University Of Alabama At Birmingham

This study tested an enhanced football-based program for over 2,000 teenage girls in Zambia. The program added HIV self-testing, birth control information, and access to a nurse to the usual soccer activities. The goal was to see if this would increase HIV testing and use of cont…

This study tested a simple tool that helps doctors choose the best smoking cessation medications for their patients with HIV. 371 smokers living with HIV took part. The goal was to see if the tool helped more people quit smoking for at least 7 days.

This study tested whether 10 weeks of moderate or intense exercise could improve overall brain health and lower blood pressure in adults aged 35-65 with hypertension and a BMI of 25 or higher. Participants used smartphone apps to track workouts and had their brain care score, blo…

This early-phase study tested an oral drug called NTX-301 in 22 adults with blood cancers (MDS, AML, or CMML) that had not responded to prior treatment. The main goal was to check safety and find the right dose. Researchers also looked for signs that the drug could control the di…

This study tested two weight loss programs in 223 adults with overweight or obesity. One group followed a fixed daily calorie limit, while the other varied their calorie intake day-to-day. The goal was to see which approach leads to more weight loss.

This study tested whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with therapy could help people reduce or stop using cocaine. Forty adults who wanted to quit cocaine took either psilocybin or a placebo in a controlled setting. Researchers …

This study tested whether a personalized lifestyle program could help adults with insulin resistance, obesity, diabetes, or related conditions improve their metabolic health. Forty participants first received either nutrition or exercise counseling. Those who didn't improve after…

This study tested a smartphone program that uses artificial intelligence and game-like features to help people with type 2 diabetes manage their blood sugar. 88 adults took part for 6 months. The goal was to see if the program was easy to use and could help lower A1C levels, espe…

This study looked at whether weighing yourself every day can help adults with obesity stop gaining weight. About 400 people received an electronic scale and were asked to weigh themselves daily. The goal was to see if this simple habit, supported by their primary care clinic, cou…

This study tested a treatment for people with idiopathic pulmonary fibrosis (IPF) who experience sudden, severe worsening of their condition. The treatment combined plasma exchange, rituximab, and intravenous immunoglobulin to target harmful antibodies. The goal was to improve su…

This study tested a new AI-assisted telecoaching program to help people with type 2 diabetes and physical disabilities better manage their blood sugar. 90 participants completed the program, which focused on personalized lifestyle changes and family support. The goal was to see i…

This study tested whether counseling can help people living with HIV in Zambia reduce unhealthy alcohol use and improve their HIV control. About 680 adults were split into three groups: a brief counseling session, brief counseling plus more in-depth therapy, or standard care. The…

This study tested a two-step treatment for medium-sized kidney tumors (4.1-7 cm). First, doctors blocked the tumor's blood supply, then froze it. The goal was to see if this approach is safe and works well. 25 adults with stage T1b kidney cancer took part. The main focus was on s…

This study tested a combination of two drugs, veliparib and lapatinib, in 20 people with metastatic triple negative breast cancer that had already been treated. The goal was to see if the combination was safe and could shrink tumors. Participants received both drugs, not a placeb…

This study looked at whether having a peer coach—someone like you who has lost weight—can help people with obesity lose more weight than trying on their own. 375 adults with a BMI between 30 and 50 took part. The program used phone calls and group sessions to support healthy eati…

This early-stage study tested whether adding a new drug called LDE225 to a standard chemotherapy (paclitaxel) is safe for women with ovarian cancer that no longer responds to platinum-based treatments. Fifteen women took part to find the best dose and monitor side effects. The go…

This pilot study tested two health coaching strategies for Black adults with stage 1 obesity and conditions like high blood pressure, prediabetes, or high cholesterol. One strategy focused on weight loss, while the other focused on increasing physical activity without targeting w…

This study looked at 45 adults with osteoporosis caused by long-term steroid use. Participants had been taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which switch timing best controlled bone turnover and preven…

This study tested a combination of three drugs (letrozole, everolimus, and TRC105) given before surgery to 15 postmenopausal women with hormone-receptor-positive, HER2-negative breast cancer. The goal was to see if the drugs were safe and could shrink tumors. The approach targets…

