University Of Alabama At Birmingham

This study tests whether two different pneumonia vaccines can create antibodies that kill newly discovered types of pneumococcal bacteria. Researchers will give each vaccine to healthy adults and measure how well the antibodies fight the bacteria. The goal is to see if current va…

This study tests whether adding a growth factor (rhPDGF) to a standard bone graft helps rebuild the jawbone better than using saline alone. About 44 adults who need dental implants but have too little bone will receive one of the two treatments. The main goal is to measure how mu…

This study looks at whether giving long-acting injectable HIV medication and birth control (like implants or shots) together is safe and works well for adolescent girls and young women living with HIV in Kenya. About 700 participants aged 15-24 will either get the long-acting HIV…

This study tests whether wearing specialized soft contact lenses for short periods each day can slow the worsening of nearsightedness (myopia) in children. About 80 kids who already wear contacts will use either one type of lens or two types on different days for a year. Research…

This study tests a lower daily dose of the chemotherapy drug capecitabine in 40 patients aged 60 or older, or those who are frail, with advanced breast cancer. The goal is to see if this gentler approach can still shrink tumors or slow the disease while being easier to tolerate. …

This study looks at whether a 24-week live online exercise program set to music can improve heart health in 132 adult wheelchair users. It compares the live program to standard exercise videos. The goal is to reduce risk factors like waist size, blood sugar, and cholesterol. A 12…

This study is for people with advanced non-small cell lung cancer that does not have the PD-L1 protein, making it harder to treat. Researchers want to see if using two different immunotherapy drugs together with chemotherapy works better than just one immunotherapy drug with chem…

This study tests whether adding a 2mm safety margin around brain tumors during radiosurgery (a precise radiation treatment) works better than no margin. About 180 adults with brain metastases up to 4cm will be randomly assigned to one of the two margin sizes. The goal is to see w…

This study tests a new automated method to select specific stem cells (CD34+) for transplant in people with blood cancers like leukemia or lymphoma. The goal is to lower the risk of graft-versus-host disease, a serious complication where donor cells attack the patient's body. Abo…

This study tests whether a patient navigator who guides older adults to bone health care can reduce the chance of another broken bone after a fragility fracture. About 2,634 people aged 50 and older who recently broke a bone from a minor fall will be assigned to either the naviga…

This study tests whether metformin, a common diabetes drug, can lower inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, with or without HIV. Participants will take metformin or a placebo for 16 weeks and have their immune …

This study looks at whether a blood test that detects leftover cancer DNA can help decide who needs additional treatment after kidney cancer surgery. About 100 people with high-risk clear cell kidney cancer will join. Those with no detectable cancer DNA will skip standard immunot…

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. Researchers will measure how many extra days women stay pregnant before delivery. The goal is to reduce risks for both m…

This study tests whether a special dental gel, used at home, can improve gum health more than standard care alone in people with moderate to severe gum disease (periodontitis). About 76 adults will use the gel after a deep cleaning and be followed for 6 months. The main goal is t…

This study looks at whether a low-carbohydrate diet can improve blood sugar control in teenagers with type 2 diabetes compared to a standard diet. About 40 teens aged 12-18 will follow one of the two diets for 24 weeks. The goal is to see if the low-carb approach leads to better …

This study tests a telehealth program called C-READY that aims to improve thinking skills and self-management in 120 teens with sickle cell disease. Participants will complete online exercises and coaching to help them prepare for transitioning from pediatric to adult healthcare.…

This study tests a 24-week church-based program for Black men aged 35-70 who are at risk for heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get one-on-one support, and use smart devices to track progress. The goal is …

This study tests whether giving a DHA supplement early to very preterm babies who are small at birth can improve head growth without increasing body fat. About 152 babies will receive either DHA or a placebo. The goal is to see if this simple nutrient can support brain developmen…

