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Can a sugar solution stop blood pressure drops during dialysis?

NCT ID NCT04428372

Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving mannitol during hemodialysis can prevent blood pressure drops and reduce symptoms like dizziness. Thirty-one adults prone to low blood pressure during dialysis received either mannitol or a saline placebo. The goal was to see if mannitol improves comfort and stability during treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mannitol
What this could lead to
If it works, mannitol could become a simple option to help dialysis patients avoid low blood pressure and feel better during treatment.
What could go wrong
This is a small, early-phase study with only 31 participants, so results may not apply to everyone. Mannitol may not work better than saline, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

31 people

The number who actually took part.

Started

Apr 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Maintenance HD (\>90 days) * Age ≥18y * Thrice-weekly HD * IDH-prone (defined as nadir intra-dialytic SBP \<100 mmHg in ≥30% of sessions in the prior 4 weeks) * Hematocrit\>21% * Written informed consent Exclusion Criteria: * Acute myocardial infarction or stroke within one month * Pre-HD serum potassium \>6.5 mmol/L in last 4 weeks * Pregnancy * Institutionalized individuals * Life expectancy \<2 months * Planned renal transplant within 2 months * Active enrollment in another interventional trial * Known allergy to mannitol

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Conditions

The condition(s) this trial relates to.

dialysis disequilibrium syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodialysis complication Hemodynamic instability

Contacts and locations

Locations

  • Brigham and Women's

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.