Emory University

This study looks at whether a single booster dose of a meningitis B vaccine can protect young adults who got a different meningitis B vaccine at least 2.5 years ago. Researchers will measure immune responses in 125 healthy participants before and after the booster. The goal is to…

This early-stage study tests a personalized vaccine made from a patient's own tumor, combined with immunotherapy drugs, for triple negative breast cancer. The goal is to see if the vaccine is safe and can help the immune system attack cancer cells. About 18 adults with various st…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. Standard care includes ICU monitoring and blood pressure control. The study will enroll 600 adults aged 18-70 with a specific type of br…

This early-phase study tests a new drug called tegavivint combined with the chemotherapy gemcitabine in people whose osteosarcoma (a type of bone cancer) has returned or not responded to standard treatments. The main goal is to find the safest dose of tegavivint when given with g…

This study tests whether a combination of three drugs—belantamab, pomalidomide, and dexamethasone—can keep high-risk multiple myeloma from returning after a stem cell transplant. About 34 adults who have already had a transplant and are in partial remission or better will take th…

This study tests whether adding celecoxib (a painkiller) to standard immunotherapy drugs (durvalumab and tremelimumab) can help control advanced liver cancer that has spread. About 39 adults with advanced or metastatic hepatocellular carcinoma will receive the combination. The go…

This study tests whether atovaquone, a drug normally used for infections, can help people with a type of ovarian cancer that no longer responds to standard platinum chemotherapy. About 28 adults with platinum-resistant high-grade serous ovarian cancer will take atovaquone. The go…

This study looks at whether a low, personalized dose of aPCC (FEIBA) is safe and helps control bleeding in children and adults with hemophilia A who have inhibitors and are already taking emicizumab. Researchers will measure how well the blood clots after the dose and watch for s…

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if a gentle nerve stimulation device can boost the benefits. The study involves 150 adults with moderate CKD and measures changes in nerve acti…

This study tests whether simple digital checklists and reminders can help doctors prescribe the best combination of heart failure medications to more patients. Researchers will enroll 4,000 adults with heart failure and a weak heart pump. The goal is to see if these tools increas…

This study tests whether proton beam radiation, a precise type of radiation that spares healthy tissue, can reduce the risk of cancer returning in people with non-small cell lung cancer that has spread to chest lymph nodes. Participants have already had surgery and chemotherapy. …

This study tests whether adding a common cholesterol-lowering drug (lovastatin) to an immunotherapy (pembrolizumab) can help shrink tumors in people with head and neck cancer that has returned or spread. About 28 adults whose cancer has not responded to prior treatments will rece…

This study tests whether a microbiome therapy (like a fecal transplant) can safely reduce antibiotic-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to lower the amo…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has not responded to standard therapy or has returned. The approach combines specially grown immune cells (gamma delta T cells) from a healthy donor with several chemotherapy drugs and a…

This study aims to make opioid use disorder treatment more available in rural Georgia by connecting emergency room patients with medical toxicologists at the Georgia Poison Center through video calls. About 480 adults who come to the ER with opioid withdrawal, overdose, or seekin…

This study tests a precise type of radiation called proton therapy for men with high-risk prostate cancer that has spread to lymph nodes. The goal is to see if targeting the tumor and nearby lymph nodes causes fewer bowel and bladder side effects than standard radiation. About 30…

This early-phase study tests whether adding low-dose IL-2 to the immunotherapy drug pembrolizumab can strengthen the immune system's attack on advanced lung cancer. About 15 people with untreated stage IV non-small cell lung cancer will receive the combination. The main goal is t…

This early-phase study tests a combination of two drugs—cabozantinib and enfortumab vedotin—in people with advanced bladder cancer that has spread or cannot be removed. The goal is to find the best dose and see if the combo is safe and shrinks tumors. About 32 adults who have alr…

This study tests whether giving a combination of three chemotherapy drugs (gemcitabine, cisplatin, and nab-paclitaxel) before surgery can help shrink pancreatic tumors and improve outcomes. It is for people with pancreatic cancer that can be removed or is borderline removable. Th…

