Yale study to uncover how insulin resistance drives high triglycerides

NCT ID NCT05743868

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different types of insulin resistance (in fat or muscle) affect the liver's production of fats called triglycerides. Researchers will measure fat production after a meal, with and without exercise beforehand. The goal is to understand why some people have high triglycerides and how exercise might help. About 40 overweight adults with mild high triglycerides and signs of insulin resistance will participate.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to give informed consent * Overweight, defined as BMI 25-30 kg/m2 * Modest hypertriglyceridemia, defined as fasting plasma triglycerides 1.5-3.0mM * High risk of insulin resistance, defined as fasting plasma insulin \>64pM * Stable weight for at least 3mo prior to participation Exclusion Criteria: * Active or chronic liver disease, kidney disease, congestive heart failure, unstable angina, history of acute cardiovascular events within 6mo of screening, history of seizures or syncope, or an active infection requiring antimicrobial therapy; * Use of insulin, thiazolidinediones, SGLT2 inhibitors, or sulfonylureas; * Use of fibrates, omega 3 (fish oil), niacin, or PCSK9 antagonists; * Use of systemic glucocorticoids within 60d prior to participation; * Hematocrit \<35%; * Pregnancy of breastfeeding; * Active tobacco use, excessive alcohol intake (\>14U/wk), or history of drug abuse.

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Conditions

The condition(s) this trial relates to.

hypertriglyceridemia Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertriglyceridemia Insulin resistance

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Yale study to uncover how insulin resistance drives high triglycerides

What the study statuses mean