Brigham And Women's Hospital

This study looked at whether adults with acute illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. 160 rural patients were randomly assigned to receive hospital-level care at home or usual hospital care. The goal was to see if…

This study compared two blood pressure medicines—eplerenone and chlorthalidone—in 79 adults with obesity and high blood pressure or metabolic syndrome. The goal was to see if eplerenone could improve blood flow to the heart and reduce scarring, beyond just lowering blood pressure…

This study tested whether adding a drug called bezlotoxumab to a fecal microbiota transplant (FMT) could better prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). About 61 adults with at least two past C. diff infections took part. Th…

This study tested a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), as a possible pill-based treatment for obstructive sleep apnea (OSA). 117 adults with OSA who were not using CPAP took the medication for one month. The goal was to see if the drug combo cou…

This study tested a smartphone app and monitoring system to help people with rheumatoid arthritis track their symptoms between doctor visits. A trained manager watched the data and alerted healthcare providers when disease activity increased. The goal was to improve patient satis…

This study tested a drug called evolocumab (Repatha) to lower cholesterol in 81 kidney transplant recipients. High cholesterol is common after transplant and raises heart disease risk, but standard statin drugs can cause side effects in these patients. The goal was to see if evol…

This study tested whether personalized text messages, tailored by a computer algorithm, can help adults with type 2 diabetes take their daily pills more consistently. 28 participants received either custom or generic texts for 6 months. The goal was to improve medication adherenc…

This study looked at whether adding a low dose of lacosamide to levetiracetam is more effective than increasing the dose of levetiracetam alone for adults with epilepsy who still had seizures on a low dose of levetiracetam. Fifty-six adults participated, and the main goal was to …

This study tested a new approach to help people with substance use disorders take their daily HIV prevention pill (PrEP) consistently. Participants used a digital pill that sends a signal to a smartphone app when swallowed, allowing researchers to track adherence in real time. Th…

This study tested two medications, methylergonovine and carboprost, to see which works better for treating heavy bleeding after childbirth caused by the uterus not contracting properly. 100 women who had a cesarean delivery and still had bleeding after standard treatment took par…

This study tested a nasal spray called Protollin in 16 people aged 60-85 with early Alzheimer's disease. The main goal was to see if it is safe and tolerable, not to cure the disease. Participants received two doses one week apart and were monitored for side effects. The results …

This study tested whether community health workers and home blood pressure monitors could help adults in rural South Africa better control their blood pressure. 774 people with high blood pressure took part. The goal was to find the best way to manage this condition long-term.

This study tested ways to safely reduce unnecessary antibiotics in hospitalized patients with possible pneumonia who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to shorte…

This study tested a smart computer system that learns from each doctor's habits to suggest safer prescribing for older patients. About 1,249 patients aged 65+ and 70 primary care doctors took part. The goal was to see if personalized electronic health record reminders help doctor…

This study tested two ways to help doctors prescribe the best medications for heart failure patients using remote care. Over 500 adults with heart failure took part, and the goal was to see if these strategies increased the use of recommended drugs. The approach focused on optimi…

This study tested whether a low dose of the blood thinner apixaban (2.5 mg twice daily) can safely prevent blood clots from coming back in people who already had a clot triggered by a temporary risk factor (like surgery or injury) but still have ongoing risks (like obesity or lim…

This study tested whether sulfasalazine, a drug used for arthritis and inflammatory bowel disease (IBD), can help people with primary sclerosing cholangitis (PSC), a rare liver condition. About 32 adults with both PSC and IBD took either sulfasalazine or a placebo for several mon…

This study tested a new way to remove small lung nodules using a CT scanner during surgery. 25 patients with small, outer-edge lung tumors were treated. The goal was to see if the approach is safe and can successfully remove the nodules. The technique aims to make surgery more pr…

This small study tested whether taking naltrexone (a medication that reduces alcohol cravings) only when needed could help people who want to cut back or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took the pill before drinking or da…