This study looked at whether limiting when you eat (time-restricted eating) can improve blood sugar and heart health in adults with prediabetes. 108 participants were assigned to eat only between 8am-3pm, 1pm-8pm, or a normal 12-hour window for 8 weeks. All meals were provided an…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing difficult. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Resear…

This study tested the drug crizotinib in 12 people with neurofibromatosis type 2 (NF2) who had growing tumors on their hearing nerves. The goal was to see if the drug could shrink these tumors. Participants took crizotinib pills daily for up to 12 months. The study is now complet…

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that scars the eye and can lead to blindness. The goal was to see if rituximab could stop further scarring when standard treatments had failed. The study mea…

This study tested whether artificial intelligence (AI) can help doctors spot breast tumors on MRI scans that use a lower dose of the contrast agent gadolinium. Twenty women—half with benign findings and half with breast cancer—received both a standard-dose and a low-dose MRI. The…

This study tested a portable device called the Infrascanner to see if it can accurately monitor bleeding in the brain after a traumatic injury. 399 patients with a confirmed brain bleed on their first CT scan were enrolled. The goal was to see if the scanner could detect when a b…

This study tested whether applying two FDA-approved creams (diclofenac and DFMO) to the skin can prevent new non-melanoma skin cancers in people who have already had one. 64 adults with a history of skin cancer and current actinic keratoses (precancerous spots) used either the cr…

This study looked at how to make HIV prevention medication (PrEP) more available to women during their regular gynecology visits. Researchers surveyed and interviewed over 1,300 patients and their healthcare providers to understand what works best. The goal is to help more women …

This study tested whether teaching pregnant women about personal hygiene can reduce their risk of catching cytomegalovirus (CMV) and passing it to their baby. Researchers enrolled 200 women in Brazil who were already immune to CMV. The goal was to see if this counseling could cut…

This study tested whether a topical medication called diclofenac can reverse certain biomarkers in the skin to prevent non-melanoma skin cancers. 24 participants applied the cream once or twice daily to see if it reduced these biomarkers. The goal was to find the best dose for pr…

This study tested a program where male-female health worker pairs visited pregnant women and their male partners at home in Kenya. The goal was to encourage couples to test for HIV together and improve family health. About 1,600 pregnant women and their partners took part, and th…

This study tested a school program to help middle school students in Southeast Alaska learn how to avoid paralytic shellfish poisoning (PSP). About 50 students took part in lessons that combined cultural practices, science, and safety tips. The goal was to change their behaviors …

This study tested whether a short, clinic-based talk about reducing risk of cytomegalovirus (CMV) could prevent pregnant women from catching the virus. CMV is a common virus that can harm unborn babies. The study enrolled 582 pregnant women and compared those who received the tal…

This study tested a telephone-based exercise counseling program to help people in rural Alabama become more physically active and lower their cancer risk. 245 adults who were not very active took part. The program used phone calls and automated reminders to support increasing mod…

This study tested a program to help young Black men who have sex with men start taking PrEP, a daily pill that prevents HIV. Participants used a mobile app and some also joined weekly group talks led by Black women from their community. The goal was to see if this approach made i…

This study tested a communication tool to help women at risk for HIV learn about PrEP (a daily pill that prevents HIV) and get referrals to clinics. 67 HIV-negative women in rural Alabama participated. The goal was to see if the tool was easy to use and if it helped more women st…

This study tested a simple checklist for hospital staff to help people who inject drugs get HIV prevention medicine (PrEP) and addiction treatment. Researchers worked with 60 HIV-negative adults with opioid use disorder at a hospital in Alabama. The goal was to see if this approa…

This study tested whether a video-based exercise program is practical and acceptable for adults with cystic fibrosis after a flare-up. Nine participants tried the program at home via telehealth. The goal was to see if patients would join and stick with it, not to measure health i…

This study looked at whether a non-invasive nerve stimulation (like a gentle pulse on the ear) combined with physical therapy could help people with Parkinson's disease move better and feel better. Twenty-five adults with mild-to-moderate Parkinson's took part. The goal was to se…

