Emory University

This study tests if a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) can help people with a specific genetic type of advanced lung cancer (LKB1-mutant) that has stopped responding to standard treatments. The trial will enroll 50 …

This study tests a combination of two drugs, acalabrutinib and obinutuzumab, in people with untreated, slow-growing lymphomas like follicular lymphoma. The goal is to see if the combo can shrink tumors and control the disease. About 49 adults will take part, and researchers will …

This early-phase study is for people whose osteosarcoma has come back in the lungs. It combines an immunotherapy drug (atezolizumab) with precise radiation and surgery to remove tumors. The main goal is to see if this approach is safe and tolerable, with a secondary focus on cont…

This study tests whether the immunotherapy drug toripalimab can lower the chance of cancer coming back after surgery in people with a specific type of high-risk colon cancer (mismatch repair deficient stage IIB, IIC, or III). About 40 participants will receive the drug for up to …

This study tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help people with a specific type of advanced breast cancer (PD-L1 positive, triple-negative) that has spread. About 29 participants will receive this combination to …

This study tests a drug called zanidatamab given before surgery to people with HER2-positive colorectal cancer. The goal is to see if the drug can shrink or eliminate tumors, making surgery more effective. About 38 adults with early-stage cancer will take part, and researchers wi…

This study compares a continuous glucose monitor (Dexcom G7) to standard finger-stick blood sugar tests in 100 hospitalized adults with poorly controlled type 1 diabetes. The goal is to see which method keeps blood sugar in a healthy range (70-180 mg/dL) longer and reduces danger…

This study tests whether giving children with high-risk solid tumors a daily combination of sirolimus and low-dose chemotherapy for 12 months after standard treatment can keep the cancer from coming back. About 55 participants aged 1 to 30 years will take part. The goal is to see…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with an immunotherapy drug (pembrolizumab), for head and neck cancer that has returned or spread. The study aims to find the safest dose and check for side effects in 40 adul…

This early study tests a wearable device called Optune that creates low-intensity electric fields to disrupt cancer cell division. It is for adults with gliomas in the brainstem, a hard-to-treat area. The main goal is to see if the treatment is safe and tolerable for 10 participa…

This early-phase study tests whether adding a precise, high-dose external radiation treatment (SBRT) before a standard radioactive drug therapy (177Lu-DOTATATE) is safe and works better for people with large, inoperable neuroendocrine tumors of the digestive system. About 15 adul…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study compares two hormone therapy combinations for men with advanced prostate cancer who are also getting radiation. The goal is to see which combination causes less damage to the heart and blood vessels. Participants will be randomly assigned to receive either leuprolide o…

This study looks at whether giving pregnant women with sickle cell disease regular blood transfusions can reduce serious complications like pain crises, strokes, and pregnancy problems. About 50 women will be randomly assigned to receive either repeated transfusions or standard c…

This study tests two tools to help Black patients with advanced kidney disease get better care and delay the need for dialysis. One tool helps doctors identify high-risk patients, and the other provides health coaching. The goal is to see if these tools can help patients avoid st…

This study tests a shorter course of proton radiation for people with non-cancerous brain tumors. The goal is to see if fewer, higher-dose treatments can control tumor growth while reducing side effects and making treatment more convenient. About 70 adults with tumors like mening…

This study tests whether combining two drugs, cabozantinib and pembrolizumab, can shrink or slow the growth of advanced adrenal cancer that has spread or cannot be removed by surgery. The trial enrolls 21 adults with this rare cancer, regardless of prior treatments. The goal is t…

This study tests whether a single dose of azithromycin can eliminate N. meningitidis bacteria from the nose and throat of healthy carriers. About 1,120 college students who live on or near Emory University campuses will provide throat swabs before and after taking the antibiotic.…

This study looks at how Palynziq, a medication for phenylketonuria (PKU), improves diet, brain function, and nutrition. PKU is a genetic disorder that makes it hard to break down an amino acid called phenylalanine, which can build up and cause brain damage. The study will follow …

This study tests a drug called iberdomide, alone or with dexamethasone, in people with smoldering multiple myeloma at intermediate or high risk of developing active cancer. The goal is to see if the treatment can shrink or control the cancer cells and delay progression to symptom…

This study tests a new, non-invasive imaging device called qOBM that uses red light to scan skin lesions. Researchers want to see if it can help doctors diagnose skin cancer without needing a biopsy. Ten adults with skin lesions will be scanned, and the images will be compared to…

This study looks at whether a simple blood test can help doctors decide if a head CT scan is needed for people with mild head injuries. Researchers will collect blood samples from 350 adults and see if the test results match the need for imaging. The goal is to reduce unnecessary…

This study checks if a smartwatch can spot an irregular heartbeat (atrial fibrillation) in 500 older adults who had a stroke with an unknown cause. Participants wear a study smartwatch and a standard heart monitor for 30 days. Researchers compare the smartwatch data to the standa…