This study tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control tumor growth in people with advanced lung cancer whose disease is starting to worsen on immunotherapy alone. About 20 adults with stage III or IV non-small cell lung cancer will re…

This study tests whether a treatment made from healthy gut bacteria (microbiota therapy) can safely reduce the amount of drug-resistant germs living in the gut. About 60 adults who carry these superbugs will either get the treatment or be observed. The goal is to see if the thera…

This early-stage study tests whether infusions of special cells from donated umbilical cords (neonatal mesenchymal cells) are safe for people aged 4 to 29 with dilated cardiomyopathy, a condition where the heart is enlarged and weak. The goal is to see if these cells can improve …

This study is for people with advanced melanoma that has spread or cannot be removed by surgery. It tests whether giving two immunotherapy drugs (ipilimumab and nivolumab) in the morning works better than giving them later in the day. The goal is to see if timing can improve how …

This study tests an investigational drug called eptacog beta for people with Glanzmann thrombasthenia, a rare inherited bleeding disorder. Over 9 months, about 6 participants will use the drug to treat serious bleeding episodes, with an optional extension to see if regular infusi…

This early-stage trial tests a new drug (MRX-2843) combined with a standard treatment (osimertinib) for people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest and most effective dose and to see how well the combination works. About 69 particip…

This study tests if a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) can help people with a specific genetic type of advanced lung cancer (LKB1-mutant) that has stopped responding to standard treatments. The trial will enroll 50 …

This study tests a combination of two drugs, acalabrutinib and obinutuzumab, in people with untreated, slow-growing lymphomas like follicular lymphoma. The goal is to see if the combo can shrink tumors and control the disease. About 49 adults will take part, and researchers will …

This early-phase study is for people whose osteosarcoma has come back in the lungs. It combines an immunotherapy drug (atezolizumab) with precise radiation and surgery to remove tumors. The main goal is to see if this approach is safe and tolerable, with a secondary focus on cont…

This study tests whether the immunotherapy drug toripalimab can lower the chance of cancer coming back after surgery in people with a specific type of high-risk colon cancer (mismatch repair deficient stage IIB, IIC, or III). About 40 participants will receive the drug for up to …

This study tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help people with a specific type of advanced breast cancer (PD-L1 positive, triple-negative) that has spread. About 29 participants will receive this combination to …

This study tests a drug called zanidatamab given before surgery to people with HER2-positive colorectal cancer. The goal is to see if the drug can shrink or eliminate tumors, making surgery more effective. About 38 adults with early-stage cancer will take part, and researchers wi…

This study compares a continuous glucose monitor (Dexcom G7) to standard finger-stick blood sugar tests in 100 hospitalized adults with poorly controlled type 1 diabetes. The goal is to see which method keeps blood sugar in a healthy range (70-180 mg/dL) longer and reduces danger…

This study tests whether giving children with high-risk solid tumors a daily combination of sirolimus and low-dose chemotherapy for 12 months after standard treatment can keep the cancer from coming back. About 55 participants aged 1 to 30 years will take part. The goal is to see…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with an immunotherapy drug (pembrolizumab), for head and neck cancer that has returned or spread. The study aims to find the safest dose and check for side effects in 40 adul…

This early study tests a wearable device called Optune that creates low-intensity electric fields to disrupt cancer cell division. It is for adults with gliomas in the brainstem, a hard-to-treat area. The main goal is to see if the treatment is safe and tolerable for 10 participa…

This early-phase study tests whether adding a precise, high-dose external radiation treatment (SBRT) before a standard radioactive drug therapy (177Lu-DOTATATE) is safe and works better for people with large, inoperable neuroendocrine tumors of the digestive system. About 15 adul…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study compares two hormone therapy combinations for men with advanced prostate cancer who are also getting radiation. The goal is to see which combination causes less damage to the heart and blood vessels. Participants will be randomly assigned to receive either leuprolide o…

This study looks at whether giving pregnant women with sickle cell disease regular blood transfusions can reduce serious complications like pain crises, strokes, and pregnancy problems. About 50 women will be randomly assigned to receive either repeated transfusions or standard c…

This study tests two tools to help Black patients with advanced kidney disease get better care and delay the need for dialysis. One tool helps doctors identify high-risk patients, and the other provides health coaching. The goal is to see if these tools can help patients avoid st…