This study looked at whether adding community health workers to regular care helps patients with type 2 diabetes and high blood pressure in rural Mexico. 168 adults took part. The goal was to see if their blood sugar and blood pressure improved and if they took their daily medici…

This study tested whether a special dye used in PET scans can detect abnormal protein clumps (amyloid) in the heart. About 30 people with known cardiac amyloidosis and 15 healthy volunteers received the dye and had heart imaging. The goal was to see if the scan can measure amyloi…

This study tested whether a short, in-class educational program could help children aged 7 to 12 living in areas with high Lyme disease rates learn how to protect themselves. The program taught kids about personal protective practices, early disease detection, and reducing tick h…

This study looked at whether taking daily vitamin D or fish oil supplements could help prevent depression in over 18,000 healthy adults. Participants took either supplements or a placebo for about five years. The results showed that neither vitamin D nor fish oil reduced the risk…

This large study tested whether taking daily cocoa extract (from the cocoa bean) and/or a standard multivitamin could lower the risk of heart disease and cancer in older adults. Over 21,000 men and women aged 60+ took the supplements for several years. Researchers tracked heart a…

This study looked at whether taking daily vitamin D3 (2000 IU) and omega-3 fish oil supplements can help prevent bone fractures in healthy adults. Over 25,000 men and women without prior cancer, heart disease, or stroke were followed. Researchers also checked if a person's vitami…

This study looked at whether giving pregnant women extra vitamin D could stop their children from developing asthma or wheezing in early childhood. About 876 pregnant women with a personal or family history of allergies or asthma took part. The main goal was to see if the childre…

This study looked at whether taking daily vitamin D or fish oil supplements can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.

This study tested whether taking a daily vitamin D3 supplement for 4 weeks could help people recently diagnosed with COVID-19 feel less sick and avoid needing doctor visits or hospital care. It also looked at whether the same supplement could protect their household members from …

This study tested a program that uses a computer algorithm to identify older adults at risk for falls and helps their doctors create personalized exercise plans. Over 11,000 people aged 65 and older from primary care clinics took part. The goal was to see if these tailored exerci…

This study looked at whether doing yoga online can help people with chronic pain. 94 adults with pain lasting more than 6 months took part in 8 weekly virtual yoga classes and did daily 30-minute yoga at home. The goal was to see if the program was practical and if it reduced pai…

This study tested whether a mindfulness program could help people with chronic low back pain reduce their opioid dose and feel less pain interference. 121 adults who were already planning to taper their opioids were randomly assigned to either a mindfulness group or a standard ed…

This study looked at three different ways to treat recent back or neck pain (less than 3 months) in over 3,000 adults. It compared usual care from a primary doctor with two other care models: one that coordinates and enhances decision-making, and another that uses individualized …

This study tested whether a sedative called dexmedetomidine, given during chest surgery, helps the lungs re-inflate and recover afterward. One hundred adults having lung surgery received either the drug or a placebo. The goal was to see if the drug improves lung aeration and redu…

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. 50 adults participated virtually. The study focused on whether people would join, compl…

This early-phase study tested whether palmitoylethanolamide (PEA), a natural molecule available as a supplement, could help people with opioid use disorder manage stress, craving, and pain. Twelve adults already on stable medication (buprenorphine or methadone) took PEA or a plac…

This study tested whether using a mindfulness app on a smartphone for 8 weeks could help people with fibromyalgia feel better. 54 adults with fibromyalgia either used the app or just tracked their symptoms. The goal was to see if the app was easy to use and if it helped with pain…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this approach improves aerobic capacity, physical function, metabolism, and bone health b…

This study tested a topical gel called MED3000 for men with erectile dysfunction that persisted 1.5 to 4 years after prostate cancer surgery. Twenty men who had nerve-sparing prostatectomy used the gel on demand. The goal was to see if it improved erectile function enough to make…

