Brigham And Women's Hospital

This early-stage study tests if the drug ropeginterferon is safe for people with a JAK2 gene mutation who have high-risk features but no blood cancer yet. Twelve adults will receive injections every 4 weeks and be monitored for side effects and changes in their mutation levels. T…

This study tests whether dapagliflozin, a drug already used for diabetes and other kidney diseases, can help people with lupus nephritis—a serious kidney condition caused by lupus. About 33 adults with early active lupus nephritis will receive either dapagliflozin or a placebo al…

This early-stage trial tests whether xylitol, a common sugar substitute, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take xylitol by mouth, and researchers will check if the in…

This study looks at whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF. Scarring can make heart failure worse, so reducing it might improve outcomes. The study will use MRI scans to measure scarring be…

This study tests whether a pharmacist can help patients and their doctors switch to a single pill that combines multiple blood pressure medicines. The goal is to make it easier for people to take their medication and lower their blood pressure. About 720 adults with high blood pr…

This study compares two proven asthma treatment plans—MART and PARTICS—to see which works better at preventing severe asthma attacks. About 4,100 adults with moderate-to-severe asthma who are at risk for flare-ups will take part. Participants will be randomly assigned to one of t…

This study tests whether xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researc…

This study tests a non-invasive procedure called ExAblate MR-guided focused ultrasound for people with moderate to severe obsessive-compulsive disorder (OCD) who haven't gotten better with therapy or medication. The treatment uses sound waves to target a small area in the brain t…

This study tests whether providing acute hospital care at home can help people with moderate to severe dementia avoid hospital stays. Researchers will compare a group that receives home-based acute care with a group that gets usual hospital care. The goal is to see if home care l…

This study tests whether taking nicotinamide mononucleotide (NMN), a natural compound, before and after coronary bypass surgery can reduce damage to the heart and kidneys. About 90 adults at higher risk for complications will receive either NMN or a placebo. The goal is to see if…

This study tests whether combining a tongue-stimulating implant (HGNS) with an experimental drug combo (AtoOxy) can reduce breathing pauses during sleep more than either treatment alone. About 24 adults with obstructive sleep apnea who already have or will get the implant will tr…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder drink less. Thirty-six adults who recently completed detox will receive either a full or low dose of psilocybin during two th…

This early-stage study tests if sparsentan can reduce high levels of protein in the urine, a sign of kidney damage, in 20 cancer patients taking certain targeted therapies. The goal is to see if the drug can help protect kidney function without stopping cancer treatment. Particip…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days, and researchers w…

This study tests whether personalized treatment plans, guided by machine learning, can improve care for people with opioid use disorder. Researchers will enroll 75 adults receiving care at behavioral health centers to find the best sequence of treatments that lowers overdose risk…

This study aims to make breast cancer diagnosis faster in rural Rwanda by training non-radiologist clinicians to perform breast ultrasound. Currently, only specialists at city hospitals can do these scans, causing delays. The project will compare two support strategies—live remot…

This study tests whether taking rosuvastatin (a statin) daily for one year can safely prevent life-threatening blood clots in people with cancer. About 4,000 adults with newly diagnosed or relapsed cancer who are at high risk for clots will receive either the drug or a placebo. T…

This study tests the Korus smart mattress in 10 healthy adults to see if it can accurately detect body positions (like lying on the stomach) and automatically reposition the person to a safer side-lying position. The goal is to prevent sudden unexpected death in epilepsy (SUDEP) …

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study tests if a 7-day course of steroids can reduce dangerous inflammation in 30 adults with heart failure-related cardiogenic shock. Participants must have high inflammation levels and be on temporary heart pumps. The goal is to see if steroids safely help the heart and or…

This pilot study will test whether tirzepatide, a drug used for diabetes, can reduce cravings in people with severe cannabis use disorder. Six adults will receive either the drug or a placebo and then switch, so everyone gets both. The main goal is to see if the drug lowers cravi…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can help people with migraine have less disability from their headaches. About 160 adults with episodic migraine will either get usual…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty adults with HIV and ongoing pain will either use the app daily for 3 months or receive standard pain education. The goal is to see if the app is practical a…