This study tests a shorter course of proton radiation for people with non-cancerous brain tumors. The goal is to see if fewer, higher-dose treatments can control tumor growth while reducing side effects and making treatment more convenient. About 70 adults with tumors like mening…

This study tests whether combining two drugs, cabozantinib and pembrolizumab, can shrink or slow the growth of advanced adrenal cancer that has spread or cannot be removed by surgery. The trial enrolls 21 adults with this rare cancer, regardless of prior treatments. The goal is t…

This study tests whether a single dose of azithromycin can eliminate N. meningitidis bacteria from the nose and throat of healthy carriers. About 1,120 college students who live on or near Emory University campuses will provide throat swabs before and after taking the antibiotic.…

This study looks at how Palynziq, a medication for phenylketonuria (PKU), improves diet, brain function, and nutrition. PKU is a genetic disorder that makes it hard to break down an amino acid called phenylalanine, which can build up and cause brain damage. The study will follow …

This study tests a drug called iberdomide, alone or with dexamethasone, in people with smoldering multiple myeloma at intermediate or high risk of developing active cancer. The goal is to see if the treatment can shrink or control the cancer cells and delay progression to symptom…

This study is testing whether a quick, non-invasive eye-tracking test can help screen for autism spectrum disorder (ASD) and other developmental delays in babies as young as 9 months old. Researchers will use a mobile device to measure how infants look at social scenes, then foll…

This study tests a new, non-invasive imaging device called qOBM that uses red light to scan skin lesions. Researchers want to see if it can help doctors diagnose skin cancer without needing a biopsy. Ten adults with skin lesions will be scanned, and the images will be compared to…

This study looks at whether a simple blood test can help doctors decide if a head CT scan is needed for people with mild head injuries. Researchers will collect blood samples from 350 adults and see if the test results match the need for imaging. The goal is to reduce unnecessary…

This study checks if a smartwatch can spot an irregular heartbeat (atrial fibrillation) in 500 older adults who had a stroke with an unknown cause. Participants wear a study smartwatch and a standard heart monitor for 30 days. Researchers compare the smartwatch data to the standa…

This study tests a program to help tribal households go smoke-free, aiming to reduce secondhand smoke exposure and lower cancer risk. About 575 adults who smoke or live with a smoker and do not already have a smoke-free home will take part. The program focuses on changing home sm…

This study tests whether L-DOPA, a drug used for Parkinson's disease, can improve loss of interest and pleasure (anhedonia) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will m…

This study compares a pain management plan that avoids opioids to one that includes them, for people having joint replacement or other orthopedic surgeries. About 80 adults will be randomly assigned to one of two groups and report their pain levels for 14 days after surgery. The …

This study tests a 12-week sleep improvement program for adults aged 18-40 with type 1 diabetes. The goal is to see if better sleep helps with blood sugar control and reduces diabetes-related distress. 300 participants will be followed for 9 months.

This study looks at whether releasing a small chest muscle (pectoralis minor) during reverse shoulder replacement helps reduce pain and improve movement. About 90 adults getting this surgery will be randomly assigned to have the muscle released or not. Researchers will track pain…

This study tests a program called CARE-D-Foot-Nav, which assigns a patient navigator to help adults with diabetes and foot ulcers manage their care. The goal is to see if this extra support leads to more ulcers healing completely within 20 weeks compared to usual care. The study …

This study tests whether baricitinib, a drug that blocks JAK signaling, can improve motivation and brain function in people with major depression who have high inflammation. About 100 adults aged 25-55 with depression and elevated C-reactive protein will receive the drug or place…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and uses heart rate biofeedback to help manage stress. About 128 teens aged 13-18 will either join the program right away or be placed on a waitlist. The goal is to see…

This study tests whether body-focused and non-body-focused interventions can reduce symptoms of dissociation in people who have experienced trauma. Researchers will enroll 350 participants at Emory University and the University of Pittsburgh. They will measure changes in brain ne…

This study tests a web-based rehab program for stroke survivors and their care partners (family members). The program focuses on problem-solving and arm exercises at home to improve the survivor's arm use and social participation while also supporting the caregiver's well-being. …

