University Of Alabama At Birmingham

This study tests personalized diet and exercise plans to help adults aged 50-75 with obesity lose weight while keeping muscle. Participants will follow different protein and exercise routines over 52 weeks. The goal is to find the best approach for healthy weight loss in older ad…

This study offers a free 3-month diabetes education program at a local faith center for adults in Jefferson County, Alabama. Participants learn about diet, exercise, and medication, and get support from a community health worker. Some will use a remote monitoring system to track …

This study tests whether a ketogenic (low-carb, high-fat) diet helps older adults (55+) with pneumonia maintain muscle function better than a standard hospital diet. Thirty participants will be randomly assigned to one of the two diets during their hospital stay. The main goals a…

This study tests a combination of three drugs (selumetinib, ZEN-3694, and durvalumab) in people with advanced sarcomas, including a type called MPNST. The goal is to see if the combination is safe and can shrink tumors or stop them from growing. About 41 adults with sarcomas that…

This study tests whether giving extremely premature babies (born at 28 weeks or earlier) a special diet enriched with DHA and ARA during their first two weeks of life can reduce lung damage and improve breathing. About 150 babies will be randomly assigned to receive either the en…

This study tests if a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin for treating congenital syphilis in newborns up to 30 days old. About 374 infants will be enrolled at 12 U.S. sites. The goal is to find a treatment that is easier to giv…

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. About 64 adults who lost at least 15% of their body weight on these drugs will be randomly assigned to extra support like tailored meals, gym …

This study tests a drug called mirdametinib, which targets a specific genetic change (NF1 alteration) found in some aggressive brain tumors. It will enroll 55 people with either NF1-related or sporadic high-grade glioma. Some participants will receive the drug alone, while others…

This study will test a program that combines peer support with remote patient monitoring to help Black adults with uncontrolled type 2 diabetes. Researchers will enroll 200 participants from primary care clinics in Alabama and track changes in blood sugar (A1C) and blood pressure…

This study compares two surgical techniques for repairing a torn anterior cruciate ligament (ACL) in the knee. Sixty adults with an ACL-deficient knee will be randomly assigned to receive either a standard reconstruction using their own tissue or a donor tissue reconstruction wit…

This study compares two telehealth programs—digital health coaching and remote patient monitoring—to see which better helps people with physical disabilities manage type 2 diabetes and other chronic conditions. About 5,000 participants will be followed for 12 months to measure ch…

This study tests whether using a home blood pressure monitor and video doctor visits can help people living in rural areas better manage their heart failure. Researchers will enroll 32 adults with heart failure to see if this approach is practical and acceptable. The goal is to i…

This study looks at whether adding the Nutu™ digital health platform to standard obesity treatment helps people lose more weight. About 300 adults in a primary care program will be offered the app, and researchers will track weight changes and how often people use it. The goal is…

This study tests whether a combination of a bile acid supplement and a traditional Chinese medicine formula can help people with diabetic macular edema, a vision problem from diabetes. The treatment aims to reduce inflammation and stress in the liver and eyes. About 69 adults wit…

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study tests whether a new cleaning technology (GentleWave) is better than standard methods for disinfecting root canals in molars that still have infection after initial treatment. About 60 adults with persistent infection will be randomly assigned to receive either the new …

This study tests a program for people with opioid use disorder who have had an overdose. After leaving the emergency room, participants get telehealth visits, a peer support specialist, and medication (buprenorphine) to help them stay in treatment. The goal is to reduce repeat ov…

This early-stage study tests a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. Researchers will study healthy volunteers and people with recurrent high-grade glioma or brain metastases from other cancers. The…

This study tests whether mailing fentanyl test strips and providing education can reduce overdose deaths in adults who use opioids or stimulants. Researchers will compare different combinations of test strips and education to find the most effective and cost-saving approach. The …

This study tests whether training young people to deliver HIV prevention medication (PrEP) to their peers increases its use. About 1,400 sexually active youth aged 15-24 in Brazil who are not currently taking PrEP will be randomly assigned to either peer-led community-based PrEP …

This study tests whether giving caffeine citrate to moderately preterm babies after they leave the hospital can prevent breathing pauses (apnea) that lead to sick visits. About 340 infants will receive either caffeine or a placebo daily for up to 28 days. Researchers will track a…

