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Scientists uncover how Yesterday's stress lingers in your body

NCT ID NCT02339506

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how stress changes the way your nervous system controls your heart rate. Researchers gave 23 healthy adults a hormone called cosyntropin or a placebo to see if it caused delayed changes in heart rate control. The goal was to understand the link between stress hormones and the body's stress response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Apr 2015

Finished

Nov 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Subjects must be currently healthy, BMI 18-32 kg/m2, and not be on any medications. This study will recruit men and women. Due to concerns about estrogen's effects on hormone levels and possible contributions of menstrual symptoms on pain sensing thresholds, we will schedule the inpatient studies to avoid the early follicular phase in normally cycling women. Subjects must have normal laboratory values for: 1. Complete blood count 2. Serum creatinine, sodium, potassium, glucose, liver enzymes 3. Urinalysis 4. Urine pregnancy test (if female) 5. Normal ECG Exclusion Criteria: We will exclude individuals with: * Systolic blood pressure \> 140 or \< 90 mm Hg * Diastolic blood pressure \> 90 mm Hg * Creatinine clearance ≤ 60 mL/min, as calculated by MDRD formula * Known DM, CHF, CAD, PVD, CVA, MI, asthma * Known or history of Cushing's disease or adrenal insufficiency * Known neurologic disease * Known psychiatric disease * Steroid use (oral or inhaled, local or systemic injections, within the past 6 months) * Significant concomitant medical illnesses * Current excessive alcohol (\>10oz ethanol/week) * Current use of recreational drugs * Current smokers * Current pregnancy * Chronic use of non-steroidal anti-inflammatory or narcotic medications * Evidence of ischemia or heart block on screening electrocardiogram (greater than type I-second degree heart block, left bundle branch block, or ST-T wave changes in 2 or more contiguous leads) * Subjects taking any prescription medications (other than oral birth control pills) or herbal medications will be excluded.

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Conditions

The condition(s) this trial relates to.

autonomic nervous system disorder baroreflex failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autonomic nervous system Baroreflex Stress, physiological

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.