HIV

This early-stage study tests whether a two-part HIV vaccine is safe and can trigger the immune system to produce special antibodies that may fight HIV. About 42 healthy adults without HIV will receive the vaccine and be monitored for side effects and immune responses over a year.…

This early-stage trial tests a new HIV vaccine called GRAdHIVNE1 in 120 healthy adults, both with and without HIV, in southern Africa. The main goal is to check if the vaccine is safe and to see how well it triggers the immune system. Participants will receive either the vaccine …

This early-stage study tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies against HIV. About 40 healthy adults without HIV will receive the vaccines to check for safety and measure immune responses. The goal is to see if this appr…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from Johns Hopkins HIV Clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and improve th…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations like a needle exchange site and community health centers. The goal is to help 400 participants stay in …

This study tests a new way to help people with HIV who have stopped taking their medication. Instead of a one-size-fits-all approach, participants can choose which services they receive and how. The goal is to see if this choice helps more people achieve an undetectable viral loa…

This study aims to reduce sexually transmitted infections like chlamydia and gonorrhea among Black youth aged 15–26 in New Orleans. Participants receive free testing for four STIs, and those who test positive get counseling and treatment options for themselves and their partners.…

This study tests new drug combinations for cryptococcal meningitis, a brain infection that is always fatal without treatment and still kills many people with HIV. The trial aims to find safer and more effective therapies by comparing several new antifungal regimens. About 2,000 a…

This study is testing a new injectable medicine called LP-98 in 30 adults with HIV who have never received HIV treatment. The goal is to see if the drug can safely lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and b…

This study tests two remote programs—peer support groups and strengths-based case management—for rural adults aged 50+ living with HIV in the Southern U.S. The goal is to improve viral suppression, medication adherence, and quality of life while reducing depression. About 352 par…

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women in Malawi who have HIV and depression. Researchers want to see if it reduces depressive symptoms and helps women stay in HIV care. About 400 wo…

This study tests whether metformin, a common diabetes drug, can lower inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, with or without HIV. Participants will take metformin or a placebo for 16 weeks and have their immune …

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, it helps participants cut down, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve overall health and re…

This study tests two types of support for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation, and the other gets extra help finding a job and money for health and career goals. The goal is to see which approach helps…

This study tests a program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program aims to reduce stigma and improve quality of life, mental health, and HIV management by focusing on the couple's relationship. Each partner…

This study in Uganda tests whether trained peer educators can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults will take part, with some clinics using the peer-led approach and others using standard care. The goal is to see if this method i…

This early-stage study tests whether lab-made antibodies that target HIV are safe and how the body processes them. About 83 healthy adults without HIV will receive one or three antibodies by vein or under the skin. The goal is to find the right dose and check for side effects, no…

This study tests whether combining a vaccine that attacks HIV with a long-acting antibody can help people with HIV control the virus without daily antiretroviral therapy (ART). The trial involves 48 adults with well-controlled HIV. Participants will receive the vaccine and antibo…

This study is for transgender women with HIV who are already on a stable three-drug regimen. It tests switching to a simpler two-drug combination (dolutegravir plus lamivudine) to see if it keeps the virus under control. About 50 participants will take the two-drug pill for 48 we…

This study tests if tirzepatide, a weekly injection, can help 12 overweight or obese adults with well-controlled HIV lose weight and reduce chronic inflammation. Participants will receive increasing doses over 12 weeks, and researchers will track body weight, body composition, li…

This study tests a support package for people with HIV in Malawi who often miss treatment when they move. It includes counseling, a hotline, and longer medication supplies. Researchers want to see if this approach is acceptable and practical for patients and healthcare workers. T…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV who still have low CD4 counts despite effective antiretroviral therapy. Researchers will randomly assign 120 participants to receive zinc supplements or continue their usual care. T…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure can stick with and enjoy. About 50 women aged 40 and older will take part. The goal is to see if the program is acceptable and helps with blood pres…

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them stop smoking tobacco cigarettes. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either us…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them focus better, take their HIV medication regularly, and stay in care after giving birth. About 100 economically vulnerable women will receive the cash or usual care. The goal is…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with home-based exercises, plus coaching and health education. Researchers want to see if this approach helps participant…