This study tests whether a new way of giving three drugs (ATG, tacrolimus, and methotrexate) can prevent a serious side effect called graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial will enroll 29 adults aged 18-60 who have a matched don…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure can stick with and enjoy. About 50 women aged 40 and older will take part. The goal is to see if the program is acceptable and helps with blood pres…

This study looks at whether treating mild high blood pressure (stage 1) in pregnant women can improve baby birth weight. 74 pregnant women with blood pressure between 130-139/80-89 mmHg will be split into two groups: one gets medication to keep blood pressure below 130/80, and th…

This study is for people newly diagnosed with multiple myeloma, a type of blood cancer. It uses a sensitive test to measure tiny amounts of leftover cancer cells (MRD) after initial treatment. Depending on the results, patients may receive less intensive therapy or a combination …

This study looks at whether eating only during the early part of the day (early time-restricted eating) can improve heart health and daily body rhythms in older adults with high blood pressure. Researchers will track blood sugar, heart rate variability, and blood pressure in 30 p…

This study tests a treatment for people with aggressive brain tumors (glioblastoma, anaplastic astrocytoma, or gliosarcoma) that have come back or are newly diagnosed. The treatment combines a genetically modified herpes virus (M032) that delivers an immune-boosting protein (IL-1…

This early-phase study tests a combination of two drugs, mogamulizumab and brentuximab vedotin, in people with a rare type of skin lymphoma (CTCL or MF) that has been treated before. The main goal is to find a safe dose and see how well the combination is tolerated. About 10 adul…

This study tests a combination of three drugs (carboplatin, paclitaxel, and pembrolizumab) given before surgery to shrink tumors in people with newly diagnosed stage III or IV ovarian cancer. After surgery, participants receive more chemotherapy plus two maintenance drugs (olapar…

This study tests whether intravenous immunoglobulin (IVIG) can help people with a rare autoimmune muscle disease called anti-HMGCR IMNM. The disease causes muscle weakness and damage. The trial will include 12 adults with active disease who will receive either IVIG or a placebo e…

This study tests two different triple-combination inhalers in 20 adults with moderate to severe asthma that is not well controlled. Researchers will use special MRI scans to see which drug reaches the small airways better and improves breathing. The goal is to find out which trea…

This study tests whether people newly diagnosed with multiple myeloma or amyloidosis can safely postpone a stem cell transplant if they achieve a very deep response (called minimal residual disease negativity) after 6 cycles of a powerful drug combination. About 40 participants w…

This study tests a combination of services—telehealth check-ins, a peer support specialist, the medication buprenorphine, and help connecting to long-term care—for people who have had an opioid overdose and visited the emergency department. The goal is to keep participants in tre…

This study tests a new drug combination (carboplatin and mirvetuximab) as the first treatment for people with advanced ovarian, fallopian tube, or peritoneal cancer that has a specific marker (folate receptor alpha). About 70 participants will receive the drugs before and after s…

This study compares a new breast biopsy marker (HydroMARK Plus) with the current standard marker to see which one surgeons can find and remove more successfully during breast surgery. About 150 adults with breast tumors who are scheduled for surgery will take part. The goal is to…

This study tests whether a new metal rod that allows tiny movements helps shinbone fractures heal better than the standard rod. About 100 adults with stable shin fractures will be randomly assigned to one of the two rods. The main goal is to see which rod leads to faster bone hea…

This study tests whether a new EDTA mouth rinse helps gums heal better after tooth extraction and bone grafting compared to standard rinses like chlorhexidine and essential oil. About 40 adults who need a single tooth pulled and bone grafted will use one of the rinses. Researcher…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study is testing three custom-designed stents to treat complex aneurysms in the main artery (aorta) that standard devices cannot fix. The goal is to see if these less-invasive stents can lower the risk of death, lung problems, and hospital stay compared to open surgery. Abou…