This study tested a telephone-based nurse coaching program for older adults (age 60+) with moderate to very severe COPD and their care partners. The program, called EPIC, provided six sessions for patients and four for care partners, focusing on palliative care and quality of lif…

This study tested a high-intensity home exercise program for 42 children with cerebral palsy. The program involved rhythmic arm movements to music, adapted for wheelchair use. The goal was to see if it could improve cardiorespiratory fitness and heart health. Parents helped suppo…

This study looked at whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. Seventy women were randomly assigned to receive either standard enhanced recovery care or a QL block. The main g…

This study tested a program to help people over 50 living with HIV build resilience and better handle daily stress. 106 participants from an HIV clinic took part. The program used daily text messages to track how they coped with stressors and their emotional reactions. The goal w…

This study tested a new FDA-approved sedative, remimazolam, against the standard drug propofol for patients having a heart imaging test called TEE. The goal was to see if remimazolam provides better blood pressure stability and faster recovery. 105 adults participated, and resear…

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases (tumors that spread to the brain from other cancers). It included 13 adults with tumors between 2 and 6 cm. The goal was to find the highest dose that does not c…

This early-stage study tested an oral medication called deucravacitinib for treating nail psoriasis in adults. Researchers measured how much the nails improved over 48 weeks using a special severity score. Only one person was enrolled, so results are very limited.

This study tested whether an 8-week virtual reality gaming program that combines exercise and mindfulness can help children with cancer be more active and feel better overall. Eleven kids participated, either starting the program right away in the hospital or waiting 8 weeks afte…

This study tested a 12-week exercise program set to music for 108 adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants were split into two groups: one did the music-based exercise, the other waited. The goal was to see if this fu…

This study tested a structured educational program called the Myeloma Pack for people with multiple myeloma. The goal was to see if learning more about their disease could reduce anxiety and depression and improve quality of life. 85 patients participated alongside their regular …

This study looked at whether delivering healthy meals to low-income women with obesity after childbirth is practical and helpful for weight management. Eleven women who had recently given birth received weekly meal deliveries and reported how much they ate. The goal was to see if…

This study tested a special diabetes education program for adults with Type 2 diabetes and physical disabilities like spinal cord injury or multiple sclerosis. The program included nutrition advice and self-management skills, delivered in an accessible way. Researchers measured c…

This study tested whether starting a structured exercise program combined with behavioral counseling during a hospital stay is feasible for adults with cystic fibrosis. Three participants joined the program while hospitalized for a lung flare-up. The goal was to see if this appro…

This study looked at whether having a therapy dog nearby can lower pain and anxiety in children ages 3 to 10 who are having pins taken out of their elbow after a fracture. Fifty-two kids took part, and researchers measured their pain and worry using special scales. The goal was t…

This study tested a mindfulness-based diabetes education program for adults with type 2 diabetes who feel high stress about their condition. 36 participants from low-income clinics were randomly assigned to either the mindfulness program or standard diabetes education. The goal w…

This study looked at whether a 6-week exercise program could help improve memory in adults with idiopathic generalized epilepsy (IGE). 71 participants either exercised or did not, and researchers measured memory and brain changes. The goal was to see if exercise offers a drug-fre…

This early-phase study tested a new way to deliver nitric oxide—a molecule that relaxes blood vessels—by placing a mixture under the tongue. Fourteen healthy adults took part to see if this method safely lowers blood pressure. The goal is to find an alternative to current nitrate…

This study tested whether adding a special anti-inflammatory knee sleeve (Reparel™) to a standard corticosteroid injection improves pain, mobility, and daily function in people with knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were randomly assi…

This study tested a distance-learning program that trains family caregivers to reduce care-resistant behaviors in people with Alzheimer's dementia or traumatic brain injury. The program aimed to improve quality of life for both patients and their families. Researchers enrolled 88…

This study tested a 4-hour workshop based on acceptance and commitment therapy (ACT) to help women with obesity adopt and maintain healthy lifestyle behaviors. Fifty-two women participated, completing questionnaires and physical measurements before, one week after, and one month …