This study tested three doses of dextromethorphan (a cough suppressant) against a placebo to see if it could reduce central neuropathic pain in people with spinal cord injury. 26 adults with chronic pain took part in a crossover trial where each person received all doses in a ran…

This study tested two different ultrasound-guided nerve blocks to control pain in 20 women having mastectomy. The goal was to see if a newer, more side-lying block (proximal intercostal) is easier to perform and safer than the standard paravertebral block. Researchers measured ho…

This study tested a biofeedback device that uses muscle signals to help people relax and retrain muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had usual care alone. The go…

This study tested whether the sleep drug suvorexant could reduce insomnia severity and improve metabolic health in 31 midlife women (ages 40-65) who had both insomnia and early signs of metabolic syndrome. Participants took the medication for 4 weeks, and researchers measured cha…

This study tested whether a combination of two drugs, dextromethorphan (taken by mouth) and lidocaine (given through a vein), can reduce nerve pain in people with spinal cord injury. 26 adults with long-term pain took part in a carefully controlled trial where neither they nor th…

This study tested whether an active voiding trial (where the bladder is filled and then the patient tries to urinate) helps patients leave the hospital sooner after a same-day hysterectomy compared to a passive trial (waiting to urinate naturally). 130 women undergoing laparoscop…

This small study tested whether people with Parkinson's disease can safely use a brain-stimulation device called tDCS at home. Six participants, aged 40 to 70, used the device for 20 minutes each day for a week, with video call support. The main goal was to see if it was practica…

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. The main goal was to measure how well each treatment improved daily function and pain over 6 months. Results help guide patients and doctors in choosing the…

This study tested whether a short, 5-minute aromatherapy session using a lavender-scented tube could help reduce stress and anxiety in emergency department patients. 60 adults participated, with some receiving the real scent and others an unscented tube. The main goal was to see …

This early-phase study tested whether the drug acetazolamide can reduce the severity of breathing pauses that occur during REM sleep in people with obstructive sleep apnea (OSA). Eleven adults with REM-predominant OSA who were not using CPAP took part. Researchers measured change…

This study looked at whether giving testosterone to women over 60 with chronic back pain, low testosterone, and long-term opioid use could improve their pain and quality of life. 36 women received either testosterone or a placebo. The goal was to see if testosterone helps with pa…

This study looked at whether adults who have weight-loss surgery (sleeve gastrectomy) can recover safely at home instead of in the hospital. 28 patients were randomly assigned to either home care or hospital care. The goal was to see if home care is just as good for recovery, inc…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others and support each other in physical activity goals. Over one month, 33 participants used the app to see if it improved their confidence, social support, and activity …

This study tested whether taking a magnesium supplement (480 mg daily for 12 weeks) could lower blood pressure in adults with untreated high blood pressure. 59 participants were randomly assigned to receive either magnesium or a placebo. The goal was to see if magnesium could saf…

This study tested a mindfulness and exposure program in 13 adults with atrial fibrillation who also had high anxiety sensitivity. The goal was to see if the program could reduce heart-related anxiety, symptom burden, and AFib episodes. The approach combined mindfulness techniques…

This pilot study tested a non-drug device called Bioboosti to see if it could help people with insomnia sleep better. Twenty adults with insomnia used the device, and researchers measured changes in sleep quality and daytime sleepiness using standard questionnaires. The goal was …

This study tested whether doing simple positive psychology exercises—like writing a thank-you letter or recalling a past success—could help people recently diagnosed with multiple sclerosis (MS) feel more hopeful and improve their quality of life. Thirty adults with MS diagnosed …

This pilot study tested whether a smartphone-based cognitive behavioral therapy (CBT) program could help adults with both psoriasis and depression symptoms. Thirty participants used an 8-week coach-guided app. The study measured how many people completed the program, their satisf…

This study tested whether giving mannitol (a type of sugar solution) during dialysis can help prevent low blood pressure and reduce symptoms like dizziness or nausea. It involved 31 adults who were prone to low blood pressure during their regular dialysis sessions. Each person re…