This study tests whether sending high-risk infants home with a special pulse oximeter (Owlet OSS 3.0) after NICU discharge can reduce emergency room visits and serious rehospitalizations. About 700 babies who no longer need oxygen support will be randomly assigned to standard car…

This early-stage study tests whether adding two drugs, decitabine and venetoclax, to a standard stem cell transplant can make the procedure safer for people with aggressive blood cancers like leukemia. About 20 adults aged 18-75 with a matched donor will receive the experimental …

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural nighttime drop in blood pressure in people with obesity. Obese individuals often have high nighttime blood pressure, which raises their risk for heart problems. Res…

This early-stage trial tests whether two vaccines, given as a shot, are safe for people with a long-lasting HPV16 infection that has caused mild cervical cell changes. About 30 adults will receive the vaccines to find the best dose and check for side effects. The goal is to help …

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study aims to find the best combination of strategies to help people maintain weight loss after losing weight. Over 500 adults with obesity will first lose weight through a 16-week program, then try different support methods—like limiting food variety, home strength training…

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study tests a drug called pirfenidone, currently used for lung disease, to see if it can safely reduce repeat attacks of pancreatitis. About 60 adults who have had two or more pancreatitis attacks will receive either the drug or a placebo. Researchers will track side effects…

This study tests whether the antibiotic azithromycin can help children with severe RSV infection who need breathing support in the ICU. Researchers want to see if it shortens hospital stays and reduces time on oxygen. About 370 children will take part, receiving either azithromyc…

This study tests a two-step method of giving an anti-rejection drug (ATG) along with standard medications to prevent severe graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 56 adults aged 18-75 will participate. The goal is to …

This study tests a program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults who had a confirmed gout flare in…

This study is testing a new ultrasound technique called Shear Wave Elastography to see if it can detect acute kidney injury early in people who have had vascular surgery. Researchers will compare the kidney stiffness measurements of 50 healthy volunteers and surgery patients. The…

This study aims to see if a Pap smear that women collect themselves is just as accurate as the traditional one done by a healthcare provider. Researchers will enroll 250 women aged 21-65 who need routine cervical cancer screening. If successful, this approach could make screening…

This study tests whether a dye called panitumumab-IRDye800 can make head and neck cancer cells glow during surgery, helping surgeons see and remove them more accurately. About 25 adults with head and neck cancer who are already scheduled for surgery will receive the dye beforehan…

This study is testing a new way to diagnose biliary atresia, a serious liver condition in newborns where bile ducts are blocked. Infants with jaundice will receive a one-time injection of a safe dye (ICG), and their diapers will be checked for a glow that indicates bile flow. The…

This study is testing whether an AI-assisted eye screening program at community health centers can help detect glaucoma and other eye conditions early. About 1,800 adults at higher risk for eye disease will receive a quick screening using AI tools. Researchers will compare detect…

This study explores whether a tampon can collect samples to detect endometrial (uterine) and ovarian cancer early. Researchers will analyze DNA and proteins from tampons used by 1,500 women before surgery. The goal is to develop a simple, non-invasive test that could catch these …

This early-phase study tests a new PET scan that uses a radioactive tracer (89Zr-trastuzumab) to see how much HER2 protein is in breast cancer tumors. The goal is to find out if this scan can predict which patients will respond to HER2-targeted therapy. About 10 adults with newly…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems delay or prevent dementia. About 1,300 people aged 55–89 with mild cognitive impairment will try different combinations of cognitive training or general mental stimulatio…

This study looks at whether spending extra time in a kangaroo mother care (KMC) ward—where mothers hold their babies skin-to-skin—can lower the risk of postpartum depression. About 1,900 mothers and their low birthweight infants in Zambia will be randomly assigned to either stand…

This study tests a data dashboard that helps clinics in Alabama track and improve access to PrEP, a daily pill that prevents HIV. Researchers will work with 7 clinics to see if the dashboard helps more Black patients get PrEP and reduces racial gaps in prevention. The study invol…