This small study tested whether active video gaming (like using a special balance board) could help adults with physical disabilities become more active and improve their physical function. Six participants tried the gaming program for 6 weeks. The goal was to see if this approac…

This study tested whether a 6-week home-based virtual reality exercise program is acceptable and beneficial for young people with cerebral palsy who are overweight and inactive. Four participants used a head-mounted display to play active games. Researchers measured changes in bo…

This study tested whether an 8-week home balance therapy program is practical for children aged 4-17 with inner ear problems causing dizziness. Twenty-one children did balance exercises at home 5 times a week, with weekly check-ins from a physical therapist. The goal was to see i…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury: one set to music and one standard routine. Participants were randomly assigned to either program or a control group. The goal was to see if these remote programs could increase physical act…

This study tested whether 20 hours of executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. 119 participants were split into a training group and a no-contact control group. The goal was to…

This study tested whether a noninvasive device that gently stimulates a nerve in the ear (taVNS) could help improve sleep in people with stage I-IV breast cancer. Twenty participants completed the trial, and researchers measured how practical and acceptable the treatment was. The…

This study tested a program called PRISM, designed to help women with breast cancer build resilience through skills like stress management, goal-setting, and positive thinking. 43 women participated, including those with early-stage or metastatic breast cancer. The goal was to se…

This study tracked 219 adults with severe COVID-19 who needed a ventilator to breathe. Researchers wanted to see how many also developed serious fungal infections, especially from a mold called Aspergillus. They used standard tests to check for these infections, but did not give …

This small pilot study looked at whether a short exercise program could improve thinking skills and blood vessel health in older adults (ages 55-75) with high blood pressure. Eleven participants completed a supervised exercise routine, and researchers measured changes in fitness,…

This study looked at a program where cancer patients report their symptoms from home using a computer or phone, with help from a navigator. Over 6,700 patients took part to see how well the program works and what makes it easier or harder to use. The goal was to learn how to impr…

This study looked at whether a computer-based decision-aid could help people with lupus and their doctors make better treatment choices together. Nearly 1,900 adults with lupus from several clinics took part. The main goal was to see how many eligible patients actually used the t…

This study tested whether a harmless bacterium called Oxalobacter formigenes can take up residence in the gut and reduce the amount of oxalate passed in urine. Oxalate is a key ingredient in many kidney stones. Researchers gave the bacterium to 26 healthy adults who did not alrea…

This study looked at whether a school program called MindUP, which teaches mindfulness, can improve mental health and focus in 5th to 8th graders. About 68 students from Alabama schools took part. Researchers measured changes in anxiety, attention, and stress to see if the progra…

This study looked at certain proteins in the blood of 75 adults with COVID-19 to see if they could predict how sick a person might get. Researchers measured levels of VEGF and sFlt-1, which are involved in blood vessel health. The goal was to find links between these markers and …

This study tested over 5,000 adults from Zambian households for hepatitis B virus (HBV) to find out how many people have been infected and how many need treatment. Researchers collected blood samples and health information to map the spread of HBV and related liver conditions. No…

This study looked at whether giving monthly reimbursements to women with breast cancer in a clinical trial could help with their financial stress. Researchers wanted to see if it was possible to run such a program and if it made a difference. Thirty-nine women from the Deep South…

This study looked at how the antibiotic amoxicillin behaves in the bodies of pregnant women. The goal was to find the right dose to prevent passing syphilis to the baby. Thirteen women in their second or third trimester took part. Researchers measured drug levels in their blood a…

This study looked at why low-income African American women often don't get enough physical activity. Researchers worked with 46 women living in public housing to understand the barriers they face. The goal was to use this information to create a fitness education program that fit…

This study looked at whether certain gene variations (vitamin D receptor polymorphisms) are linked to a higher risk of non-melanoma skin cancer. Researchers compared 200 people aged 50 and older, some with and some without skin cancer, to find any connections. The goal was to bet…

This study tested whether improving neighborhoods (like cleaning up blight) and offering family support programs can help mothers and their children ages 11-16 living in disadvantaged areas. About 915 people took part. Researchers measured things like child behavior, neighborhood…