This study tested a type of mindfulness training called Acceptance and Commitment Therapy (ACT) for women who have migraines 4 to 14 days per month. Researchers wanted to see if it's possible to run a larger study and whether ACT can reduce how often migraines happen and how much…

This study looked at whether a special type of genetic counseling, which uses charts and graphs, helps newly diagnosed breast cancer patients make more informed decisions about surgery. About 400 patients took part. The goal was to see if this method changes how patients understa…

This study looked at over 11,000 people with type 2 diabetes and a certain type of heart failure to see if information from insurance claims could give the same results as a traditional drug trial. The goal was to learn when real-world data can be trusted to answer medical questi…

This study followed 10 people with relapsing multiple sclerosis for 9 months to see how the drug ofatumumab affects microglia, the brain's immune cells. Researchers used special PET scans and blood tests to track changes. The goal was to understand how the drug works in the brain…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer talk about their care wishes while in the emergency department. Researchers worked with 141 patients to see if the program increased how often they discussed the…

This study looked at medical records from over 163,000 older adults with high blood pressure to see if one type of blood pressure medication (dihydropyridine calcium channel blockers) was linked to a lower risk of developing dementia compared to another (hydrochlorothiazide). Res…

This study analyzed health records from over 740,000 older adults with diabetes to see if certain diabetes medications, like semaglutide, are linked to a lower risk of developing dementia or Alzheimer's disease. Researchers compared people taking semaglutide to those on other dia…

This study looked at past patient records to see if a computer program could predict who would need to be readmitted to the hospital within 30 days of leaving. Researchers used data from 372 patients treated at home through a hospital program. The goal was to improve care, not to…

This study tested how changing the frequency of AI suggestions affects people's decisions in a medical imaging task, like deciding whether to recall a woman for further breast cancer screening. Twelve volunteers completed an online experiment where they reviewed images with AI as…

This study looked at how a new gel form of the antibiotic azithromycin is absorbed in the body compared to the standard pill. Eighteen healthy adults took the drug in different forms (oral gel, rectal gel, and pill) on separate days. The goal was to see if the gel versions work s…

This study looked at health records from nearly 4,000 women with advanced breast cancer to see if they could recreate the findings of an earlier clinical trial called MONARCH-3. The goal was not to test a new treatment, but to learn whether real-world data can be trusted to answe…

This study followed over 1,000 people in the Dominican Republic to learn how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested blood for antibodies, and asked about handwashing habits. The goal was to understand the virus better and find ways to reduce …

This study looked at how low blood sugar (hypoglycemia) affects the body's ability to control heart rate in 14 adults with well-controlled type 2 diabetes. Researchers measured changes in baroreflex sensitivity—a key heart rate regulation mechanism—before and after a controlled l…

This study looked at why some people feel a sharp increase in pain when a numbing injection (nerve block) wears off after surgery. Researchers gave 40 healthy adults a nerve block in one arm and measured their pain sensitivity as the numbness faded. The goal was to see if the ner…

This study tracked over 11,000 COVID-19 patients to find out how often they develop dangerous blood clots in arteries or veins. Researchers looked at risk factors, treatments, and outcomes like heart attack, stroke, or death. The goal was to better understand and prevent these co…

This study looked at whether a program called COPE helps Navajo people with diabetes and other chronic conditions. The program trains community health workers to support patients and coordinate with doctors. Researchers compared health measures like blood sugar and blood pressure…

This early-stage study gave hydroxocobalamin (a form of vitamin B12a) to 10 healthy adults to see if it causes any side effects. The goal was to gather safety information before testing the drug as a possible treatment for ulcerative colitis and other bowel conditions. Participan…

This study looked at whether taking daily vitamin D or fish oil supplements could reduce the risk of autoimmune diseases, lower inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease took part. Researchers measured inflamma…

