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Gum graft boost: growth factors may strengthen receding gum repair

NCT ID NCT07736833

Disease control Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether applying a liquid growth factor solution (LPCGF) to the tooth root during standard gum graft surgery can improve gum thickness and coverage. Twenty adults with receding gums will receive either the standard treatment or the standard treatment plus LPCGF. The goal is to see if the added growth factors lead to better healing and a stronger, healthier gum.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liquid-phase concentrated growth factors (LPCGF) applied to the tooth root during gum graft surgery
What this could lead to
If effective, this approach could improve gum thickness and coverage, leading to better long-term outcomes for people with receding gums.
What could go wrong
This is a small, early-stage trial with only 20 participants, so results may not apply broadly. Adding LPCGF may not provide significant benefit over standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 50 years old. * Patients with good systemic health with no contraindication for periodontal surgery. * No history of systemic or local medications within the previous six months that could affect periodontal tissue health or wound healing. * Recession depth ≥ 3 mm, measured from the cementoenamel junction (CEJ) to the gingival margin and/ or width of attached gingiva \< 3 mm. * Presence of identifiable cementoenamel junction (CEJ). * Absence of interproximal attachment loss (i.e., intact interdental bone and soft tissue, confirmed radiographically). * Ability to maintain adequate oral hygiene, as demonstrated during recall visits. Exclusion Criteria: * Restoration or caries in the site to be treated or non-vital tooth. * Previous mucogingival surgery at the defect. * Active infectious diseases (hepatitis, HIV, etc.). * Smokers and pregnant patients. * Teeth that are tilted rotated or have any non-alterable occlusal abnormalities. * Sites with tooth mobility.

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession

Contacts and locations

Locations

  • faculty of dentistry, Tanta university

    Tanta, Gharbia Governorate, 31773, Egypt

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Other studies related to the condition(s) this trial covers.