This study tests whether a medication called misoprostol can help doctors get a clearer view of the cervix during cancer screening. About 420 non-pregnant women aged 25 and older who have a hard-to-see cervix will receive either misoprostol or a placebo. The goal is to see if the…

This study tests whether giving selumetinib early to children aged 1 to 8 with NF1 can prevent plexiform neurofibromas from growing and causing serious issues like pain or blindness. Half the children will receive the drug, while the other half will be observed. The goal is to se…

This study tests whether a DASH-style diet (rich in fruits, vegetables, and low-fat dairy) can reduce the risk of forming new kidney stones. About 48 adults with a history of kidney stones will eat either a DASH diet or a typical Western diet for one week, with all meals provided…

This study tests whether teaching people how to use mobility devices like crutches or walkers before foot or ankle surgery can reduce the number of falls after the operation. About 250 adults having elective foot or ankle surgery will be enrolled. Half will receive standard care,…

This early study tests the drug ivacaftor in 20 adults with chronic sinusitis and gram-negative bacteria that didn't get better with standard treatment. The goal is to see if the drug is safe and can improve sinus symptoms and quality of life. Participants will take the drug for …

This study tests whether combining a ketogenic diet supplement with online brain training can improve thinking skills in blood cancer survivors. About 80 adults with mild to moderate memory or focus problems will be randomly assigned to either start the program right away or wait…

This study tests whether a personalized exercise program using motion-controlled video games (like Nintendo Switch) can help head and neck cancer survivors reduce fatigue and pain after treatment. 150 participants who have finished radiation or chemotherapy will be assigned to ei…

This study compares carbon dioxide gas versus regular air for inflating the belly during children's endoscopy procedures. The goal is to see if CO2 reduces pain, bloating, and gas after the test. About 350 children aged 6 months to 18 years will take part. The study focuses on co…

This study tests whether a gentle, non-invasive nerve stimulation called taVNS can improve how the body controls heart rate and blood pressure in people with Parkinson's disease. 24 participants will receive taVNS while performing simple physical tasks. The goal is to see if this…

This study tests whether bright light therapy can improve sleep and brain function in people recovering from opioid use disorder. About 105 adults on stable opioid medication will receive either bright or dim light for 30 minutes each morning over two weeks. Researchers will meas…

This study tests a therapy called Constraint-Induced Movement Therapy for adults who had a stroke at least 6 months ago and have mild weakness in one arm. The therapy involves daily training sessions to improve arm use, along with techniques to encourage using the weaker hand in …

This study tests whether adding a cocoa supplement to regular exercise helps older adults (55+) with slow walking speed improve their physical performance and muscle strength more than exercise alone. Participants will take cocoa or a placebo while doing exercise training for sev…

This study looks at whether sitting ARDS patients upright in bed can improve their breathing while on a ventilator. Researchers will compare upright positioning to standard care in 40 adults. The goal is to see if this simple change can make a difference in how well the lungs wor…

This study is testing a 5-session radiation treatment (stereotactic body radiotherapy) for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and causes fewer side effects than standard longer radiation. Abou…

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in women with gynecologic cancer. About 64 participants will use the app and have their brain function measured with tests and surveys. The goal is…

This study is testing whether a 6-week virtual magic trick training program can help adolescents with autism improve their social and emotional skills. About 60 teens aged 11 to 18 with a confirmed autism diagnosis will take part. They will learn magic tricks online and researche…

This study tests whether acceptance and commitment therapy (ACT), a form of talk therapy, can help adults with religiously focused obsessive-compulsive disorder (OCD). Ten participants will receive ACT and report changes in their symptoms. The goal is to see if this therapy is a …

This study tests a new training program to help people quit smoking by managing the negative feelings and withdrawal symptoms that often lead to relapse. Researchers will enroll 400 adult smokers who want to quit. The program focuses on teaching skills to handle early withdrawal …