This small study tested whether a 3D CT scan technique could measure changes in lung blood vessels after standard blood thinner treatment for pulmonary embolism (blood clots in the lungs). Ten adults with acute clots had a CT scan before and 48 hours after starting blood thinners…

This study looked at how healthy children aged 6 months to 5 years in Bahir Dar, Ethiopia, typically develop. Researchers used a portable MRI scanner to measure brain volume and gave age-appropriate tests of thinking, language, and school readiness. The goal was to understand nor…

This study looked at whether taking two blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of current and former smokers, both with and without COPD. Fifteen people participated in a crossover design where each person received both the acti…

This completed study looked at whether information from everyday healthcare claims can accurately predict the results of a large clinical trial (SURPASS-CVOT) that compared two diabetes drugs, tirzepatide and dulaglutide, for heart safety. Researchers analyzed records from over 4…

This study looked at how the sleep hormone melatonin and a specific gene variation (MTNR1B) work together to control blood sugar. Researchers tested 23 healthy adults in a controlled lab setting. The goal was to understand the connection, not to provide a treatment.

This study looked at 74 adults with active rheumatoid arthritis (RA) who had never taken biologic drugs. Researchers used heart scans to measure how well the heart's blood vessels work, aiming to understand if reducing inflammation lowers heart risk. The goal was to learn whether…

This study looked at how having low blood sugar (hypoglycemia) affects the body's automatic nervous system, which controls things like heart rate and blood pressure. Researchers tested 28 healthy adults to see if a drug called spironolactone could block these effects. The goal wa…

This study looked at whether giving financial rewards could encourage hospital employees to be more physically active. 292 participants who were not very active wore Fitbits to track their steps for 24 weeks. The goal was to see if incentives helped them increase moderate to vigo…

This study analyzes health records from over 158,000 people with type 2 diabetes to see if injectable semaglutide reduces major heart problems like heart attacks and strokes. Researchers are testing whether real-world data can reliably reproduce results from a previous clinical t…

This study looked at whether whole genome sequencing can be used to screen healthy babies for genetic risks. Researchers enrolled 500 infants and their families from three U.S. cities. Half of the babies had their DNA sequenced, and results were shared with parents and doctors. T…

This study tested whether getting emergency care at home works as well as going to the hospital emergency department. 229 adults who needed emergency care were randomly assigned to receive care at home or in the ER. The main goal was to see if home care led to fewer hospital visi…

This study tested a device that uses mild electrical pulses to help stroke survivors walk better. Ten adults who had a stroke participated, and researchers measured how their leg muscles responded with and without the device. The goal was to learn how to make this technology safe…

This study tested a new way to perform lower leg amputations that could help people use advanced prosthetic limbs more naturally. Researchers worked with 50 adults who needed an amputation due to injury, birth defects, or arthritis. The goal was to see if the new surgical method …

This study looked at health insurance records from over 58,000 people with type 2 diabetes and a type of heart failure (HFpEF). The goal was to see if a drug called semaglutide works as well in everyday patients as it did in a previous clinical trial. Researchers compared those t…

This study tested a program to improve heart failure care for Black and Latinx patients who are often treated on general medicine instead of cardiology. The program included standard treatment plans, cardiology checkups, and help with transportation. Researchers tracked whether m…

This study tested whether an electronic alert in the medical record system could prompt doctors to order a urine test that checks for early kidney damage in people with type 2 diabetes. About 400 adults who hadn't had this test in the past year took part. The goal was to see if t…

This study tested a digital pill system and a smartphone app to help HIV-negative men who have sex with men and substance use disorder take their daily HIV prevention pill (PrEP) consistently. Forty participants used a special pill that sends a signal when swallowed, and an app t…

This study looked at medical records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing Alzheimer's or other dementias. The goal was to find out if either drug could be repurposed to protect …

This study tested whether radiologists can quickly decide a breast cancer screening is normal by looking only at a 2D mammogram, without needing 3D images. Sixteen radiologists viewed cases for up to five seconds and rated their confidence. They also saw an AI opinion and said if…

This study looked at how to give healthy adults their genetic test results and what happens next. Researchers worked with 48 people from two long-running heart studies. They measured costs, how many people followed up with their doctor, and whether new health issues were found.

