Emory University

This study tested a new vaccine (NmCV-5) that protects against five types of meningitis bacteria in healthy infants in Mali. About 1,300 babies received either the new vaccine or an existing one at 9 or 15 months old. The goal was to see if the new vaccine is as safe and effectiv…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve electrical signals in the retina of people with diabetes who have early signs of eye damage. 230 adults with diabetes took part to find the best dose and understand how the drug works. The goal i…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare gene changes not normally treated with this medication. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin or bl…

This study tested whether adding two drugs—paricalcitol (a form of vitamin D) and hydroxychloroquine (an anti-malaria drug)—to standard chemotherapy could help people with advanced pancreatic cancer that has spread. Ten participants received the combination. The goal was to see i…

This small study tested a group discussion program for men who have sex with men in South Africa who struggle to take their HIV medication (either daily prevention pills or treatment pills). The goal was to see if talking about common mental health problems could help them stick …

This study tested whether a special type of MRI (called DSC perfusion MRI) can accurately tell the difference between radiation-caused tissue damage and tumor regrowth in people whose cancer has spread to the brain. Eight participants who had already received radiation therapy we…

This study compared two types of heart scans—CT and PET—to see how well they measure blood flow in people with coronary artery disease. Twenty adults who already needed a CT scan for their heart took part. The goal was to find out if the newer CT method works as well as the stand…

This study tested a healthy eating and weight gain prevention program delivered over the phone to people who called the 2-1-1 helpline. 512 adults aged 18-70 with a BMI of 20 or higher took part. The program aimed to improve diet quality and prevent weight gain using dietary guid…

This study tested a method called Targeted Indoor Residual Spraying (TIRS) to see if it could prevent diseases spread by Aedes mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico, took part. Researchers sprayed inside homes in certai…

This study tested a program called Go Sun Smart Georgia to see if it helps outdoor workers protect themselves from the sun. Over 300 workers from different worksites took part. Some worksites got the program right away, while others waited. The program included training and suppo…

This study tested a smartphone app called SavvyHER designed to help Black women in the southern U.S. access HIV prevention tools and sexual health information. Fifty-six Black women aged 18-44 who were HIV-negative and sexually active took part. The goal was to see if the app was…

This study tested whether a mobile app called WeTest-WeLink could help more high-risk men in China test for HIV and connect to care. About 1800 HIV-negative men who have sex with men used the app or received standard information. The goal was to see if the app increased HIV self-…

This study tested two programs to prevent drug misuse among 10th graders in rural Cherokee Nation high schools. About 919 students from 20 schools took part, with some schools starting the programs right away and others later. The goal was to see if these programs could reduce al…

This study looked at whether giving tamsulosin (Flomax) to men aged 50 and older during surgery can lower their chances of having trouble urinating or getting a urinary tract infection after a catheter is removed. The trial involved 87 men having elective abdominal surgery. Resea…

This study tested whether giving a short course of steroids (Medrol Dose Pak) after total knee replacement surgery can reduce pain, nausea, and the need for strong painkillers. About 100 adults with knee arthritis took part. The goal was to see if this common anti-inflammatory dr…

This study tested whether a battery-powered drill makes bone marrow biopsies less painful and easier for patients compared to the standard manual needle. 100 people with plasma cell disorders took part. The goal was to see if the drill could improve comfort and still get good-qua…

This study looked at whether a Chronic Disease Self-Management Program (CDSMP) can improve health and reduce doctor visits for African American women with lupus. Nearly 700 women took part. The program teaches skills to manage chronic conditions, and researchers measured things l…

This study looked at whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory loss or early dementia. Twenty-five participants took either the drug or a placebo for one year. Researchers tracked side effects and measured thinking s…

This study looked at two common surgeries for trigger finger, a condition where a finger gets stuck in a bent position. 80 adults were randomly assigned to have either an incision (cutting) or excision (removing part) of the A1 pulley in the hand. Researchers tracked pain, stiffn…

This study tested a type of radiation called hypofractionated radiosurgery for people with large brain metastases (tumors that spread from other cancers). The goal was to find the safest dose that could kill tumor cells while limiting damage to healthy brain tissue. Twenty-four a…

