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Sickle cell patients may get better kidney checks thanks to new study

NCT ID NCT04380610

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study worked to improve how doctors estimate kidney function in people with sickle cell disease. Researchers measured actual kidney function in 120 patients and used that data to develop a new formula tailored to sickle cell. The goal is to replace current equations that were designed for the general population and may be less accurate for sickle cell patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better monitoring of kidney health in sickle cell patients, helping doctors catch problems earlier.
What could go wrong
This is an observational study focused on improving measurements, not testing a new treatment. The new equation may not prove more accurate in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

120 people

The number who actually took part.

Started

May 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with sickle cell anemia

Ages

5 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * SCA patients (HbSS and SB0 thalassemia) * Age: 5.0-50.0 at enrollment Exclusion Criteria: * Recent SCA complication associated with hospitalization (within 30 days) or ED visit (within 14 days) * Current AKI defined as \>0.3mg/g increase in SCr from prior visit * Known history of anaphylaxis with contrast agent or known pregnancy

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Conditions

The condition(s) this trial relates to.

glomerular disorder kidney disorder sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glomerular disease Renal disease Sickle cell disease

Contacts and locations

Locations

  • St Jude Childrens Research Hospital

    Memphis, Tennessee, 38106, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35223, United States

  • University of Illinois Chicage

    Chicago, Illinois, 60612, United States

  • University of Tennessee Health Science Center

    Memphis, Tennessee, 38163, United States

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