This study tested a new PET imaging method to measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers compared results from 18 participants with cardiac amyloidosis to those with other he…

This study involved 20 adults newly diagnosed with multiple myeloma who were starting treatment with daratumumab. Researchers collected blood and urine samples before and 30 days after starting therapy to measure specific biomarkers that might signal early kidney injury. The goal…

This study looked at medical records from over 28,000 people with type 2 diabetes and a specific type of heart failure (HFpEF) to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better reduces the risk of death or hospitalization for heart failure. T…

This study looked at 163 adults having ERCP, a procedure to examine the digestive tract. Doctors used two different types of endoscopes one after the other to see which one finds more important problems like ulcers or bleeding. The goal was to learn if a forward-viewing scope mis…

This study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). The goal was to understand why the combination works better than either drug alone. 27 adults with OSA took part, and researchers measured muscle ac…

This study looked at insurance claims from 70,000 people with type 2 diabetes and heart disease to compare two drugs, tirzepatide and dulaglutide, on their risk of heart attack, stroke, or death. The goal was to see if real-world data could mimic a large clinical trial. No new tr…

This study looked at whether real-world data can reliably compare two diabetes drugs—tirzepatide and sitagliptin—for preventing heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Researchers analyzed records from over 49,000 patients to see if this…

This study reviewed medical records of 800 multiple sclerosis patients to see if gender, race, or socioeconomic background influenced how quickly they started Ocrelizumab or how well it worked. Researchers looked at relapse rates and MRI changes over 12-24 months. The goal is to …

This study looked at how the body processes buprenorphine, a medication used to treat opioid use disorder, when given by mouth in different doses. Eighteen healthy adults who had used opioids in the past took part. The goal was to gather information on drug levels in the blood to…

This study looked at whether information from routine medical care (real-world data) can produce the same results as a traditional clinical trial for advanced breast cancer. Researchers analyzed data from over 6,000 patients in large health databases. The goal is to learn when re…

This pilot study looked at factors that might predict pain and function after total knee replacement surgery. Researchers tested a brief mindfulness-based therapy in a small group of patients and compared them to those receiving usual care. The goal was to gather initial data on …

This study looked at how two different diets affect people with primary sclerosing cholangitis (PSC), a rare liver disease. Twenty adults were randomly assigned to follow either a vegan/low-sulfur diet or the specific carbohydrate diet for 8 weeks. Researchers measured changes in…

This study looked at whether listening to music can lower cravings for opioids when people see drug-related images. Twenty-eight adults on stable medication for opioid use disorder took part. Researchers compared cravings before and after exposure to cues, with some participants …

This study looked at how changing sleep times each day affects the body's internal clock, learning, mood, and performance. Twenty-seven healthy adults stayed in a lab for 27 days and were assigned to either a regular or an irregular sleep schedule. Researchers measured changes in…

This study tested a short training for rheumatologists to help them focus on each patient's individual needs, aiming to reduce unconscious bias. Researchers looked at whether this training improved the quality of care for Black and lower-income patients with conditions like lupus…

This study looked at medical records of nearly 5,000 people with non-small cell lung cancer to see if they could get the same results as a famous clinical trial (FLAURA). The goal was not to test a new treatment, but to learn when and how real-world data can be trusted for resear…

This study looked at how a mild low blood sugar stress affects the brain and the body's automatic functions like heart rate and breathing. Researchers used brain scans to see changes in brain connections in 74 healthy adults. The goal was to understand how non-psychological stres…

This completed study looked at how oral opioids change pain sensitivity in 35 adults with chronic low back pain. Researchers measured pain responses using sensory tests to understand why some people respond differently to opioids. The goal is to help doctors tailor pain treatment…

