Tanta University

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This phase 3 trial will test how well two different triple therapies—one using a standard acid reducer (proton pump inhibitor) and one using a newer drug (vonoprazan)—work to eliminate H. pylori infection. It will also see if adding zinc improves results. The study plans to enrol…

This study tests a newer acid-blocking drug (vonoprazan) against a standard one, each combined with vitamin D or probiotics, to treat H. pylori infection. About 66 adults with confirmed H. pylori will receive one of three treatments for two weeks. The goal is to see which combina…

This trial compares two types of surgical guides used when placing dental implants immediately after extracting a front upper tooth. One is a conventional guide, and the other is a modified SocketFit guide designed to stay more stable after the tooth is removed. The study will me…

This phase 2 trial tests whether adding either diosmin or rebamipide to standard rheumatoid arthritis treatment can better reduce disease activity and improve physical function. About 66 adults with active rheumatoid arthritis will be split into three groups: one receiving standa…

This trial tests whether different 3D printing angles and layer thicknesses affect how accurately dentures fit and how satisfied patients are. Adults aged 50 to 70 with no teeth will each receive two 3D-printed upper dentures made with the same angle but different thicknesses, in…

This study compares two types of laparoscopic surgery (Nissen vs. Hill-Snow fundoplication) for children with severe acid reflux. The goal is to see which technique better preserves normal stomach emptying and reduces post-surgery problems like bloating or trouble swallowing. The…

This trial compares two methods for weaning patients off mechanical ventilators in the ICU. One method uses standard pressure support, while the other adjusts support based on a measure called airway occlusion pressure (P0.1). The goal is to see which approach leads to more days …

This trial tests whether febuxostat, a drug typically used for gout, can improve recovery in people with a brain bleed (intracranial hemorrhage) who are treated without surgery. Participants take febuxostat or standard care for three months. The study measures consciousness level…

This trial compares two microsurgical techniques—single versus double dartos flap—for repairing distal hypospadias in children. Researchers will measure which method leads to fewer complications like fistulas, meatal narrowing, or infections. The study includes 100 boys aged 6 mo…

This study tests whether nicorandil, a drug usually used for heart conditions, can reduce inflammation and improve symptoms in people with active rheumatoid arthritis. 46 participants will take nicorandil tablets for 3 months. Researchers will measure joint disease activity and p…

This study tests whether carbocisteine, a drug already used for coughs, can safely reduce fat buildup in the liver of people with nonalcoholic fatty liver disease (NAFLD). About 46 adults with fatty liver will take the drug and be monitored for changes in liver fat via ultrasound…

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 46 women with early-stage breast cancer who are about to start chemotherapy. Participa…

This study compares two methods to prevent ovarian hyperstimulation syndrome (OHSS), a serious side effect of fertility treatments. About 150 women at high risk for OHSS will receive either cabergoline or a standard 'coasting' procedure. The goal is to see which approach better r…

This study tests whether adding mebendazole, a common deworming medication, to standard mesalamine therapy can improve symptoms in people with mild-to-moderate ulcerative colitis. 46 adults will take mebendazole or a placebo twice daily for 6 months. Researchers will measure chan…

This study tests whether adding empagliflozin, a diabetes drug, can reduce weight gain and other metabolic side effects caused by olanzapine in people with schizophrenia. Forty adults aged 18 to 60 who take olanzapine will receive either empagliflozin or a placebo for several wee…

This study looks at whether treating children with a mild form of underactive thyroid (subclinical hypothyroidism) using a medication called levothyroxine can improve how well their hearts pump blood. The researchers will measure heart function in 40 children aged 4 to 15 before …

This study is testing whether adding the allergy medicine desloratadine to standard ulcerative colitis treatment can better control inflammation and symptoms. About 44 adults with mild to moderate ulcerative colitis will take either desloratadine plus mesalamine or mesalamine alo…

This study tests whether vinpocetine, a drug thought to improve blood flow in the brain, can safely reduce Parkinson's symptoms like tremor and stiffness. Researchers will enroll 60 adults with Parkinson's who already take levodopa. The goal is to see if adding vinpocetine leads …

This study tests whether erdosteine, a drug usually used for lung conditions, can help people with nonalcoholic fatty liver disease. Fifty adults with fatty liver will receive either standard care (diet and exercise) or standard care plus erdosteine. Researchers will measure chan…