This study tests if shining red or near-infrared light on the body (called photobiomodulation) can help healthy adults manage stress. Forty people will undergo a stressful test while researchers measure heart rate and other signs of nervous system activity. The goal is to see if …

This study explores whether Pilates-based exercises can reduce pain and improve daily life for adults with hypermobile Ehlers-Danlos syndrome or hypermobility spectrum disorder. Researchers will enroll 100 participants to test if the program is practical and helpful. The goal is …

This study tests whether colchicine, a drug used for gout, can lower inflammation and pain in people with CPPD disease. About 150 adults with joint inflammation will take either colchicine or a placebo daily for 6 months. Researchers will measure blood markers and pain scores to …

This study tests whether using a brain scan (MRI) to guide transcranial magnetic stimulation (TMS) works better than the standard scalp-measurement method for treating depression. About 160 adults with major depressive disorder will receive accelerated TMS (10 sessions daily for …

This study tests whether chiropractic care can help adults with chronic neck pain. Sixty people will either get chiropractic care plus usual treatment or usual treatment alone. Researchers will check if the study is practical and if pain, disability, and quality of life improve. …

This study compares two ways of placing stitches in the stomach to help people lose weight. Ten adults with obesity will get one of two patterns using a device called Endomina. The goal is to see which pattern leads to more weight loss and fewer side effects over a year.

This early-stage study tests whether a daily pill called MIB-626 is safe for adults with Down syndrome. The goal is to see if it can help prevent or slow down Alzheimer's disease, which is common in this group. Twenty-four participants will take either the pill or a placebo for 2…

This study tests whether a smartphone app called WELL-MPN can help adults with myeloproliferative neoplasms (MPNs) improve their diet, physical activity, symptoms, mood, and quality of life. About 75 participants will be randomly assigned to use the app or receive standard writte…

This study tests a drug called cenobamate to quickly stop frequent seizures or ongoing seizure emergencies (status epilepticus) in intensive care patients. Ten adults aged 18-70 who have many seizures per hour will receive the drug while being closely monitored. The main goals ar…

This study tests whether a personalized approach called N-of-1 trials can help older adults with heart failure find the beta-blocker dose that works best for them. Fifty participants aged 60 and older will be randomly assigned to either the personalized approach or enhanced usual…

This study looks at whether not getting enough sleep affects blood sugar control differently in healthy men and women. Researchers will have 32 participants stay in a lab for two separate 5-day periods, comparing normal sleep to restricted sleep. The goal is to understand sex dif…

This study looks at whether being male or female changes how the body handles working at night. Researchers will compare hunger, fullness, and blood sugar control in 36 healthy adults during simulated day and night shifts. The goal is to learn how to make shift schedules safer an…

This study tests a new program to help men living with HIV in Uganda share their status with partners. The program includes education, counseling, and role-playing. Researchers want to see if it helps more men disclose their HIV status compared to standard care. About 70 men will…

This study looks at how irregular sleep and certain types of lighting can throw off your internal body clock and affect your thinking and brain health. Researchers will monitor 40 healthy adults aged 18-40 to measure changes in sleep patterns, mental performance, and brain chemis…

This study looks at how opioids change breathing during sleep in healthy volunteers and people with obstructive sleep apnea. Researchers will give participants morphine or a placebo and measure their breathing. The goal is to understand the risks, not to test a new treatment.

This pilot study aims to see if a mobile lung cancer screening clinic can effectively reach high-risk people in Boston neighborhoods with limited healthcare access. About 125 adults aged 50-80 who smoke or quit within 15 years will get screened and share their social needs. Resea…

This study tests whether an AI tool can help doctors improve medication plans for adults with heart failure. The AI reviews patient records and sends suggestions to doctors before appointments. 500 patients will take part, and the study will check if more patients get the right m…

This study tests whether sending a brief, educational prompt to patients aged 65 and older before their primary care appointment can help them and their doctor decide together about starting or stopping statin medications. About 1700 participants will be randomly assigned to rece…

This study looks at how a 12-week cardiac rehabilitation exercise program affects the hearts of 42 adults with high blood pressure who don't currently exercise. Participants will have heart scans, fitness tests, and blood draws before and after the program. The goal is to find pr…