This study is for sexual and gender minority young people (ages 18-24) living with HIV in Rio de Janeiro, Brazil. It tests a program that combines counseling and technology to help them take their antiretroviral therapy (ART) regularly. The goal is to improve social support, conf…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage stigma and shame, set self-care goals, and build self-compassion. The goal …

This study tests a behavioral program for sexually active teens and young adults (ages 16-24) who use stimulants like meth, cocaine, or MDMA. The goal is to help them reduce stimulant use and risky sexual behaviors that can spread HIV. Participants will receive counseling and sup…

This study is for people living with HIV who also have a blood cancer that can be treated with a bone marrow transplant. Researchers want to see if a new mix of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease, a serious compl…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their depression and HIV viral levels improve within a year. Ten clinics in Cape Town, South …

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program to help women in Botswana who have both HIV and a serious mental illness, like schizophrenia or bipolar disorder. The program focuses on reducing stigma related to both conditions, especially after they leave a psychiatric hospital. Researchers will com…

This study looks at whether giving low-income Black men living with HIV a monthly payment of $500 for six months helps them get more HIV care and stick to their medication. Researchers in Arkansas want to see if this extra money can reduce the effects of poverty and racism on hea…

This study looks at whether peer navigation (support from other teens) and long-acting injectable HIV medication can help adolescents in South Africa keep the virus under control and stay in care. About 720 teens aged 12-19 who already take HIV pills will take part. The goal is t…

This study tests a 6-month behavioral health program for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants get counseling, peer support, and education tailored to their needs. Researchers will measure changes in depression, anxiety, substan…

This study tests whether using medical drones to deliver HIV medication to people living in remote fishing communities on the islands of Kalangala District, Uganda, can help more people achieve an undetectable viral load compared to standard delivery methods. About 1,086 adults a…

This study in Botswana tests whether a combination of three lab-made antibodies can keep HIV under control in children who started treatment early. About 41 kids aged 2 to 12 will receive the antibodies while pausing their regular HIV pills. The goal is to see if the antibodies a…

This study looks at whether starting HIV treatment quickly after diagnosis can reduce stigma and improve health in people who inject drugs. About 135 participants will be randomly assigned to either rapid-start or standard care. The goal is to lower HIV-related stigma and achieve…

This study looks at whether treating depression with an online therapy program can improve how the body uses insulin in people with HIV who are on HIV medication. About 150 adults with HIV and depression will either receive 9 weeks of internet-based cognitive behavioral therapy o…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past 2 years. The program teaches skills to manage stigma, improve communication, and connect with HIV care and safety resources. Researchers will check if t…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve an undetectable viral load. About 220 participants will receive either gabapentin or a placebo for 3 months, along with counseling. The goal is to see if the drug reduc…

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV reduce how much alcohol they drink. It will also check if it helps them smoke less and lowers their risk of heart disease. About 200 people will take the drug or a placebo for 3 months and pr…

This study adapts a peer-led program for pregnant and breastfeeding women who drink alcohol. Researchers will test whether trained mentor mothers can help 100 women reduce alcohol use and improve adherence to HIV prevention or treatment medications. The goal is to support healthi…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults with HIV who are patients at a North Carolina clin…

This study tests whether a simpler two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people starting HIV treatment while also being treated for tuberculosis. About 150 participants will be randomly assigned to one of three treatme…

This study tests a new way to help people living with HIV quit smoking. Researchers will compare a proactive, opt-out support program to standard care. About 231 adults with HIV who smoke will take part. The goal is to find the best method to help them stop smoking and improve th…

This early-phase study tests whether a person's own modified immune cells (CAR-T cells) can help control HIV without daily medication. Only 3 participants with well-controlled HIV will receive the treatment to check safety and see if the virus stays undetectable. The goal is a 'f…

This study tests if automated text messages can help people living with HIV quit smoking. Researchers will enroll 800 smokers in Cambodia and provide tailored text support. The goal is to see if this approach helps them stop smoking for good.