This study compares giving the chemotherapy drug oxaliplatin over 2 hours versus 6 hours to see if the longer infusion reduces nerve damage. About 60 people with gastrointestinal cancers who are scheduled for at least 4 cycles of FOLFOX6 chemotherapy will participate. The goal is…

This study tests a program called TRACT that helps cancer patients find transportation to their radiation treatments. Many patients miss or delay care due to travel problems, which can affect their health. The program will be offered to 76 adults with solid tumors who are getting…

This study tests whether a single dose of MDMA, given alongside two weeks of intensive exposure therapy, can help adults with PTSD feel better faster and longer. About 200 participants will receive either MDMA or a placebo during therapy. The main goal is to see if the combinatio…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can reduce chronic pain in military veterans. About 100 veterans receiving care at Emory Healthcare will use a headset at home to deliver mild electrical currents to the brain. The goal is to see if …

This study tests whether a 6-day low-dose steroid (Medrol Dosepak) can reduce pain, nausea, and the need for opioid painkillers in 180 adults having foot or ankle surgery. Participants will report their pain and nausea levels, and researchers will track how many opioids they use.…

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce chronic nerve pain in people with HIV. Researchers will enroll 60 adults with HIV and neuropathic pain to take the drug for 12 weeks and report their pain levels. The goal is to …

This study tests whether exercising to beat-accented music helps older adults with memory concerns stay active and improve thinking skills. Eighty participants aged 65+ will do strength and aerobic training for 6 months, some with music and some without. Researchers will track ph…

This study looks at whether giving extra doses of a steroid called dexamethasone after scoliosis surgery can help teens recover better. About 50 participants aged 10-18 will either get the standard one dose or three extra doses after surgery. Researchers will measure pain, nausea…

This study looks at whether mindfulness training can improve recovery for college athletes who need surgery for sports injuries. About 40 student-athletes will either get mindfulness training or standard care. Researchers will track pain, physical function, and mental health for …

This study compares two numbing medications, EXPAREL and bupivacaine, injected near the nerves around the ankle before total ankle replacement surgery. The goal is to see which provides better pain control and reduces the need for opioid painkillers afterward. About 104 adults ha…

This study looks at how different ways of giving voice therapy affect speaking ability over 12 months. It includes 120 adults with voice problems like muscle tension dysphonia or vocal fold lesions. Participants will receive behavioral voice therapy and be monitored through surve…

This early-stage study tests whether giving palliative radiotherapy together with the drug lurbinectedin is safe for people with extensive-stage small cell lung cancer that has spread beyond the chest. The goal is to relieve symptoms caused by the cancer. About 22 adults whose ca…

This study tests a web-based program for colorectal cancer patients on chemotherapy and their caregivers. The program targets common symptoms like fatigue, depression, sleep problems, pain, and brain fog. Researchers want to see if it's easy to use and helps improve quality of li…

This study tests whether a 12-week virtual physical therapy program is practical and helpful for children and young adults (ages 8-23) who are at least 100 days past a bone marrow transplant. Participants will have twice-weekly online sessions with a physical therapist and receiv…

This study looks at whether slowly lowering the dose of the steroid dexamethasone after brain tumor surgery can reduce side effects like high blood sugar and high blood pressure, while still preventing brain swelling. About 200 adults with certain brain tumors will be enrolled. T…

This study tests whether playing online games with others can reduce loneliness and improve social connections in older adults, including those with mild cognitive impairment (MCI). Researchers will measure changes in feelings of isolation, loneliness, and quality of life. The go…

This study tests a virtual, home-based exercise program for teens and young adults (ages 15-39) who had a brain tumor and received radiation. Many survivors struggle with memory and attention. The program aims to improve thinking and physical activity, and also looks at how exerc…

This study tests if a non-drug device called Alpha-Stim, which sends a mild electrical current through the head, can reduce pain and other symptoms in veterans with Gulf War Illness. About 130 veterans aged 40-80 will receive the treatment and have their pain levels and brain act…

This study tests whether a pain plan that limits opioids can help adults who get hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior hip replacement will be randomly assigned to either the limited-opioid plan or a standard…

