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Common diabetes drug tested to calm immune system in drug users

NCT ID NCT06829238

First seen Apr 30, 2026 · Last updated Jun 13, 2026 · Updated 5 times

Summary

This study tests whether metformin, a common diabetes drug, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, with or without HIV. Participants will take metformin or a placebo for 16 weeks and have their immune systems measured. The goal is to see if metformin can help restore immune balance and improve responses to vaccines.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

HIV infectious disease immune system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.