This study tests a therapy called ReACT for teens aged 11-18 who have psychogenic non-epileptic seizures (PNES), which look like seizures but aren't caused by epilepsy. The therapy focuses on changing thoughts and behaviors to help teens feel more in control and reduce fear of sy…

This study is testing whether adding sensory training to a standard arm therapy (Constraint-Induced Movement therapy) helps stroke survivors use their affected arm and hand more in daily life. The therapy involves intensive practice and temporarily restraining the less-affected a…

This study tests a program that gives cancer patients free legal help with issues like insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will receive legal navigation and be followed for 6 months. Researchers want to see if this reduc…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help reduce chronic pain and other symptoms in people with fibromyalgia. About 30 women aged 25-65 with long-term widespread pain will receive psilocybin in a controlled setting. Resear…

This study explores whether watching virtual reality nature scenes can lower stress in adults with mobility impairments. Researchers will measure stress through surveys and saliva samples. The goal is to find a simple, accessible way to help this group manage stress.

This study tests whether taking an oral medication called tranexamic acid after shoulder replacement surgery can reduce pain and improve short-term recovery. Researchers will compare outcomes in 60 adults aged 18-79 who are having their first shoulder replacement. The goal is to …

This study looks at whether a computer brain-training program called Lumosity can help improve memory and thinking in people who have had a stem cell transplant for blood cancer. About 60 adults who are 3 to 6 months post-transplant will either start training right away or wait 1…

This study tests whether a 10-week online writing program, guided by a coach, can help adults with spinal cord injury process grief and improve emotional well-being. Researchers will measure changes in grief, stress, depression, sleep, and resilience. The study aims to enroll 60 …

This study tests whether injecting a numbing medicine and steroid near a nerve in the throat can reduce coughing and improve quality of life for people with chronic cough caused by nerve issues. About 50 adults with cough lasting 8 weeks or more will receive the injection in a do…

This study tests whether special tinted contact lenses can reduce light sensitivity in people who have had a mild concussion. Researchers will enroll 60 adults who have had a concussion within the last two years and currently experience light sensitivity. Participants will try da…

This study looks at the best time to place a small mesh sling during robotic surgery for pelvic organ prolapse. The sling helps stop urine leakage when coughing or laughing. Researchers will compare placing the sling before or after lifting the vagina to see which timing works be…

This study tests a therapy called ReACT for children aged 11-18 who have psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but have no medical cause. The therapy focuses on changing thoughts and behaviors to help children feel more in control and reduce…

This study compares two 30-hour cognitive rehab programs for 30 adults with long COVID who have mild to moderate brain fog. Both programs use computer games, in-person training, and a mild nerve stimulation device. One program focuses on thinking skills and work tasks, while the …

This study aims to help young people with Down syndrome (age 12 and older) and their caregivers sleep better and feel better. Researchers will adapt a virtual mindfulness program for insomnia and test it in a small trial with 20 participants. The goal is to see if the therapy imp…

This study tests a new mind-body treatment called ReACT for teenagers aged 11-18 who have functional seizures (seizures not caused by epilepsy). Participants will be randomly assigned to either ReACT or a comparison therapy for 12 sessions. The goal is to see if ReACT is practica…

This study looks at brain activity related to non-motor symptoms like attention and thinking in people with Parkinson's disease. Researchers will record brain surface signals during routine deep brain stimulation surgery. About 140 participants who are already scheduled for surge…

This study follows 35 people who recently had a spinal cord injury to see how their gut bacteria change over the first year. Researchers will collect blood, stool samples, and bowel function surveys at the start, 6 months, and 12 months. The goal is to understand how the gut micr…

This study looks at the best ways to help people with physical disabilities stick to a home exercise program. Over 32 weeks, 257 participants will get access to exercise videos and wellness articles. Some will also receive health coaching calls, and if they aren't active enough a…

