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Could pine bark ease gulf war symptoms? small trial aims to find out

NCT ID NCT07266571

Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether Pycnogenol, a supplement from French maritime pine bark, can reduce symptoms of Gulf War Illness like fatigue, pain, and brain fog. Twenty male veterans who have already been in a related study will take either Pycnogenol or a placebo for up to 12 months. The goal is to see if it improves physical and mental functioning and to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pycnogenol (French maritime pine bark extract)
What this could lead to
If it works, this could point toward a natural supplement to reduce inflammation and improve daily functioning for veterans with Gulf War Illness.
What could go wrong
This is a very small, early-stage trial with only 20 male veterans, so results may not apply to everyone. As a dietary supplement, it is not FDA-approved as a drug, and its effects may be modest or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet the Kansas GWI case definition * Meet the CDC GWI case definition * Able to commit to a 12-month study * Male * Participants will be individuals in our Gulf War database who have already completed our other botanical trial, Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness (NCT05377242). Exclusion Criteria: * Currently involved in another experimental treatment study * Female * Have a blood clotting disorder * Reported diagnosis of diabetes with a A1C greater than 9 * Use of contraindicated medications (see below): * Anticoagulants (such as warfarin, heparin, etc.) * Lithium * Tacrolimus (Prograf) * Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen) * Daily Use of Antiplatelet agents (e.g. aspirin, clopidogrel) * Nitroglycerin * Hypotension * Need for surgery during study period.

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Conditions

The condition(s) this trial relates to.

persian gulf syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gulf war syndrome

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35243, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.