This study tests a group training program called I-STRONG for teens with sickle cell disease who have chronic pain. The program teaches mind and body skills to help improve daily functioning and reduce pain. About 155 teens and their parents will take part to see if the program h…

This study tests a 6-week videoconference program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. Researchers want to see if the program is practical and helpful for improving sleep. About 80 participants will take part, a…

This study tests whether a therapy done at home via video calls can help infants with cerebral palsy use their weaker arm more. About 267 babies aged 4 to 13 months will be assigned to different sequences of the therapy or standard care. The goal is to see if the therapy improves…

This study tests whether in-person acupuncture or virtual acupressure can prevent the joint pain that often causes Black women to stop taking their breast cancer hormone therapy. About 150 Non-Hispanic Black postmenopausal women with early-stage breast cancer will be enrolled. Th…

This study tests an online course called CAN-DO designed to help family members and friends who care for someone with dementia. The course teaches skills for navigating healthcare, legal, and financial systems. 270 caregivers will take the course either right away or after a wait…

This study is testing a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. The goal is to see if this system improves patients' ability to care for themselves. The study will enroll 50 adults with heart f…

This study looks at whether taking progesterone pills can help transgender women feel less anxious or depressed, sleep better, and have more breast growth. About 40 participants who have been on hormone therapy for at least 6 months will take progesterone or a placebo. Researcher…

This study looks at 200 infants under 1 year old who had heart surgery for congenital heart disease. After their breathing tube is removed, they will get one of two standard breathing supports: high flow nasal cannula or non-invasive positive pressure ventilation. The goal is to …

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce withdrawal symptoms in people with opioid use disorder. About 100 participants will stay in a hospital for one week, receive either real or sham stimulation, and complete surveys and brain s…

This study tests a nerve block called ganglion impar neurolysis to reduce pain caused by radiation therapy for anal cancer. About 5 adults with localized anal cancer who report high pain scores will receive the injection near the tailbone. The goal is to see if this procedure hel…

This study tests whether giving arginine, a natural protein, can improve energy production in cells of children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses of arginine three times a day for up to five days. Researchers will measure chang…

This study is creating and testing a support program for Black transgender women who experience ongoing stigma. The program is designed with help from the community to reduce symptoms of distress, like PTSD and depression. About 40 participants will try the program to see if it i…

This study tests whether a personalized online exercise program can help gynecologic cancer survivors manage symptoms like pain, fatigue, sleep problems, and memory issues. About 40 women who have finished cancer treatment will try the program from home. The goal is to see if it'…

This study tests a small device that stimulates nerves in the ear to see if it can safely and effectively reduce pain in children with sickle cell disease during a pain crisis. About 20 children hospitalized for a sickle cell pain crisis will use the device. The goal is to see if…

This study compares two premedication regimens—methylprednisolone versus dexamethasone—to prevent allergic reactions to motixafortide in multiple myeloma patients undergoing stem cell collection. About 94 adults will participate to see which steroid works better and has fewer sid…

This study tests a short online program for people who have recently become caregivers for a friend or family member with dementia. The program teaches skills to manage symptoms, find support, and handle medications. Researchers want to see if it helps caregivers feel more in con…

This study looks at how the antibiotic doxycycline affects inflammation and the natural bacteria living in the body. Researchers will study 200 people with HIV or on HIV prevention medication (PrEP). The goal is to understand if doxycycline has extra effects beyond fighting infec…

This study looks at why people with PTSD often have higher heart disease risk. Researchers will test two daily therapies—deep breathing exercises and a mild nerve-stimulating device—to see if they can calm an overactive nervous system. About 120 veterans with or without PTSD and …

This study tests a new program called Compassion-Centered Spiritual Health Interventions for Teams (CCSH-TI) for hospital staff and providers. About 80 employees from a cancer center will be randomly assigned to either the program or their usual routine. The goal is to see if the…

This study explores a non-invasive way to weaken fear memories soon after a traumatic event, potentially lowering the risk of developing PTSD. Researchers will use brain imaging and mild sensory stimulation in 66 adults (some with PTSD) to see if they can disrupt how the brain st…

