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Could a tiny brain zapper ease gulf war Veterans' pain?
NCT ID NCT07151248
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a non-invasive device that delivers a mild electrical current to the head (cranial electrical stimulation) can reduce pain and other symptoms in veterans with Gulf War Illness. About 130 participants aged 40-80 will receive either real or sham stimulation, and researchers will use brain scans to understand how it works. The goal is to find a safe, drug-free way to manage this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cranial electrical stimulation (CES) using Alpha-Stim™ device
- What this could lead to
- If it works, this could offer a drug-free, portable option for managing chronic pain and related symptoms in Gulf War Illness.
- What could go wrong
- This is an early-stage study with no phase designation, so results are uncertain. The sham control may also provide some sensation, potentially reducing the observed benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 130 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Sep 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects must be male and female age 40-80 years old 2. Meet criteria for GWVI based on the CDC and Kansas Criteria for GWVI. * CDC: 1 or more from at least 2 of the following categories for ≥ 6 months): 1) fatigue 2) mood and cognition (symptoms of feeling depressed, difficulty in remembering or concentrating, feeling moody, feeling anxious, trouble in finding words, or difficulty in sleeping) 3) musculoskeletal (symptoms of joint pain, joint stiffness, or muscle pain * Kansas: 3 of 6 domains: 1) fatigue and sleep problems 2) pain symptoms 3) neurologic, cognitive, or mood symptoms 4) gastrointestinal symptoms 5) respiratory symptoms 6) skin symptoms chronic since 1990. Symptom reporting must be in the absence of diagnosed exclusionary conditions; only respondents who have at least 1 moderately severe symptom or 2 or more symptoms within a group were considered to have a high level of symptoms in the group. 3. Subjects must self-report consistent, daily pain (greater than or equal to 4 on the DVPRS) \>90 days (prior to enrollment) 4. Subjects must have intact skin free of infection at the site of electrode placement (earlobe). 5. Subjects must be willing to participate and understand the consent. 6. Subjects must be right-handed to provide consistency in brain structure and function. Exclusion Criteria: 1. Subjects must not be currently pregnant since effects of fMRI and electrical current on the developing fetus are not well-known. 2. Subjects must not have a history of drug abuse or severe, uncontrolled psychiatric illness such as schizophrenia or major depressive disorder with suicidal ideation. 3. Subjects must not have psoriasis vulgaris or other skin conditions that may increase the risk of infection at the implantation site. 4. Subjects must not introduce new medications or treatments for symptoms during the study to prevent confounding results. 5. Subjects must not have severe anxiety, claustrophobia, or other conditions that may prevent their ability to lie at rest in an MRI scanner. This will be determined after discussion with the patient regarding their own perceived ability to lie at rest in an MRI scanner without the use of additional sedating medications. 6. Subjects must not have an implanted electrical device such as a surgically placed vagal stimulator, pacemaker, or spinal pain pump, which are not compatible with MRI. 7. Subjects must not have a history of seizures or neurologic conditions that may alter the structure of the brain. 8. Subjects must not be allergic to the metals used in electrodes for CES stimulation. 9. Subjects must not have a diagnosed autoimmune disease that better explains pain symptoms.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Emory Clinic
RECRUITINGAtlanta, Georgia, 30307, United States
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