This early-stage trial tests whether cilostazol, a drug used for leg pain, can help people with nonalcoholic fatty liver disease (NAFLD). About 50 adults with fatty liver will take the drug to see if it reduces liver fat and lowers fibrosis risk scores. The study aims to find a n…

This study tests whether metformin, a standard diabetes medication, can safely improve movement and quality of life in people with Parkinson's disease. Researchers will enroll 60 adults aged 50 and older who are already taking levodopa/carbidopa. The main goal is to see if metfor…

This study compares two types of acid-reducing drugs—vonoprazan (a newer drug) and rabeprazole (a standard drug)—when used as part of a 10-day combination therapy for H. pylori infection. About 320 adults with confirmed H. pylori will be randomly assigned to one of the two treatm…

This Phase 2 trial is testing whether silymarin, an antioxidant from milk thistle, can protect brain cells and improve symptoms in people with Parkinson's disease. Researchers will give 50 adults either silymarin or a placebo alongside their usual Parkinson's medications. The goa…

This Phase 2 trial tests whether adding pentoxifylline (a drug usually used for blood flow) to standard methotrexate therapy can reduce inflammation in people with active rheumatoid arthritis. Fifty adults aged 18–70 with moderate-to-severe disease will receive the combination fo…

This study compares two surgical techniques for treating a narrowed urethra in women: using a graft from the mouth or from the labia. Forty women with non-traumatic urethral stricture will be randomly assigned to one of the two procedures. The main goal is to see which graft lead…

Preterm babies face a serious risk of late-onset sepsis, an infection that can be hard to diagnose quickly. This study checks whether monocyte distribution width, a measurement taken from a standard blood count, can accurately identify which preterm babies have the infection. Res…

This study compares muscle thickness around the shoulder blade in people with early ankylosing spondylitis (an inflammatory condition) versus those with mechanical shoulder blade movement problems. Researchers use ultrasound and electromyography (EMG) to see if they can tell the …

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study looks at two substances in the blood—endocan and copeptin—in 40 premature babies born between 28 and 36 weeks who have breathing trouble (respiratory distress syndrome). Researchers will measure these markers on the first day of life to see if they can predict how seve…

This phase 3 trial tests whether the nerve pain medication duloxetine can prevent pancreatitis, a serious complication that sometimes occurs after an ERCP procedure. Researchers will give duloxetine or a placebo to 44 adults with biliary disease before their ERCP. The main goal i…

This study tests whether giving a single IV dose of lidocaine before a C-section can prevent headaches caused when doctors press on the belly to deliver the baby. About 680 women having planned C-sections under spinal anesthesia will be randomly assigned to receive lidocaine or a…

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

This study tests whether an ondansetron lozenge works as well as an IV injection to prevent shivering in women having a cesarean section. About 90 women will receive either the lozenge or the IV before surgery. The goal is to find a simpler, more comfortable way to reduce shiveri…

This study tests whether an ondansetron lozenge works as well as an IV to prevent shivering in children aged 4 to 15 having their tonsils removed. Shivering is a common side effect after anesthesia. The trial will enroll 210 children and also check for nausea, vomiting, and tempe…

This study tests whether ondansetron, a drug often used for nausea, can prevent pancreatitis (inflammation of the pancreas) after a procedure called ERCP. About 44 adults who need this procedure will receive ondansetron or a placebo. The main goal is to see if fewer people develo…

Carpal tunnel syndrome happens when the median nerve gets squeezed at the wrist, causing numbness, tingling, and pain in the hand. This study compares three ultrasound-guided injections for adults with mild to moderate cases: hyaluronic acid, corticosteroid, and 5% glucose. Sixty…

Researchers compare two ultrasound-guided nerve blocks to see which controls pain better after total hip replacement. Adults scheduled for hip replacement under spinal anesthesia receive either a Quadroiliac Plane Block or a transmuscular Quadratus Lumborum Block, both using the …

This trial tests whether taking a single oral dose of tizanidine, a muscle relaxant, before lower limb orthopedic surgery can reduce postoperative pain and improve sleep quality. Researchers will compare tizanidine against a placebo in 68 adults scheduled for surgery. They will m…

This trial compares two ultrasound-guided nerve blocks for pain relief after total hip replacement surgery. Researchers will measure pain levels, opioid use, and recovery quality in 80 adults undergoing the procedure. The goal is to see which block provides better pain control wh…