This study looked at how the wording in MRI reports affects people with lower back pain. Sometimes, scary terms in reports can make patients feel worse or push them toward unnecessary treatments—this is called the nocebo effect. Researchers tested a new way of writing reports to …

This study looked at whether eating less salt before bed can improve blood pressure and body rhythms in people with obesity. Researchers measured blood pressure, body temperature, and sleep-related hormone changes in 53 adults. The goal was to learn how salt timing affects health…

This study tested a new AI-assisted telehealth program designed to help adults with physical disabilities manage chronic conditions like heart disease, lung disease, or type 2 diabetes. Over 200 participants used the platform from home to improve their quality of life. The goal w…

This study tested whether an 8-week SKY breath meditation program is practical and helpful for reducing stress and improving well-being in healthy adults. Researchers measured changes in stress, anxiety, and happiness using surveys, wearable devices, and blood tests. The goal was…

This completed study with 200 participants looked at how to improve shared decision-making for women with metastatic breast cancer. Researchers interviewed patients, nurses, and doctors to understand what matters most when choosing treatments, including the option to reduce chemo…

This study tested a training program for family medicine doctors in Alabama to help them talk about HIV and STI prevention with teenage girls and young women. 46 doctors completed surveys before and after training to see if the program was practical and well-liked. The goal was t…

This study tested a new rapid HIV test for infants and young children in Zambia to see if it helps more babies start treatment sooner. Researchers enrolled over 1,600 HIV-exposed children up to 17 months old. The goal was to measure how many infected infants began antiretroviral …

This study tested a new website designed to help people with physical disabilities find accessible exercise and recreation programs in their community. Seven adults aged 18 to 64 with mobility-limiting disabilities used the site and provided feedback through surveys and interview…

This study looked at whether video or phone visits with a rheumatologist work as well as in-person visits for people with rheumatic diseases like arthritis. Over 650 adults took part, and researchers measured how satisfied patients were with each type of visit and which they pref…

This study tested whether virtual reality (VR) training can help people with low vision learn important street-crossing skills. 117 participants were split into three groups: one trained with a VR system, one with a real instructor on actual streets, and one watched educational v…

This study looked at whether a community health worker program could help Black patients who had serious pregnancy complications like preeclampsia. The goal was to see if the program was acceptable and could improve blood pressure and long-term heart health. 61 participants were …

This study tested whether a program called ImPart-Multi, led by lay navigators, is practical and acceptable for Black patients with chronic kidney disease and their care partners. The program used education and telehealth sessions to help patients and their partners become more a…

This study involved 120 children and adults with sickle cell disease to develop a more accurate way to estimate kidney function. Current tests are not designed for sickle cell patients, so researchers are creating a new equation using biological markers. The goal is to improve ho…

This study looked at 200 patients having repeat surgery on the front of the neck spine. Researchers checked voice and swallowing with a camera exam before and about 3 weeks after surgery. They also asked patients about their quality of life. The goal was to learn how these functi…

This study looked at stem cells taken from two different parts of the roof of the mouth (front vs. back) to see which ones are better at growing bone and other dental tissues. Only 7 people took part, and the goal was to learn how these cells work, not to treat any disease. The f…

This study tested two approaches to improve pregnancy care for Black women: text message support and help from community health workers. 40 pregnant women participated to see if they would use these services and recommend them to others. The goal is to find simple, cost-effective…

This study gave a nasal flu vaccine to 33 healthy adults to mimic a mild flu infection. Researchers then collected nose samples to measure how the virus grows and how the immune system reacts. The goal was to create a safe way to study flu infections in people, not to test a new …

This study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Researchers measured pain sensitivity, sleep patterns, and blood markers. The goal is to confirm that treating insomnia could help reduce pain and inflammation in people livin…

This study tested new methods to measure and train eye movements in 21 people with macular degeneration and severe vision loss. Participants practiced using a different part of their retina to see, and researchers tracked changes in vision and eye movement over 14 weeks. The goal…

This study measured how much pressure different hospital bed mattresses put on the tailbone area of healthy volunteers. Researchers tested two bed systems with volunteers lying flat and with their head slightly raised. The goal was to gather data to help understand how mattress d…