This study tests a quick, tablet-based Digital PrEP Toolkit designed to help cisgender women in Alabama and Mississippi learn about PrEP, a daily pill that prevents HIV. About 125 women at three clinics will use the toolkit and answer questions about their HIV knowledge. Research…

This study tests whether placing a soft tissue matrix over a nerve in the arm during reconstructive surgery can prevent nerve pain and numbness. About 80 head and neck cancer patients having a radial forearm free flap will be randomly assigned to receive the matrix or standard cl…

This study tests whether adding folic acid to iodized salt can raise folate levels in women of childbearing age in Zambia, where food is not fortified with folic acid. About 250 non-pregnant women aged 18-45 will use the special salt for 6 months instead of their regular salt. Re…

This study tests whether Pycnogenol, a natural extract from French maritime pine bark, can reduce symptoms of Gulf War Illness (GWI) like fatigue, pain, and brain fog. Researchers think GWI involves inflammation, and this botanical may help. Twenty male veterans who meet GWI crit…

This early-stage study tests a drug called octreotide, given as a nose spray, for people with diabetic macular edema (swelling in the back of the eye) that hasn't improved with standard treatments. The goal is to see if the spray is safe and can reduce swelling and improve vision…

This study tests a prescription eye drop called Vevye (cyclosporine 0.1%) in 48 adults with meibomian gland dysfunction, a common cause of dry, irritated eyes. Participants use the drops twice daily for 24 weeks. Researchers will check if symptoms like dryness and eye surface hea…

This study looks at whether a flaxseed supplement (rich in omega-3) can improve pain and gut health in children with sickle cell disease. About 20 children aged 5–18 will eat flaxseed daily for several weeks. Researchers will track how easy it is to stick with the supplement and …

This study tests whether low-dose naltrexone (LDN) can reduce fatigue in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). It involves 75 adults living in Alabama who will take LDN and report their fatigue levels weekly. The goal is to find the best dose fo…

This study tests whether a brief mobile app can help improve mood and reduce negative thinking in 100 people with schizophrenia or at clinical high risk for psychosis. Participants will use the app and report changes in defeatist beliefs and negative symptoms. The goal is to see …

This study tests whether a 12-week online program can improve motivation and goal-setting in people with schizophrenia or early psychosis. Each week, participants complete a 20-30 minute session focused on boosting mood and positive feelings. The goal is to see if this approach h…

This study will test a process-based approach (PBA) to help 10 adults with anxiety. Participants must have high anxiety scores and a mobile device. The study will measure changes in anxiety, depression, and quality of life over time.

This study tests a remotely delivered program that combines mindfulness training with diabetes education for rural Black adults who have type 2 diabetes and high stress about their condition. Participants will either get this program plus remote blood sugar monitoring or standard…

This study tests a device called TearCare that warms the eyelids and helps unclog oil glands in young adults (ages 18-29) with dry eye disease. 45 participants will receive one treatment and be checked after 4 weeks to see if symptoms and tear film stability improve. The goal is …

This pilot study will test whether a high-fat, low-carbohydrate (ketogenic) diet can help reduce symptoms of bipolar disorder in 100 adults living in rural Alabama. Participants will continue their usual treatments while adding the diet. The goal is to see if this affordable, foo…

This study looks at whether a special gum surgery, called PAOO, can help move molars (back teeth) faster and with less pain during orthodontic treatment. About 40 adults will be randomly assigned to get braces alone or braces plus the surgery. The main goal is to see how much the…

This study tests a small ear device that gently stimulates a nerve to see if it is safe and comfortable for people who recently had a spinal cord injury. Researchers want to know if adding this stimulation before walking therapy can help improve mobility. The study involves 50 ad…

This study tests two ways of giving botox injections to treat voice tremor, a condition that causes a shaky voice. About 30 adults will get either a new injection into the false vocal folds or the standard muscle-guided injection. The goal is to see which method better improves v…

This study looks at whether an internet-based physical activity program can improve sexual dysfunction in women with relapsing-remitting multiple sclerosis. About 30 women who are in a committed relationship and have sexual problems will take part. They will wear a pedometer and …

This study will test two different times to add gum tissue around dental implants using a special skin graft material. About 40 adults who need a single implant and have thin gums will take part. The goal is to see which timing gives better gum thickness, width, and patient comfo…