This trial tests whether using two probes during radiofrequency ablation eases knee osteoarthritis pain better than the standard one-probe approach. Radiofrequency ablation uses heat to quiet the nerves that send pain signals from the knee. Researchers will enroll 64 adults over …

This trial tests whether a single injection of morphine or dexmedetomidine into the spinal fluid, given at the end of spine fixation surgery, can provide better pain relief than a placebo. Adults aged 21 to 60 scheduled for elective lumbar spine surgery will be randomly assigned …

This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression score…

This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participan…

This study compares two types of nerve blocks given before breast cancer surgery (modified radical mastectomy) to see which one helps patients recover better. Sixty women will receive either a newer block called subtransverse interligamentary plane block or the standard thoracic …

This trial compares two ultrasound-guided nerve blocks — the midpoint transverse process to pleura (MTP) block and the erector spinae plane (ESP) block — for treating acute pain from shingles (herpes zoster) on the chest. About 90 adults with moderate to severe pain will receive …

This study tests whether giving magnesium before surgery can reduce emergence delirium—a state of confusion and agitation—in children aged 4 to 7 after adenotonsillectomy. Half the children receive magnesium by mouth before surgery, half receive it through an IV during surgery, a…

This study tests whether adding methylene blue to a standard numbing medicine (bupivacaine) delivered through a nerve catheter can reduce pain after lower leg amputation and prevent chronic phantom limb pain. About 72 adults scheduled for above- or below-knee amputation will rece…

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether injecting Botox or hyaluronic acid into the knee joint can reduce pain in people with knee osteoarthritis. Fifty adults aged 50 and older with moderate to severe knee arthritis will receive three weekly injections of one of the two treatments. The main go…

This study tests two different ultrasound-guided nerve blocks to see which provides better pain relief for children aged 6 to 12 after chest surgery. Seventy-five children will receive either a subtransverse process interligamentary plane block or a rhomboid intercostal block com…

This study compares two types of nerve blocks—Quadro-Iliac Plane Block and Erector Spinae Plane Block—for pain relief after total hip replacement. About 76 adults undergoing hip surgery will receive one of the two blocks. Researchers will measure how long pain relief lasts and ho…

This trial tests whether a short, temporary nerve stimulation can reduce pain in people with moderate to severe knee osteoarthritis. About 100 adults aged 30 to 70 who have not found relief from oral pain medications or physical therapy will receive a brief electrical pulse to sp…

This study tests whether adding shock wave therapy to standard physical rehabilitation helps people with scapular dyskinesis, a condition where the shoulder blade moves abnormally. About 100 adults who have had symptoms for at least six months will be split into two groups: one g…

This study compares three different surgical techniques for men with very large prostates (over 100 mL) who have severe urinary symptoms. Ninety men will be randomly assigned to receive either thulium fiber laser, holmium laser, or bipolar electrosurgery. Researchers will measure…

This trial tests if using ultrasound to guide a nerve root injection works as well as the standard X-ray method for treating lower back and leg pain from irritated nerves. Sixty-four adults aged 18 to 75 will receive one injection of steroid and numbing medicine, then be followed…

This study tests three pelvic floor treatments in 150 men with lifelong premature ejaculation: electromagnetic stimulation, biofeedback training, and standard exercises. The goal is to see which best increases ejaculation time and improves control. Participants will be treated fo…

This study tests whether combining two types of nerve blocks (superior hypogastric plexus block and transversus abdominis plane block) can better control pain after abdominal hysterectomy. About 44 adults undergoing this surgery will receive either the combo block or standard car…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study looks at whether giving the anti-nausea drug ondansetron near the nerves in the belly works as well as giving it through a vein to control pain and vomiting after laparoscopic sleeve gastrectomy. About 482 adults having this weight-loss surgery will take part. The goal…

This phase 3 trial tests whether adding roflumilast (a COPD drug) to the antidepressant fluoxetine helps people with major depression who haven't responded well to treatment. Sixty adults with moderate-to-severe depression will take either the combination or a placebo for 8 weeks…

This study tests whether injecting botulinum toxin-A (like Botox) into the bladder can help children with certain bladder problems that haven't improved with standard treatments. It includes children under 18 with either dysfunctional voiding (trouble peeing normally) or nighttim…