This study looked back at data from over 2,300 people who had a stress cardiac MRI to see if certain heart function and structure findings could predict serious heart problems like heart attack or death. The goal was to understand how these MRI results relate to long-term outcome…

This study looked at data from 526 patients treated at home through a hospital-at-home program. Researchers used a computer algorithm to try to predict if a patient would get worse during their stay. The goal was to see if machine learning could help doctors spot problems earlier…

This study tested whether a standardized electronic note could improve communication and reduce medical errors when patients are transferred from one hospital to another. Over 1,600 adults admitted to general medicine, cardiology, oncology, or ICU services participated. Researche…

This study looked at how a stress hormone called ACTH affects the body's automatic nervous system, which controls things like heart rate and blood pressure. Researchers gave 23 healthy adults either the hormone or a placebo and measured changes in their nervous system. The goal w…

This study looked at medical records from over 155,000 older adults with high blood pressure to see if two common diuretics, amiloride and triamterene, affect the risk of developing dementia or Alzheimer's disease. Researchers analyzed data from Medicare claims between 2008 and 2…

This study looked at whether being exposed to artificial light at night, on top of not getting enough sleep, harms how the body handles sugar. 14 healthy adults spent over a month in a lab to test this. The goal was to understand how light and sleep loss together affect insulin a…

This study looked at health records from over 887,000 people with type 2 diabetes and overweight to compare two drugs—tirzepatide and semaglutide—for preventing heart attacks, strokes, or death. The goal was not to test a new treatment but to see if analyzing real-world data can …

This study looked at 10 people with multiple sclerosis to understand why they feel tired. Researchers used special brain scans to measure inflammation and chemical activity. They did not test any new treatments. The goal was to learn more about what causes MS-related fatigue.

This study tested a computer tool that forecasts a mother's blood pressure 1 to 3 minutes ahead during planned C-sections under spinal anesthesia. 20 women participated, and doctors used the forecasts alongside their usual care to manage blood pressure. The goal was to see how ac…

This study tested a simple idea: sending gentle reminders (nudges) to doctors and caregivers to help reduce or stop certain high-risk medications in people with dementia. Researchers worked with 250 patients aged 65 and older to see if this approach was practical and could be mea…

This study looked at whether taking daily vitamin D and fish oil supplements can improve bone density and structure in healthy adults. Researchers measured bone changes in 771 participants over time using scans and blood tests. The goal was to see if these common supplements help…

This study explored why sleep apnea can harm the heart and brain, even with standard treatment. Researchers used new ways to measure oxygen drops, heart rate changes, and sleep disruptions in 209 untreated adults. The goal was to better understand these risks, not to test a new t…

This study looked at how a molecule called IL-5 affects different cells in the nasal passages of people with chronic sinusitis and nasal polyps. Researchers analyzed tissue samples from 30 adults to understand why some people develop severe inflammation. The goal was to learn mor…

This study tested whether an on-screen alert in the electronic health record could remind doctors to screen for a rare but serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) in patients who previously had a blood clot in the lungs. About 400 adult…

This study looked at health records from over 800,000 older adults to see if certain blood pressure medicines (propranolol or carvedilol) might lower the risk of developing dementia or Alzheimer's compared to other similar drugs. The goal was to find new uses for existing medicat…

This study looked at 290 people who had sleeve gastrectomy surgery for obesity. Researchers wanted to see how what they ate during the first year after surgery affected their weight loss. The main goal was to measure changes in body mass index (BMI) one year after the operation.

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.

This study followed 168 women with Multiple Sclerosis who were pregnant or planning pregnancy. Researchers conducted phone interviews every three months during pregnancy and tracked babies' growth for up to three years after birth. The goal was to understand how MS and its treatm…

This study tested a care management program for 35 adults with lupus who were at high risk for emergency room visits or hospital stays. The program assigned a nurse manager to help patients get better outpatient care and stick with their appointments and medications. Researchers …