This study looks at whether a family history screening program can help more women in rural Georgia get tested for BRCA gene mutations linked to breast and ovarian cancer. About 3,200 women from public health clinics will take part. The goal is to see if the program increases the…

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect medical information and samples over time to better understand how these cancers develop and how to spot them early.…

This study is testing a new, non-invasive wearable patch with a microphone that listens to swallowing sounds in people who have trouble swallowing after a stroke. Researchers will collect these sounds during a standard swallowing X-ray test and use machine learning to find patter…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce suicidal thoughts and improve quality of life. About 130 English-speaking adults with bip…

This study compares a standard survivorship care plan to one that is simplified for people with lower health literacy. Researchers want to see if the tailored plan helps African American prostate cancer patients better understand their treatment side effects and follow-up needs. …

This study tests a group program called Weyera to see if it helps Ethiopian and Eritrean young adults (ages 18-29) in Atlanta build resilience and improve mental health. Researchers want to know if the program is acceptable, safe, and practical to run. The study will track how ma…

This study looks at how cancer patients and their doctors discuss immunotherapy. Researchers want to understand where patients get information, what they know, and how doctors explain the treatment. They will also test if educational videos can improve patient understanding. The …

This study looks at how the immune system responds in people with early-stage triple negative breast cancer who are receiving standard chemotherapy combined with immunotherapy (pembrolizumab). Researchers will measure certain immune markers in the blood and tumor tissue to see if…

This study looks at why people with PTSD have a higher chance of heart disease and high blood pressure. Researchers want to understand what causes high adrenaline levels during stress in PTSD patients. They will also test if a medicine called losartan can lower these adrenaline l…

This study looks at how the amount of muscle and fat in the body affects health in people with cystic fibrosis (CF) aged 16 to 30. Researchers will measure body fat distribution, lung function, and blood sugar control in 60 people with CF and 30 healthy volunteers. The goal is to…

This study looks at muscle scarring in the esophagus of people with achalasia, a swallowing disorder. Researchers want to see how scarring relates to muscle function tests. The goal is to understand the disease better so doctors can treat it earlier. About 80 adults with achalasi…

This study compares two different screening methods for PTSD in 804 pregnant Black women. The goal is to see which approach better identifies PTSD symptoms, improves use of prenatal and mental health care, and leads to healthier births. Participants will be in their first trimest…

This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke and have spatial neglect (trouble noticing things on one side). Researchers will measure changes in pointing, brain activity, and walking. The study i…

This study tests whether a special type of MRI (spectroscopic MRI) can help doctors better target proton radiation therapy for children with aggressive brain tumors. The MRI maps tumor metabolism without needing a contrast injection. Researchers will check if this approach improv…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure spikes during activity. Researchers will test if regular bike exercise, a drug called Kuvan, or amino acid supplements can help. The goal is to understand the bod…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and pH levels in 110 veterans with and without CKD. The goal is to understand the body's response, n…

This study intentionally gives healthy adults a mild flu infection to learn how the immune system fights the virus and how the virus spreads. Researchers will monitor symptoms and safety closely. The goal is to gather knowledge, not to test a treatment or vaccine.

This study collects information from 735 Alzheimer's patients aged 50-90 who are receiving FDA-approved anti-amyloid antibody treatments. Researchers will track changes in memory, thinking, and daily living skills over time. The goal is to understand how well these drugs work in …

This study looks at how mental stress impacts the heart and blood vessels in postmenopausal women with coronary microvascular dysfunction (CMD), a condition where the heart's tiny arteries don't work properly, causing chest pain. Researchers will compare stress responses in women…

This study aims to find out how much protein adults with Phenylketonuria (PKU) need, based on their genetics and the special medical foods they eat. Researchers will measure how the body processes a harmless tracer in 18 participants. The goal is to better understand protein need…

This study looks at how depression affects decision-making, especially when choices are hard. Researchers will use brain stimulation (TMS or TI) while participants play game-like tasks. The goal is to learn which brain regions are involved, not to treat depression. About 500 peop…

This study is for people with head and neck cancers who are getting radiation therapy. It uses special PET/CT scans to see how radiation affects the blood vessels in the neck. The goal is to learn if a newer scan method (F-18 NaF PET/CT) can detect these changes better than the s…