This study uses a special PET scan to look for brain inflammation in people with long COVID who have neurological symptoms like brain fog or headaches. Researchers will compare 60 participants (both long COVID patients and healthy volunteers) to see if inflammation is linked to t…

This study looks at whether people with a genetic mutation that causes alpha-1 antitrypsin deficiency (AATD) also have changes in nearby genes that might weaken their immune system and lead to more lung infections. Researchers will compare immune responses to a pneumonia vaccine …

This study looks at how the brain manages emotions when facing a threat. Researchers will record brain activity and use mild electrical stimulation in people with epilepsy who already have electrodes implanted for medical reasons. The goal is to understand brain connections invol…

This study is creating a biobank—a collection of DNA samples and health information—from 500 adults. Researchers will use this resource to study genetic links to heart disease, high blood pressure, diabetes, and obesity. The goal is to provide a valuable tool for future medical d…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and viruses change over time. Participants join when diagnosed or starting standard antiviral treatments and are monitored for years. The goal is to understand the disease better,…

This study looks at how vision loss from glaucoma impacts the ability of older adults to move around and go places (called 'life space'). Researchers will measure vision under dim light and compare it to how far and how often participants leave their homes. The goal is to underst…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity. Researchers will compare six groups of people (cisgender men, cisgender women, transgender men and women, with or without hormone therapy). Participants will undergo pain tests, provide b…

This study looks at whether a partial problem with a protein called CFTR (which helps control salt and water movement in the body) contributes to chronic sinusitis. Researchers will measure how well the nose clears mucus in 20 people with chronic sinusitis and compare them to hea…

This study uses a special PET scan to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will track changes over two years to see how inflammation relates to disease progression. The goal is to better understand…

This study tests whether an augmented reality headset (Microsoft HoloLens 2) can help doctors place IVs and catheters more successfully. About 50 people who need ultrasound-guided vascular access will take part. Researchers will measure success rates, number of needle sticks, and…

This study looks at how childhood trauma and stress might change tiny genetic molecules called microRNAs in the blood. Researchers hope these changes can help explain why some people develop depression or suicidal thoughts. 450 adults aged 18-60 with or without depression will gi…

This study follows 40 people who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will measure strength and mobility with simple tests and look at how hospital readmissions affect recovery. The goal is to learn m…

This study aims to better understand the inflammatory genes involved in psoriasis, a chronic skin condition. Researchers will analyze genes like TNF-alpha and IL-6 in 13 adults with psoriasis. The goal is to find better ways to measure and manage the disease, not to test a new tr…

This study looks at how the brain works during thinking tasks like remembering or paying attention. Researchers will record brain activity from 30 adults with epilepsy who are already having brain surgery for seizures. The goal is to better understand conditions like dementia, AD…

This study looks at how people with severe vision loss from macular degeneration can train their brains to use their remaining side vision more effectively. Researchers will measure changes in visual skills after about 7 weeks of training. The goal is to learn more about brain pl…

This study is building a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will collect information on frailty, muscle loss, and other age-related health issues. No treatments are given—the goal is to gather data to supp…

This study looks at how much oxalate the body naturally produces in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver. Researchers will measure oxalate levels in urine after participants eat a special low-oxalate diet. The goal is…

This study looks at whether a fast genetic test can help doctors choose the best blood-thinning medicine for people who have had a minor stroke or a high-risk transient ischemic attack (TIA). About 200 adults admitted to the hospital will provide a cheek swab for DNA testing. The…

This study trains palliative care doctors to better understand and address racism in healthcare. Researchers will work with 60 African American patients and their families to see if using storytelling videos and bias training improves the quality of care. The goal is to make end-…

This study looks at whether activating a protein called LXR can help prevent diabetic retinopathy, a common eye problem in people with diabetes. Researchers will test blood cells from 104 adults with and without diabetes to see how LXR affects cell repair and inflammation. The go…