This study tests a program that combines peer support and text messages to help HIV-positive young men who have sex with men and transgender women (ages 15-29) in Nigeria stick with their HIV treatment and lower their virus levels. About 100 participants will receive the program …

This study tests a program to help people with HIV and substance use stick to their HIV medications and stay engaged in care. The program focuses on coping skills, managing substance use, and improving HIV care habits. About 50 adults with HIV who have used substances like cannab…

This study tests whether adding the HIV drug efavirenz to a person's regular antiretroviral therapy (ART) can kill cells that still harbor HIV, even when the virus is well-controlled. About 26 adults with HIV who have very low but detectable virus levels despite good medication a…

This study is testing whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and effective. The goal is to improve h…

This study aims to help people with HIV stay in care, especially during the first six months after starting or restarting treatment—a time when many drop out. Researchers are creating a toolkit that includes a risk assessment, a menu of support options, a treatment roadmap, and a…

This study looks at a Philadelphia program that provides housing to people with HIV who are homeless or at risk. Researchers want to see if having a stable home helps people stay on their HIV medication and keep the virus under control. About 200 people will be randomly chosen to…

This study looks at how well the HIV drug doravirine works in pregnant women. It involves 76 women who start HIV treatment in their second trimester. The goal is to find the right dose to keep the mother healthy and reduce risks to the baby.

This study tests a counseling program designed to help Black women living with HIV take their medication regularly and achieve viral suppression. Participants must be Black, cis-gender women aged 18 or older, with a history of trauma and recent unsuppressed viral load. The progra…

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for or living with HIV and also have substance use issues. The program provides support to start HIV prevention medicine (PrEP) or to lower the amount of virus in the body for those alread…

This study evaluates a new point-of-care test called MagIA H3S that can detect HIV, hepatitis B, hepatitis C, and syphilis from a single blood sample. Researchers will test about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab test…

This study tests a program called JUNTOS, where HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network helps more people get the care they need. About 245 participants and counselors will take p…

This study tests whether a combination of three lab-made antibodies, given through an IV, is safe and can help prevent HIV in healthy adults. Researchers will enroll 200 participants without HIV and follow them for 18 months. The goal is to see if these antibodies can neutralize …

This study tests a data dashboard that helps clinics in Alabama track and improve access to PrEP, a daily pill that prevents HIV. Researchers will work with 7 clinics to see if the dashboard helps more Black patients get PrEP and reduces racial gaps in prevention. The study invol…

This study tests a program called Shamba Maisha that provides farming tools and training to households in Kenya. The goal is to see if reducing food insecurity and poverty can lower the risk of sexually transmitted infections (STIs) and HIV in 800 teenage girls aged 15-19. Partic…

This study tests a program where people who use drugs give HIV self-test kits and service info to their friends. The goal is to increase HIV testing and connect more people to prevention (PrEP) or care. About 210 participants in California will help see if this peer-based approac…

This study looks at people with HIV between 65 and 74 years old to find those at risk for frailty—a condition that makes older adults weak and more likely to get sick or be hospitalized. Researchers will use a simple screening test and then offer a special check-up and care plan …

This study looks at a new way to help people in the Dallas County Jail get access to PrEP, a daily pill that prevents HIV. A patient navigator will meet with interested inmates to discuss HIV risk, offer testing, and connect them with PrEP providers after they are released. The g…

This study aims to see if a long-acting injectable HIV prevention drug (cabotegravir) works well for adults who inject drugs. 100 participants will receive the shot along with support services. The main goal is to see how many people stick with the treatment for 7 months.

This study aims to find low-cost, easy-to-use methods to encourage people at higher risk for HIV to get retested regularly. Researchers will test several behavioral nudges, like phone messages or reminders, in 40,000 adults in Kenya and Uganda. The goal is to see which approaches…

This study tests whether a peer-led community program can help Black men in Prince George's County, Maryland start taking PrEP, a daily pill that prevents HIV. Participants attend events focused on reducing HIV stigma and building social support. Researchers will compare how many…

This study looks at whether long-acting injectable HIV prevention drugs are worth the cost and can reduce HIV infections among Thai men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences and use computer models to compa…

