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Dry january gets a boost: study tests On-Demand pill to curb drinking

NCT ID NCT07132177

Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether taking naltrexone only when needed can help people who want to reduce or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took a 50mg pill before drinking or daily as a precaution. The study checked if this approach was practical, safe, and acceptable, and measured changes in drinking habits and cravings. Results will guide future larger studies on low-cost ways to support moderate drinking goals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

19 people

The number who actually took part.

Started

Nov 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * English speaking adults aged 18 and above * Intending to participate in "Dry January" in January of 2026 by either completely stopping or moderating (reducing) their drinking * Available to travel to BWH CCI outpatient facilities for study visits Exclusion Criteria: * DSM-5 diagnosis of moderate or severe AUD * Seeking treatment for AUD * Currently receiving medications for treating AUD (naltrexone, acamprosate, disulfiram) * CIWA score \> 3 at the time of enrollment * Blood alcohol level (BAL) \> 0 at enrollment * Current DSM-5 diagnosis of any other SUD except for tobacco use disorder * History of any inpatient alcohol withdrawal (i.e. "detox") admission * History of severe withdrawal syndrome including withdrawal seizure or delirium tremens * Active psychosis, mania, suicidality or homicidally or any psychiatric condition that impair ability to provide informed consent * Liver function test greater than 3 times upper normal limit or severe renal impairment * History of hypersensitivity or allergy to naltrexone * Currently or anticipating requiring opioid analgesics for pain during the trial * Pregnant or breastfeeding * Anticipated to permanently leave the Boston area during the duration of the trial. * Anticipated to be enrolled in another clinical drug trial during participation of this trial * Any other reason or clinical condition that the investigators judge may interfere with study participation and/or be unsafe for a participant

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alcohol misuse

Contacts and locations

Locations

  • Brigham and Women's hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.