This study is testing whether a single 5-minute exposure to a specific type of light (670 nm) can increase blood flow in the calf muscles of people with peripheral artery disease (PAD). Researchers will measure blood flow using ultrasound and take blood samples to check for nitri…

This study looks at 1000 adults in Latin American ICUs who need dialysis for sudden kidney failure. Researchers want to understand how care differs between countries and what affects patient survival. The goal is to gather data to improve future treatment, not to test a new drug …

This study looks at whether a common breathing test (spirometry) can help doctors decide the right dose of immunoglobulin therapy for people with common variable immune deficiency (CVID) who also have mild airway blockage. About 22 adults on stable therapy will be split into two …

This study uses a special PET scan to measure tau protein buildup in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau levels relate to memory, genetics, race, and blood vessel health. Participants are already part of a larger Alzheimer's study an…

This study looks at tiny particles called exosomes released from the placenta that may cause preeclampsia, a serious pregnancy condition. Researchers will collect blood and tissue samples from 64 women with preeclampsia and study these particles in the lab and in animals. The goa…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study uses a special brain scan (PET/MRI) to measure inflammation in the brains of people with Parkinson's disease and compare it to healthy volunteers. The goal is to see if people with Parkinson's have higher levels of brain inflammation. No treatment or medication is give…

This study looks at whether a single dose of a ketone drink can quickly improve brain function, reaction time, and driving skills. Researchers will compare results in three groups of adults aged 19 to 55: people with obesity who are inactive, lean people who are inactive, and lea…

This study looks at whether shining red light on the leg can change blood flow in healthy adults. 40 participants will receive red light and an ultrasound dye to measure blood flow. The goal is to understand how light affects the body, not to treat any disease.

This study explores how a natural heart hormone, called natriuretic peptide, influences metabolism and exercise in people with different genetic makeups. Researchers will measure hormone levels and energy use in 200 adults after a sugary drink and exercise. The goal is to underst…

This study looks at whether a community-based program can help cancer survivors and their loved ones eat healthier and exercise more. About 100 adults in the Birmingham area who have had cancer or are close to a cancer survivor will take part. The program adapts proven health tip…

This study looks at whether high-intensity exercise can help older adults with HIV improve their thinking and memory, and make exercise a lasting habit. Researchers will enroll 110 sedentary people with HIV who report fatigue. Participants will join a supervised exercise program …

This study looks at how vitamin C (ascorbic acid) breaks down into oxalate, a key component of kidney stones. Researchers will give a special labeled vitamin C to 136 adults, both with and without kidney stones, and measure how much turns into oxalate in urine. The goal is to und…

This study tests a combination program to improve HIV testing, get people into care quickly, and help them achieve viral suppression. Researchers will work with health departments in coastal Alabama to use data to target testing, connect people to care at diagnosis, and start tre…

This study looks at whether a ketogenic diet can increase the number of calories your body burns each day and help control appetite after you've lost weight. Researchers will enroll 20 adults with obesity who are otherwise healthy. Participants will follow a keto diet, and their …

This study looks at how the brain makes sense of sentences. Researchers will work with 153 epilepsy patients who already have electrodes in their brains for medical reasons. Participants will read or listen to sentences while their brain activity is recorded, and in some cases, m…

This study looks at how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Researchers will record brain signals during DBS surgery to create detailed maps that could help doctors target the right brain areas and program the device more precis…

This study tests whether a special PET/MRI scan can track how immunotherapy affects triple negative breast cancer. About 20 patients will get the scan before and during their regular treatment, but the scan results won't change their care. The goal is to see if the scan can predi…

This study looks at how eating potatoes with or without herbs and spices affects blood sugar levels in healthy adults. Researchers will use a continuous glucose monitor to track changes for about 2 hours after a meal. The goal is to see if this monitoring method can detect differ…

This study looks at whether telling people their genetic risk for high blood pressure helps them make healthier choices and lower their blood pressure. Researchers will give some participants their genetic risk score along with counseling, while others get standard care. The goal…

