Massive study tests if daily pills can ward off diabetes
NCT ID NCT01633177
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether taking vitamin D or fish oil supplements every day can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin D3 (cholecalciferol) and omega-3 fatty acids (fish oil)
- What this could lead to
- If it works, this could point toward a simple, low-cost way to help prevent type 2 diabetes using daily supplements.
- What could go wrong
- This is a large, completed trial, but supplements may not reduce diabetes risk as hoped. Results may show no benefit or only a small effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
22,220 people
The number who actually took part.
- Started
-
Nov 2011
- Finished
-
May 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
50 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Participants in VITAL (NCT01169259) who have no history of diabetes mellitus at baseline are eligible to participate in this ancillary study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Division of Preventive Medicine, Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
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Other studies related to the condition(s) this trial covers.
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