see which method leads to better weight loss and improved healt…

This study tests whether messages generated by an artificial intelligence (AI) tool can help heart doctors better follow established treatment guidelines for their patients. The AI will review a patient's medical records and send a brief, private message to their cardiologist bef…

This early-stage study is testing whether a drug called sparsentan can safely reduce severe protein leakage in the urine (proteinuria) for cancer patients. This kidney problem is a known side effect of certain powerful cancer drugs. The trial will involve about 20 adults who are …

This large study aims to compare two established strategies for managing moderate-to-severe asthma to see which better prevents dangerous flare-ups. It will enroll 4,100 adults who are at risk for asthma exacerbations and currently use inhaled medications. Researchers will direct…

This study is testing whether a supplement called NMN can help protect the heart and kidneys during and after coronary artery bypass graft (CABG) surgery. Researchers will give NMN or a placebo to 90 adults before and after their scheduled heart surgery to see if it reduces tissu…

This small pilot study is testing whether adding a short course of steroid medication to standard hospital care can help patients with severe heart failure shock. The condition causes poor blood flow and triggers harmful inflammation, even when using heart pumps. Researchers will…

This study aims to determine if using MRI brain scans to target a rapid depression treatment works better than using scalp measurements. Researchers will compare two methods of guiding accelerated transcranial magnetic stimulation (aTMS), a non-invasive brain stimulation treatmen…

This small, early-stage study is testing whether a common sweetener called xylitol can safely remove C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). Researchers will give different doses to small groups of participants to find the highest amoun…

This study tests whether personalized medicine trials can help older adults with heart failure find their highest tolerated beta-blocker dose. Fifty participants will either try a personalized approach where they test different doses while tracking how they feel, or receive stand…

This study is testing if a daily pill called colchicine can reduce inflammation and joint pain in people with calcium pyrophosphate deposition (CPPD) disease, a form of arthritis caused by calcium crystals in the joints. Researchers will compare colchicine to a placebo (sugar pil…

This study is testing whether providing hospital-level care at home is better than usual hospital care for people with moderate to severe dementia. It will involve 200 participants who have been hospitalized recently and live with or near a family caregiver. The main goal is to s…

This study aims to see if a medication called sacubitril/valsartan can reduce harmful scarring (fibrosis) inside the heart muscle of people with a specific type of heart failure. Researchers will compare it to another standard medication using heart MRI scans to measure changes i…

This study is testing if a common sweetener called xylitol, taken as a daily capsule, can safely remove C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). The goal is to prevent these patients from developing a serious C. difficile infection. Abou…

This small pilot study is testing if adding the drug dapagliflozin to standard treatment helps control kidney damage in people with active lupus nephritis. The trial will involve 33 adults who have recently been diagnosed with or had a flare-up of this serious kidney complication…

This study is testing personalized treatment plans for people with opioid addiction. Researchers will use computer algorithms to create customized treatment sequences that may reduce overdose risk and improve recovery. The study will involve 75 adults receiving care at behavioral…

This study tests if pharmacists can help patients and doctors use simpler, combined blood pressure pills. It aims to see if this approach helps patients better control their blood pressure. The trial will involve about 750 people with high blood pressure who are not yet on the co…

This study is testing whether focused ultrasound can safely reduce symptoms of obsessive-compulsive disorder (OCD) in people who haven't improved with standard treatments like therapy and medications. Researchers will use MRI-guided sound waves to target a specific brain area wit…

This study is testing whether therapy combined with the psychedelic compound psilocybin can help people with severe alcohol use disorder reduce their heavy drinking. Thirty-six adults who recently completed detox will receive therapy and be randomly assigned to get either a highe…

This small pilot study is testing whether tirzepatide, a medication currently used for diabetes and weight loss, can help people with severe cannabis addiction. Six participants will receive either the drug or a placebo injection in a random order to see if it reduces their cravi…

This study aims to find out which of two common antibiotics, fidaxomicin or vancomycin, is better at clearing C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). About 60 adult patients will be randomly assigned to take one of the antibiotics for 1…

This study is testing a smartphone app designed to help doctors monitor surgical wounds remotely. Patients who have had certain spinal or pain management surgeries can choose to use the app to take photos of their wound and answer questions about it. The app's AI and a healthcare…

