Sleep apnea combo therapy shows promise in early trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Enrolment: * Ages 18 - 79 years * Diagnosed OSA * Implantation of a hypoglossal nerve stimulation device (HGNS, Inspire Medical) or scheduled for implantation (implantation required for randomization) * Willingness to withhold HGNS while testing therapies (up to 6 weeks with HGNS off \[with/without pharmacotherapy\] to assess benefits of HGNS therapy). Exclusion Criteria: * Any uncontrolled medical condition * Current use of the medications under investigation. * Issues relating to short-term withdrawal of HGNS therapy * Excluded: Occupational driving (truck drivers, fork-lift operation, taxi/uber drivers) * Excluded: History of traffic accidents attributable to sleepiness or fatigue (\<2 years). * Use of SNRIs/SSRIs or anticholinergic medications during the study. * Conditions likely to affect obstructive sleep apnea physiology: neuromuscular disease or other major neurological disorder, heart failure (also below), or any other unstable major medical condition. * Respiratory disorders other than sleep disordered breathing: chronic hypoventilation/hypoxemia (awake SaO2 \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions. * Other sleep disorders: narcolepsy, parasomnias. Insomnia * Contraindications for atomoxetine and oxybutynin, including: * hypersensitivity to atomoxetine or oxybutynin (angioedema or urticaria) * pheochromocytoma * use of monoamine oxidase inhibitors * diagnosed benign prostatic hypertrophy, urinary retention * suspected benign prostatic hypertrophy / urinary retention based on a positive answer to either of the following questions: 1. "During the last month, when urinating, have you had the sensation of not emptying your bladder completely more often than 1 out of 5 times?" 2. "During the last month, have you had a weak urinary stream more often than 1 out of 5 times? * known untreated narrow angle glaucoma * known bipolar disorder, mania, psychosis * known history of major depressive disorder (age\<24). * known history of attempted suicide or suicidal ideation within one year prior to screening * known clinically significant constipation, gastric retention * known pre-existing seizure disorders * known clinically-significant kidney disorders (eGFR\<60 ml/min/1.73m2) * known clinically-significant liver disorders * known clinically-significant cardiovascular conditions * moderate-to-severe hypertension (SBP\>160 mmHg or DBP\>100 mmHg measured at baseline; average of evening and morning measures) * known cardiomyopathy (LVEF\<50%) or heart failure * known advanced atherosclerosis * recent cerebrovascular events (within 2 years) * recent history of cardiac arrhythmias e.g., atrial fibrillation, QT prolongation (within 2 years) * other serious cardiac conditions that would raise the consequences of an increase in blood pressure or heart rate * myasthenia gravis * pregnancy/breast-feeding