This study tests a digital health program for women involved in the criminal justice system who have opioid use disorder. The goal is to help them start and stick with PrEP (a daily pill that prevents HIV) and medication for opioid use. Researchers will compare the eHealth tool t…

This study tests two approaches to help men who have sex with men and use methamphetamine get HIV prevention (PrEP) or treatment (ART) medication. About 400 men will be randomly assigned to receive either contingency management (rewards for filling prescriptions) alone or combine…

This study tests a program called STEP-UP that brings HIV prevention medication (PrEP) to people through trusted community organizations using telehealth. Researchers want to see if this approach makes it easier for people to get PrEP compared to the usual telehealth method. Abou…

This study tests an updated relationship education and HIV prevention program for gay, bisexual, queer men, and transgender/non-binary people who partner with cisgender men. About 5,000 participants will be randomly assigned to either the program or no program, and will be follow…

This study follows 5,000 HIV-negative adults in Italy who are taking pre-exposure prophylaxis (PrEP) to prevent HIV. Researchers will track how well PrEP works in everyday life, monitor side effects, and understand why some people stop taking it. The goal is to improve HIV preven…

This study tests whether text messages can encourage teens (ages 13-19) who have had sex to get tested for HIV. Participants are randomly assigned to receive either helpful texts or general health information. The main goal is to see if more teens get tested and share proof of th…

This study tests whether adding testing for common sexually transmitted infections (STIs) to standard risk screening helps more young women in Uganda start and stay on PrEP, a daily pill that prevents HIV. About 5,560 women aged 15-39 will be randomly assigned to either standard …

This study tests a new way to help Latinx men at risk for HIV start and stick with PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 ci…

This study tests two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV. Participants must be 25-65, have HIV, chronic pain, and in…

This study compares two medications, pramipexole and escitalopram, to see which works better for treating major depression in people with HIV. About 186 participants will take one of the drugs for several weeks, and researchers will track mood changes and side effects. The goal i…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study tests whether a type of magnetic brain stimulation called theta burst stimulation can reduce cravings for methamphetamine in people living with HIV. Thirty adults will receive the treatment and have their cravings and brain activity measured. The goal is to see if this…

This study tests whether group counseling and peer support can help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain feel less stigma about their health. About 195 adults will join counseling sessions and report how stigma affects their li…

This study tests whether a natural hormone called pregnenolone can improve depression and brain function in people living with HIV. About 120 adults with HIV and depression will take either pregnenolone or a placebo pill for several weeks, while continuing their usual antidepress…

This study tests a program called Friendship Bench + Safety Planning to see if it can reduce suicidal thoughts and behaviors in teenagers living with HIV. About 60 teens aged 13-19 in Lilongwe, Malawi will either get this program or standard care. The goal is to see if the progra…

This study is testing whether an AI-powered conversational agent can deliver a proven therapy (Dialectical Behavior Therapy) to help older adults with HIV manage suicidal thoughts and emotions. About 50 people aged 50 and older who are at risk for suicide will try the program. Th…

This study tests whether doing tai chi and qigong online can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will take either a 12-week tai chi class or a health education class, both via Zoom. Researchers will compare the groups to see if tai chi im…

This study follows 600 adults with known or suspected HIV in the Washington, D.C., area to better understand the infection and related conditions. Participants visit the clinic every 3-4 months for check-ups and blood tests. The study does not offer experimental treatments but he…

This 20-year study will collect information from up to 300,000 people visiting HIV and sexual health clinics in Thailand. Researchers aim to understand behaviors, social factors, and health needs to improve services. Participants answer surveys and may join group discussions, but…

This study looks at how fat stored around the heart and liver (ectopic fat) differs between people with HIV and those without. Researchers will use MRI scans to measure this fat and see if it explains why people with HIV have twice the risk of heart attacks. The goal is to gather…

This study looks at how to improve needle exchange programs in Canadian federal prisons so that more people who inject drugs use them. Researchers will work in nine prisons, including five women's prisons, to find what helps or hinders program use and put strategies in place to i…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services, especially for adolescent girls and young women. About 40 clinics will either use SAIA or continue their usual procedures. Researchers want…