This small study tested whether a dietary supplement called citicoline could improve sleep and thinking in people with Alzheimer's disease. Twenty participants took the supplement, and researchers measured sleep quality and daytime sleepiness using questionnaires. The goal was to…

This study tested a drug called telotristat ethyl in 23 people with advanced pancreatic cancer who had lost at least 10% of their body weight. The goal was to see if the drug could help them stabilize or gain weight by reducing bowel movements. Maintaining weight may help patient…

This small study tested whether Botox injections can relieve the leg pain caused by Chronic Exertional Compartment Syndrome (CECS) in runners, potentially avoiding the need for surgery. Only 3 people took part, and the main goal was to measure pain changes over 3 months. The stud…

This study tested whether a dietary supplement called citicoline could improve sleep and thinking in 100 older adults with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's disease. Participants took citicoline or a placebo for several months. Researchers …

This study compared using a real-time continuous glucose monitor (CGM) to standard fingerstick testing in 116 adults with type 2 diabetes and foot ulcers. The goal was to see if CGM improves wound healing and reduces the burden of frequent fingersticks. Participants used either a…

This study tested whether taking zinc supplements could improve quality of life for patients with upper gastrointestinal cancers who were receiving chemotherapy. Researchers wanted to see if preventing zinc deficiency might help patients feel better during treatment. The study in…

This study tested a team-based approach to help children aged 5-18 recover from mild traumatic brain injury (concussion). The goal was to improve how doctors, families, and schools work together to support recovery. Researchers measured symptoms, quality of life, and return to no…

This completed study looked at how much doxycycline builds up in rectal and vaginal tissues after taking one pill daily for 7 days. 24 healthy adults (assigned male or female at birth) took part. The results will help design better ways to use doxycycline to prevent bacterial sex…

This study tested a program where parents helped their preterm babies with gentle sounds and touches in the hospital. The goal was to see if this could improve how the babies' brains process multiple senses at once, and later help with language and movement. 248 preterm infants t…

This study looked at how to improve follow-up care for new mothers who have health issues like high blood pressure or diabetes that raise their risk of serious problems after childbirth. Researchers interviewed women about barriers to care and then tested a new coordinated care s…

This study tested a quality improvement program where hospital doctors received regular reports comparing their antibiotic prescribing rates to their peers. The goal was to reduce unnecessary antibiotic use, which can lead to side effects like diarrhea and antibiotic-resistant in…

This study looked at whether providing educational materials about kidney transplants and the new organ allocation system to dialysis facilities could help reduce racial disparities in getting on the transplant waiting list. Over 56,000 patients at about 750 dialysis centers acro…

This study looked at how healthy adults' immune systems respond to the yellow fever vaccine. 239 people aged 18-45 received the vaccine and were monitored for up to a year. The goal was to understand the body's T cell responses to a viral infection, using the safe vaccine as a mo…

This study tested a wearable eye-tracking device (EyeControl) to help critically ill patients on breathing machines communicate. Thirty ICU patients tried using the device to call for help and answer questions. The goal was to see if it was safe, easy to use, and could help patie…

This study tested a special education course called Caregiving While Black-LIVE for Black caregivers of people with dementia. The goal was to help them feel more confident and supported when dealing with healthcare providers. Forty caregivers took part, and researchers measured t…

This study collected brain signals from 162 patients with serious brain injuries to help develop new ways to measure pressure inside the skull without surgery. Researchers used an ultrasound device to record blood flow while also tracking standard pressure readings. The goal was …

This study looked at how the antibiotic doxycycline gets into rectal and vaginal tissues after different doses. The goal is to find a single dose that could protect against both HIV and other sexually transmitted infections. 45 healthy adults took part, and researchers measured d…

This study looked at how well different doses of sugammadex work when the usual drug, neostigmine, doesn't fully reverse muscle relaxants after surgery. 46 adults having elective surgery took part. The goal was to find the fastest dose to restore normal muscle function. Results h…

This study tested a program called SPIRIT that helps people with end-stage kidney disease and their families plan for end-of-life care. The program involves two face-to-face sessions to improve understanding and agreement between patients and their chosen decision-makers. Researc…

This study looked at whether text message reminders can encourage people with diabetes or at risk for diabetes to get tested for COVID-19. About 290 people in Georgia took part, with half getting the text reminders and the other half not. The goal was to see if the reminders incr…