This study compares two treatments for a painful tooth condition called irreversible pulpitis: a pulpotomy (removing only the infected part of the nerve) versus a root canal (removing the entire nerve). Researchers will track which treatment works better and look for signs that p…

This study tests whether virtual reality exercise games, done at home with telehealth coaching, can help inactive children with cerebral palsy (ages 10-17) become more active and improve their health. 130 participants will either play the games for 12 weeks or continue their usua…

This study compares two brain training programs for adults with long-lasting brain fog after a viral illness, including ME/CFS or post-COVID. Thirty participants will do about 30 hours of online training over 2-4 weeks, plus three in-person visits for blood tests and brain scans.…

This study looks at how spending time in a park affects emotional well-being in adults with mobility impairments who use manual wheelchairs. Over 10 weeks, participants will try two activities: 5 weeks of relaxing and enjoying nature while mostly sitting, and 5 weeks of wheeling …

This study tests whether a breath-based group program (Breath-Body-Mind) can help young breast cancer survivors (ages 18-50) feel less distressed. Thirty participants will be randomly assigned to either the breathing program or a standard education group. The goal is to see if th…

This study tests a new app that predicts when preterm infants will have pauses in breathing (apnea) and slow heart rate (bradycardia). The app will then trigger gentle stimulation to prevent these episodes. The study will enroll 25 preterm infants born before 32 weeks who have al…

This study looks at how your genes influence heart hormones called natriuretic peptides, which help control blood pressure and metabolism. Researchers will test 200 adults with mild high blood pressure to see how their genes affect their body's response to salt. The goal is to le…

This pilot study will test two different eye training methods in 20 people who have vision loss on one side (hemianopia) due to a stroke. One group will use an eye-tracking machine in the clinic, while the other will do reading exercises at home. The goal is to see which approach…

This study looks at whether the time you eat each day can affect brain health in people with multiple sclerosis. Researchers will ask 22 adults with MS to eat only during certain hours and track their meals using a smartphone. They will measure markers of nerve health and inflamm…

This study focuses on helping people with low health literacy recover better after colorectal surgery. Researchers will test a program called VISACT, which uses visual aids and coach training to improve recovery steps. About 1,050 patients and providers will take part. The goal i…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will choose to use an injectable contraceptive, an implant, or no hormonal birt…

This study will test two different surgical guide methods for placing dental implants to see which one is more accurate and leads to better healing. About 40 adults who need a single dental implant will take part. Researchers will measure how well the implant matches the plan, bo…

This study looks at why some people have more pain after colorectal surgery than others. Researchers will test pain sensitivity before surgery, check blood for inflammation markers, and ask about emotional health and life stress. The goal is to find better ways to manage pain for…

This study watches how well the brain controls its blood flow in people who had a type of stroke called subarachnoid hemorrhage. Researchers will use special sensors to monitor 120 patients in the ICU. The goal is to learn if changes in blood flow regulation can predict later bra…

This study looks at whether a medication called ETI (a CFTR modulator) helps control blood sugar in people with cystic fibrosis-related diabetes (CFRD). Researchers will compare 30 adults who can take ETI with those who cannot due to their genetic mutation. The goal is to underst…

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived scaffold (E-PRF) and releases over time. It compares this to the standard sponge carrier. The goal is to understand the release pattern, not to …

This early-stage study explores whether two different smell-based activities can improve smell and thinking in middle-aged and older adults with HIV. Eighty participants will either smell four scents twice daily or use a scent diffuser at night for 8 weeks. The main goal is to se…

This study looks at why some women have lasting pain after mastectomy. Researchers will test pain sensitivity, blood markers, and emotional health in 86 women before and after surgery. The goal is to find better ways to predict and manage pain during recovery.

This study tests whether a robot can measure brain blood flow in 20 patients recovering from spinal surgery in the intensive care unit. The goal is to create personalized blood pressure targets to protect the brain. The robot uses sound waves to track blood flow and may help doct…

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors in Ghana spot when a child's condition is getting worse faster than the usual method of checking vital signs by hand. About 250 children with inju…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…

This study looks at whether a special ultrasound technique called VExUS can help doctors manage fluids better in ICU patients with acute kidney injury. About 100 adults in intensive care will be observed and some will have their treatment guided by VExUS. The goal is to see if th…