This study is testing a wearable stethoscope patch that listens to breath sounds in children with asthma. The goal is to see if the device can detect wheezing early, helping doctors manage asthma attacks. About 10 children hospitalized for asthma will wear the patch for up to 8 h…

This study looks at whether a balance exercise called IVA is safe and helpful for adults with vision problems, with or without inner-ear balance issues. Researchers will check if it improves eye reflexes, balance, and walking. About 100 adults aged 18 to 60 will take part, compar…

This study looks at how deep brain stimulation (DBS) affects the ability to stop or control actions in people with Parkinson's disease. Researchers will measure brain activity and test impulse control using simple computer tasks before, during, and after DBS surgery. The goal is …

This study aims to learn how the immune system fights the flu and how the virus spreads. Up to 50 healthy adults aged 18-49 will receive a nasal spray containing a specific flu virus (H3N2) and stay in the hospital for 8-12 days for close monitoring. The goal is to use this infor…

This study looks at how well newly diagnosed African-American men with early-stage prostate cancer understand what their doctor tells them about treatment. Researchers will give some patients an easy-to-read educational handout after their doctor visit and then interview them to …

This study looks at whether offering hearing tests close to home or online can help more head and neck cancer patients get their hearing checked during treatment. Chemotherapy and radiation can cause hearing loss, but many patients skip follow-up tests. The goal is to see if easi…

This study aims to understand why ventricular tachycardia (a fast, dangerous heart rhythm) happens in people with certain heart conditions. Researchers will measure the electrical signals in heart tissue from 10 participants to find the exact spots that cause the problem. The goa…

This study tests different message styles sent through MyChart, a patient portal, to see which ones get more people interested in joining research studies. Up to 100,000 patients will receive invitations, and researchers will track who responds 'interested,' 'not interested,' or …

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and test two methods to change lung volume: a chest ven…

This study looks at how the immune system of people with lymphoma responds to flu and COVID vaccines. Researchers will measure antibody levels and immune cells in 200 participants with different types of lymphoma and compare them to healthy individuals. The goal is to understand …

This study looks at whether drinking pasteurized milk containing killed (inactive) H5 flu virus particles could lead to a positive flu test from nose or throat swabs. The virus pieces are harmless and cannot cause illness. Researchers want to help the CDC understand if milk consu…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and tests ways to improve their fitness. Researchers will measure changes in exercise capacity and blood pressure in 156 participants, including CKD patients, kidney transplant recipients, an…

This study uses small pieces of heart tissue removed during necessary heart surgery in children with congenital heart disease. Researchers want to learn how calcium helps heart cells control their contraction force and how this differs between infants and adults. They also aim to…

This early-phase trial studies how to best give arginine (a natural amino acid) alongside whole brain radiation for people whose cancer has spread to the brain. Researchers will compare oral and IV arginine to find the dose that reaches the highest blood levels. The goal is to le…

This study looks at whether a camp that teaches teens and young women with PKU or MSUD about their condition and nutrition can improve their pregnancy outcomes and quality of life. Researchers will compare the results of women who attended the camp to those who did not. The study…

This study aims to find the best way to train early intervention providers to deliver high-quality services to children under 3 with communication delays or autism. Researchers will compare two training models for a program called Project ImPACT, measuring how well therapists lea…

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (stages 3 and 4). About 50 adults aged 45-85 who do not exercise regularly will take part. Researchers will measure blood pressure, artery …

This study aims to find the best ways to help families in Cambodia switch from wood or charcoal stoves to electric induction stoves. Researchers will track stove use and measure indoor air pollution in 6,150 households across 65 villages. The goal is to see if this switch is affo…

This study looks at how the amount of nicotine and the pH level in nicotine pouches change how they feel, how much people like them, and how addictive they might be. About 84 young adults who already use nicotine pouches will test different products in a lab setting. The goal is …

This study watches how doctors treat men with hemophilia A whose bodies have developed antibodies (inhibitors) that block standard clotting factor. Researchers will track different treatment plans, including immune tolerance therapy and newer drugs like emicizumab, to see which w…