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Gum stem cells could regrow teeth and bone

NCT ID NCT03570333

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability to turn into bone, cartilage, and ligament fibers. The goal is to learn how to best use these cells for future dental tissue regeneration.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gingival mesenchymal stem cells
What this could lead to
If successful, this research could point toward new ways to regenerate gum and bone tissue for dental repairs.
What could go wrong
This is a very small, early lab study with only 7 participants. It only tests cells in a dish, not in people, so it may not lead to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

7 people

The number who actually took part.

Started

Sep 2018

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * English speaking * Must be a patient of the UAB Dental School * Able to read and understand informed consent document * Patients needing soft tissue graft with teeth that have miller class I or II recession (\>=2mm) on the facial aspects * No previous harvesting procedure involving the palate * Presence of periodontally healthy teeth at the recipient site. * Ability of the participants to maintain good oral hygiene * Patient not pregnant or breastfeeding * Not taking medications known to cause gingival enlargement Exclusion Criteria: * Non-English speaking * Smokers/tobacco users * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Patients that have severe gingival recession (Miller class III and IV) or \< 2 mm. * Previous harvesting procedure involving the palate (within 1 year) * Presence of periodontal disease at the recipient site. * Poor oral hygiene * Patient pregnant or breastfeeding * Taking medications known to cause gingival enlargement

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Conditions

The condition(s) this trial relates to.

Bicuspid Aortic Valve Disease gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession Lack of keratinized gingiva (disorder)

Contacts and locations

Locations

  • UAB School of Dentistry Department of Periodontology

    Birmingham, Alabama, 35294-0007, United States

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