This study is testing a new AI-powered tool called IntelliWell. It aims to find rare, usable sperm in testicular tissue samples from men with a severe form of infertility where no sperm is found in semen. If the AI successfully finds sperm that standard lab methods missed, those …

This study is testing whether bringing lung cancer screening directly to underserved Boston neighborhoods makes it easier for high-risk people to get checked. Researchers will also see if collecting information about participants' social needs and having them record a video messa…

This early-stage study is testing if a drug called ropeginterferon is safe and feasible to use in people who have a specific genetic change (JAK2 mutation) that puts them at high risk for developing blood cancers or blood clots, but who do not yet have the cancer. The main goals …

This study tests if a computer alert system can help doctors in community clinics prescribe blood-thinning medication to prevent strokes in high-risk patients with atrial fibrillation (AF). It will involve about 2,500 patients who are not currently on these medications. The goal …

This study tests a program combining food supplements with health coaching for pregnant women in rural Guatemala. It aims to prevent two related problems: mothers gaining too much weight while their babies don't grow properly. Researchers will follow 766 mother-child pairs for a …

This trial aims to see if a daily cholesterol-lowering pill (rosuvastatin) can safely prevent life-threatening blood clots in people with cancer. It will involve 4,000 patients who are at higher risk for clots but are not taking blood thinners. The study compares the statin to a …

This study is testing whether a 6-week Pilates exercise program, led by a physical therapist, can help adults with hypermobility conditions like Ehlers-Danlos Syndrome manage their pain and other symptoms. The main goal is to see if this approach is practical and acceptable to pa…

This study is testing whether a brief aromatherapy session can help reduce stress and anxiety in emergency department patients. Researchers want to see if smelling lavender for about 5 minutes is practical and acceptable in a busy hospital setting. The study will involve 60 emerg…

This study is testing whether a smartphone app that provides personalized music can help people with HIV manage their chronic pain. 60 participants will be randomly assigned to either use the music app daily for 3 months or receive educational materials about pain. The main goal …

This small pilot study aims to see if a package of chiropractic treatments is practical to study and might help adults with long-term neck pain. It will compare chiropractic care plus standard advice against standard advice alone in 40 people. The researchers will also check if c…

This study is testing whether a smartphone app can help adults with myeloproliferative neoplasms (MPNs), a type of chronic blood cancer, feel better and improve their daily lives. Researchers will compare 75 participants who either use the new wellness app or receive standard wri…

This study aims to understand if not getting enough sleep affects blood sugar control differently in healthy men and women. Researchers will have 32 participants spend time in a sleep lab, comparing their body's response to food after normal sleep and after several nights of rest…

This study tests whether sending patients information about their medications before a doctor's appointment helps improve prescribing decisions. It will involve 1,700 patients aged 65 and older at Brigham and Women's Hospital primary care clinics. Researchers will send some patie…

This study aims to understand how irregular, poor sleep harms brain function and thinking skills. Researchers will test if special, 'sleep-informed' lighting can help keep the body's internal clock on track and reduce brain stress during a week of controlled sleep deprivation. Th…

This study aims to develop and test a more precise method for targeting brain stimulation using transcranial magnetic stimulation (TMS). Healthy volunteers will have an MRI brain scan to create a personalized map, then receive TMS to specific brain areas while performing computer…

This study aims to understand if a non-invasive light therapy, called photobiomodulation, can influence the body's automatic stress response. Researchers will measure heart rate and other signals in 40 healthy adults before and after they complete a short, standardized stress tes…

This study aims to understand how a 12-week supervised exercise program benefits the hearts of older adults with high blood pressure. Researchers will enroll 42 sedentary participants and randomly assign them to either follow the exercise program or not. The main goal is to ident…

This study aims to understand if men and women's bodies respond differently to night work and disrupted sleep schedules. Researchers will measure changes in hunger, food cravings, and blood sugar control when participants' sleep is shifted. The findings could help design better w…

This study aims to understand how opioid pain medications affect breathing during sleep. Researchers will compare healthy volunteers with people who have obstructive sleep apnea. Participants will receive either morphine or a placebo during monitored sleep to measure breathing ch…