This study compares three medications—theophylline, sumatriptan, and gabapentin—to see which works best for post-dural puncture headache, a severe headache that can occur after a spinal tap or epidural. Researchers will enroll 75 adults aged 21 to 50 who have this type of headach…

This study tests three different drugs—empagliflozin, acetazolamide, and metolazone—added to standard water pills (loop diuretics) in 66 adults hospitalized for acute decompensated heart failure. The goal is to see which drug works best at increasing urine output over three days.…

This study is testing whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already on standard treatment. Researchers will enroll 46 adults aged 50 and older with mild to moderate Parkinson's. The main goal is …

This study tests whether melatonin (a natural sleep hormone) works as well as pregabalin (a nerve pain drug) for managing pain and anxiety after spine surgery. About 105 adults aged 21-60 having elective spine surgery will receive one of the two medicines right after surgery. Res…

This study tests whether giving children oral melatonin or a nebulized drug called dexmedetomidine before surgery can reduce confusion and agitation when they wake up after adenotonsillectomy. About 96 children aged 3 to 7 will be randomly assigned to one of three groups: melaton…

This study compares three different ways to clean the bowel before a colonoscopy to see which is safest, easiest, and works best. About 450 adults will be randomly assigned to one of three preparation methods. Researchers will measure how clean the bowel gets, any side effects, a…

This study is testing whether a special nerve block, called EXORA, can reduce the body's stress response and pain during umbilical hernia surgery. One hundred adults will be randomly assigned to receive either general anesthesia alone or general anesthesia plus the EXORA block. R…

This study compares two ways to manage pain after scoliosis surgery: a nerve block called MTP (injected near the spine) versus patient-controlled morphine (PCA). Forty adults with idiopathic scoliosis will be randomly assigned to one of the two methods. The main goal is to see wh…

This study tests whether celecoxib, an anti-inflammatory drug, can help people with Parkinson's disease. Researchers believe brain inflammation plays a role in Parkinson's, and celecoxib may reduce that inflammation. The trial will include 80 adults with Parkinson's and measure c…

This study tests whether dapagliflozin, a drug normally used for diabetes, can help reduce depression symptoms when added to standard antidepressant treatment. Sixty adults with moderate to severe depression will receive either dapagliflozin plus fluoxetine or fluoxetine alone. T…

This study tests whether fenofibrate, a drug typically used for high cholesterol, can prevent or reduce nerve damage caused by a common chemotherapy regimen for multiple myeloma. The trial will enroll 44 newly diagnosed patients, half receiving fenofibrate alongside their standar…

This study compares two ways to manage pain after a C-section: a nerve block (TFP block) and a medication added to spinal anesthesia (intrathecal dexmedetomidine). Fifty women undergoing planned C-sections will be randomly assigned to one of the two methods. Researchers will meas…

This study tests whether giving dexmedetomidine 20 minutes before anesthesia, instead of 10 minutes, better controls stress responses like high blood pressure and heart rate during breathing tube insertion. 45 adults undergoing surgery will be randomly assigned to one of three ti…

This study compares two types of nerve blocks—sacral erector spinae plane block and caudal block—to see which provides better pain relief after hypospadias repair in boys aged 1 to 5. Seventy children will receive one of the two blocks along with standard care. Researchers will m…

Many young children with extensive tooth decay or special health needs receive full-mouth dental repair under general anesthesia. Dentists use a mix of fillings, crowns, and other materials, but little is known about how well each option holds up over time. This study follows 180…

This study investigates whether an ultrasound measurement of the internal jugular vein in the neck can help assess fluid status in pregnant women with preeclampsia, compared to those with normal blood pressure. Researchers will measure the vein's collapsibility index before cesar…

This study tests three different ways of taking digital impressions for lower jaw implant-supported dentures in people with no natural teeth. Each participant gets scanned with all three methods to see which one gives the most accurate implant positions and best fit. The goal is …

This study looks at why people with rheumatoid arthritis (RA) may have trouble swallowing. Researchers will use a small, flexible camera to examine the throat and voice box in 137 adults with RA. They aim to find factors that predict swallowing difficulty and see if joint problem…

This study tests a dental procedure called Deep Marginal Elevation (DME) in 36 adults with deep cavities. DME uses a special cement to raise the cavity margin, making it easier to clean and restore. Researchers will check gum fluid and X-rays to see if the procedure affects gum i…