Gum graft timing may improve dental implant success
NCT ID NCT07512245
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two different times to perform gum grafting using a special skin substitute (acellular dermis) around dental implants. Forty adults with a single missing tooth will receive the graft either at implant placement or at a later uncovering step. Researchers will measure gum thickness, width, and bone levels, as well as patient comfort, to see which timing works better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- acellular dermis
- What this could lead to
- If successful, this could help dentists choose the best time to perform gum grafting around dental implants, improving gum thickness and health.
- What could go wrong
- This is a small, early-stage study with only 40 participants, so results may not apply to everyone. The procedure carries typical risks like pain, swelling, or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * English speaking * At least 18 years old * Must be a patient of the UAB Dental School * Able to read and understand informed consent document * Patients presenting with a single edentulous site planned for dental implant placement deemed deficient in soft tissue peri-implant phenotype (\> 2mm width of keratinized tissue, \< 1mm marginal soft tissue thickness, and/or \> 2mm vertical soft tissue height) * Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of edentulous site planned for dental implant placement. * No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period. Exclusion Criteria: * Non-English speaking * Less than 18 years old * Smokers/tobacco users (\>10 cigarettes/day) * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Edentulous sites treatment planned for dental implant placement with adequate implant site soft tissue quality/quantity (\> 2mm width of keratinized tissue, \> 1mm marginal soft tissue thickness, and/or \> 2mm vertical soft tissue height). * Absence of adjacent teeth/implants on either side of the tooth to be extracted and/or edentulous sites where 2 or more adjacent implants are planned.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294-0007, United States
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