This study looks at how to set the breathing machine (ventilator) for very premature babies (born before 34 weeks) who need help breathing. Researchers will test different pressure levels to see which one helps the heart pump blood best and improves oxygen levels. They will use s…

This study tests a new type of PET/MRI scan to see if it can find active high-grade glioma (a serious brain cancer) in children and adults after they finish standard radiation therapy. About 20 participants will get the special scan, and doctors will follow them for up to 2 years…

This study tests different ways to help people with advanced chronic kidney disease and their caregivers work together when making health decisions. About 128 patient-caregiver pairs will receive coaching sessions to improve communication and support skills. The goal is to find t…

This study looks at how a financial counseling program for cancer patients affects their money stress, quality of life, and emotional distress. Researchers will review surveys and medical records from about 40 patients and staff at the University of Alabama at Birmingham. The goa…

This study looks at whether pumping breast milk more often (every 2 hours vs every 3 hours) helps mothers of preterm babies produce more milk. About 70 mothers will be assigned to one of two pumping schedules and record their daily milk volume for the first 28 days after birth. T…

This study compares a new type of PET scan using 89Zr panitumumab with the standard FDG-PET scan to see which one better shows the size and location of head and neck cancers. About 14 newly diagnosed patients will get both scans before surgery. The results are for research only a…

This study looks at how a sticky protein called amyloid builds up in the brains of people with Alzheimer's disease. Researchers will use special PET scans to measure amyloid levels and see how they relate to a person's race and heart health. The goal is to better understand Alzhe…

This study looks at whether giving very premature babies (born 27-31 weeks) a higher or lower amount of human milk helps them grow better and have healthier guts. About 486 babies will be randomly assigned to one of two milk volumes. The goal is to find the best feeding plan for …

This study tests if playing with finger puppets can help preterm infants develop better. Caregivers will use puppets to get the baby's attention and encourage communication. The study will compare babies who do this plus standard care to those who only get standard care. About 18…

This study tests a new program to help Black and Latinx adults with rheumatic diseases get the updated COVID-19 vaccine. About 1,170 participants will receive a patient-directed behavioral intervention in rheumatology clinics. The goal is to see if this approach increases vaccina…

This study aims to understand how oxalate, a natural substance in many foods, contributes to kidney stone formation and affects the immune system. Researchers will enroll both healthy volunteers and people with calcium oxalate kidney stones. Participants will follow a controlled …

This study looks at how spinal cord stimulators change nerve signals and symptoms in people with restless leg syndrome (RLS) and chronic pain. Researchers will use brain and nerve tests to measure these changes. The study includes 50 adults with RLS, chronic pain, or both, and ai…

This study looks at how early childhood experiences—like stress, social factors, and breastfeeding—affect the health of children with sickle cell disease. Researchers will enroll 20 mothers and their infants in Birmingham, Alabama. The goal is to learn whether a community-based b…

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during and after deep brain stimulation surgery. The goal is to understand the brain's role in movement p…

This study looks at lymphoma patients who also develop a serious immune condition called HLH. Researchers will collect data from 2,000 participants to see which treatments and factors help patients live longer. The goal is to find better ways to treat this rare complication.

This study explores whether special stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will take blood from 20 people with diabetes and healthy volunteers to create these stem cells in a lab. The …

This study looks at whether using a special saw during a common jaw surgery changes the way the inner bone breaks. About 40 people having jaw surgery will be included. The goal is to find out if the saw leads to more predictable and favorable bone fractures, which could help surg…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers will test special light-sensitive cells in the eye that help control sleep and body rhythms. The goal is to find new ways to improve sleep and reduce relapse. About …

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory or mood chang…

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…

This study aims to see if a special coaching program for parents, focused on early literacy and numbers, helps improve their baby's learning and development scores by age 2. It will compare babies whose parents receive this extra coaching plus shared reading training to babies wh…