This study reviews medical records from up to 1 million people in Malawi to understand how HIV treatment services are provided. Researchers want to see which care models work best, how many patients use them, and what they cost. No new treatments are tested—the goal is to gather …

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and viruses change over time. Participants join when diagnosed or starting standard antiviral treatments and are monitored for years. The goal is to understand the disease better,…

This study follows up to 19,000 people with HIV or at high risk for HIV in Washington, DC, to track their health outcomes and quality of care over many years. Researchers will measure how well HIV is controlled (viral suppression) and how quickly preventive services work. The goa…

This study collects large amounts of white blood cells from people with HIV using a process called leukapheresis. Researchers want to understand why the virus can stay hidden even with treatment and how inflammation affects the body. About 100 HIV-positive adults will take part, …

This study looks at whether menopause and HIV together raise the risk of heart disease in women. Researchers will examine inflammation and body changes using MRI scans and blood tests. The goal is to understand why heart risks increase in menopausal women with HIV. About 90 women…

This study looks at how two cannabis compounds, CBD and THC, affect inflammation and brain health in people with HIV. About 90 participants will take both compounds in a random order over 6 weeks. Researchers will measure blood markers and brain changes to better understand how c…

This study follows 30,000 HIV patients in 15 French clinics to see how well current treatments work over time. Researchers will track viral levels, treatment changes, and related infections like hepatitis C. The goal is to improve care, not to test a new drug or cure.

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. The goal is to see which methods work best to get more women screened and treated, ultimately improving their health and life …

This study tests whether having traditional healers offer HIV counseling and testing can help more people in rural South Africa learn their HIV status. Over 230,000 adults will be invited to test during healer visits. The goal is to see if this approach increases testing and conn…

This study aims to identify frailty in people aged 50 and older living with HIV. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging. The study involves 100 participants from a specialty clinic and does not test a…

This study looks at how medical care for HIV affects the quality of life of pregnant women and new mothers. About 100 women in Paris will fill out surveys during pregnancy and one year after giving birth. The goal is to learn what helps or hurts their well-being so hospitals can …

This study aims to understand what happens to HIV when people stop their daily medication for a short time. Researchers will use scans and tissue samples to measure virus levels in the blood and lymph nodes. About 50 adults with HIV who are on stable treatment will take part. The…

This study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants exposed to HIV. Ten caregivers in Saskatchewan will try PDHM as a supplement to breastfeeding or formula for 4 weeks. Researchers will track how often PDHM is used and ask careg…

This study looks at whether giving out special syringes that waste less medicine can help people who inject drugs stay safer from HIV and hepatitis. About 2,400 participants in nine countries will answer surveys and get tested. The goal is to learn what works best for distributin…

This study is testing simple decision-making guides to help doctors at district hospitals and health centers in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children. Over 30,000 sick children under 15 will take part, including those with HIV or severe mal…

This study looks at lymph node tissue from people with HIV to learn how the virus stays in the body even when medicines are working. Researchers will remove small lymph nodes from the groin area and measure how much HIV is there and how damaged the tissue is. The goal is to bette…

This study follows 380 children in Uganda for 2 years to see how malaria and HIV treatments affect each other. Half the children have HIV and half do not. Researchers will measure changes in body weight, drug levels, and malaria recurrence to improve treatment guidelines.

This study aims to find out if people with tuberculosis (TB) who have no symptoms can pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track how TB spreads. The goal is to better understa…

This study looks at whether a two-day employment program helps young Black sexual minority men stay engaged in HIV care. About 132 participants will attend the program and complete surveys over 13 months. Researchers want to see if the program is acceptable and feasible, and if i…

This study looks at how the immune system works in people with HIV who start treatment early. Researchers will collect white blood cells through a process called leukapheresis before and during therapy. The goal is to learn more about immune function, not to provide a new treatme…

This study looks at 320 people with HIV to create tools that can predict who will develop fatty liver disease or liver scarring. Researchers will track changes in liver health over time using ultrasound and a special scan called Fibroscan. The goal is to catch liver problems earl…

