Can online therapy stop insulin resistance in HIV patients? new trial aims to find out
NCT ID NCT07226128
First seen Nov 10, 2025 · Last updated Jun 20, 2026 · Updated 30 times
Summary
This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy program to standard depression education in 150 participants over 12 months. The goal is to see if treating depression improves how the body uses insulin and reduces inflammation.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Indiana University Health
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
internet-based cognitive behavioral therapy (iCBT-D)
What this could lead to
If successful, this could show that treating depression with online therapy helps prevent insulin resistance and related health problems in people with HIV.
What could go wrong
This is a small, early-stage trial with only 150 participants, so results may not apply widely. The therapy may not improve insulin resistance as hoped.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.