This study looks at how alcohol, cannabis, and certain medications impact falls and brain function in people with HIV. Researchers will enroll 100 participants from VA clinics to test a pharmacist-led intervention and gather feedback. The goal is to understand these risks and imp…

This study looks at how a damaged vagus nerve might cause gut issues and inflammation in people with HIV. Researchers will test a drug called pyridostigmine and vagus nerve stimulation as possible treatments. About 207 adults with well-controlled HIV will participate over 5 years…

This study collects blood, bone marrow, tumor, and tissue samples from adults with HIV, KSHV, or certain cancers. The goal is to gather samples for future research, not to provide treatment. Up to 999 participants will donate samples over time to help scientists learn more about …

This study collects white blood cells and plasma from 400 adults with HIV, including a rare group called long-term non-progressors who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand why some people's immune system…

This study tests whether a specially designed play can change how communities view young women who take PrEP (pills that prevent HIV). About 160 young women and community members in Kenya will watch the play and share their reactions. The goal is to see if storytelling can reduce…

This study looks at how long-term marijuana use affects brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure changes in brain health. The goal is to understand the effects, not to test a new treatment. About 220…

This study collects blood samples from people with and without HIV to help researchers study the virus. No treatment or medication is given. Up to 2,000 adults with good vein access can join. The goal is to provide samples for future scientific studies.

This study tests a combination program to improve HIV testing, get people into care quickly, and help them achieve viral suppression. Researchers will work with health departments in coastal Alabama to use data to target testing, connect people to care at diagnosis, and start tre…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves over time. Researchers will track whether tumors go away, come back, or spread, and how the immune system responds. Participants continue their usual KS treatment and underg…

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it's so hard to eliminate. The study involves up to 400 adults with and without HIV, who will…

This study follows 100 HIV patients who were treated early and then paused their medication as part of a remission research study. The goal is to monitor their health and see how the virus behaves after stopping treatment. Participants will have regular check-ups for up to 144 we…

This study is creating a long-term registry of people with HIV who undergo an upper endoscopy (a camera test to look at the stomach and esophagus). Researchers will collect information on patient characteristics and what the endoscopy finds. The goal is to better understand diges…

This study looks at whether getting legal help can improve HIV care for people who have been in jail. Researchers will work with 100 adults living with HIV who have a detectable viral load and a history of incarceration. They will also train healthcare providers on how to connect…

This study looks at whether older adults (60+) with HIV have more trouble exercising due to how their leg muscles use energy. Researchers will compare people with and without HIV using MRI scans and walking tests. The goal is to understand the link between HIV, muscle metabolism,…

This study tests three approaches to help older adults with HIV become more physically active: coaching, cognitive behavioral therapy for barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit to track steps. The…

This study looks at medical records from millions of people with HIV in South Africa to understand how different ways of delivering HIV care are working. Researchers want to see how many people are using these models, how well they control the virus, and what the costs are. No ne…

This study looks at two different ways to screen for cervical cancer in women with HIV. One way is to have women go to a central clinic for testing. The other way uses a mobile team that brings the test to where women usually get care. The goal is to see which method helps more w…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…

This study collects blood plasma and white blood cells from healthy volunteers, HIV patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH s…

This study looks at medical records from over a million people in Zambia to see how different ways of delivering HIV care are working. The goal is to understand which models help more patients stay on treatment and achieve viral suppression. No new treatments are being tested; in…

This study tests whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across ten European countries will be included. The teams will review medical records, remind doctors to offer HIV …

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers, then develop and test strategies to overcome them with a…

This study follows 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to understand why the parasite persists and causes repeat infections. They will analyze host and pathogen factors to improve treatment monitoring.…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood and other biological samples from up to 2,419 adults, both with and without HIV. Researchers will compare these samples to better understand the virus and related immune de…

This study works with five HIV clinics in the southern and eastern U.S. to create programs that reduce stigma against people living with HIV. Clinic staff and patients will take surveys every six months for two years to see if the programs help improve well-being and access to ca…

This study looks at whether doing cervical cancer screening and treatment in a single visit works better than multiple visits for women with HIV in Cameroon. About 1,422 women will take part to see if a one-visit approach reduces dropouts and is acceptable to patients and staff. …

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…