This study tests a program to help tribal households go smoke-free, aiming to reduce secondhand smoke exposure and lower cancer risk. About 575 adults who smoke or live with a smoker and do not already have a smoke-free home will take part. The program focuses on changing home sm…

This study tests a virtual, home-based exercise program for teens and young adults (ages 15-39) who had a brain tumor and received radiation. Many survivors struggle with memory and attention. The program aims to improve thinking and physical activity, and also looks at how exerc…

This study tests if a non-drug device called Alpha-Stim, which sends a mild electrical current through the head, can reduce pain and other symptoms in veterans with Gulf War Illness. About 130 veterans aged 40-80 will receive the treatment and have their pain levels and brain act…

This study tests whether a pain plan that limits opioids can help adults who get hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior hip replacement will be randomly assigned to either the limited-opioid plan or a standard…

This study tests a group training program called I-STRONG for teens with sickle cell disease who have chronic pain. The program teaches mind and body skills to help improve daily functioning and reduce pain. About 155 teens and their parents will take part to see if the program h…

This study tests a 6-week videoconference program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. Researchers want to see if the program is practical and helpful for improving sleep. About 80 participants will take part, a…

This study tests whether a therapy done at home via video calls can help infants with cerebral palsy use their weaker arm more. About 267 babies aged 4 to 13 months will be assigned to different sequences of the therapy or standard care. The goal is to see if the therapy improves…

This study tests whether in-person acupuncture or virtual acupressure can prevent the joint pain that often causes Black women to stop taking their breast cancer hormone therapy. About 150 Non-Hispanic Black postmenopausal women with early-stage breast cancer will be enrolled. Th…

This study tests an online course called CAN-DO designed to help family members and friends who care for someone with dementia. The course teaches skills for navigating healthcare, legal, and financial systems. 270 caregivers will take the course either right away or after a wait…

This study is testing a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. The goal is to see if this system improves patients' ability to care for themselves. The study will enroll 50 adults with heart f…

This study looks at whether taking progesterone pills can help transgender women feel less anxious or depressed, sleep better, and have more breast growth. About 40 participants who have been on hormone therapy for at least 6 months will take progesterone or a placebo. Researcher…

This study looks at 200 infants under 1 year old who had heart surgery for congenital heart disease. After their breathing tube is removed, they will get one of two standard breathing supports: high flow nasal cannula or non-invasive positive pressure ventilation. The goal is to …

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce withdrawal symptoms in people with opioid use disorder. About 100 participants will stay in a hospital for one week, receive either real or sham stimulation, and complete surveys and brain s…

This study tests a nerve block called ganglion impar neurolysis to reduce pain caused by radiation therapy for anal cancer. About 5 adults with localized anal cancer who report high pain scores will receive the injection near the tailbone. The goal is to see if this procedure hel…

This study tests whether giving arginine, a natural protein, can improve energy production in cells of children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses of arginine three times a day for up to five days. Researchers will measure chang…

This study is creating and testing a support program for Black transgender women who experience ongoing stigma. The program is designed with help from the community to reduce symptoms of distress, like PTSD and depression. About 40 participants will try the program to see if it i…

This study tests whether a personalized online exercise program can help gynecologic cancer survivors manage symptoms like pain, fatigue, sleep problems, and memory issues. About 40 women who have finished cancer treatment will try the program from home. The goal is to see if it'…

This study tests a small device that stimulates nerves in the ear to see if it can safely and effectively reduce pain in children with sickle cell disease during a pain crisis. About 20 children hospitalized for a sickle cell pain crisis will use the device. The goal is to see if…

This study compares two premedication regimens—methylprednisolone versus dexamethasone—to prevent allergic reactions to motixafortide in multiple myeloma patients undergoing stem cell collection. About 94 adults will participate to see which steroid works better and has fewer sid…

This study tests a short online program for people who have recently become caregivers for a friend or family member with dementia. The program teaches skills to manage symptoms, find support, and handle medications. Researchers want to see if it helps caregivers feel more in con…

This study looks at how depression affects decision-making, especially when choices are hard. Researchers will use brain stimulation (TMS or TI) while participants play game-like tasks. The goal is to learn which brain regions are involved, not to treat depression. About 500 peop…

This study is for people with head and neck cancers who are getting radiation therapy. It uses special PET/CT scans to see how radiation affects the blood vessels in the neck. The goal is to learn if a newer scan method (F-18 NaF PET/CT) can detect these changes better than the s…

This study is testing a wearable stethoscope patch that listens to breath sounds in children with asthma. The goal is to see if the device can detect wheezing early, helping doctors manage asthma attacks. About 10 children hospitalized for asthma will wear the patch for up to 8 h…

This study looks at whether a balance exercise called IVA is safe and helpful for adults with vision problems, with or without inner-ear balance issues. Researchers will check if it improves eye reflexes, balance, and walking. About 100 adults aged 18 to 60 will take part, compar…

This study looks at how deep brain stimulation (DBS) affects the ability to stop or control actions in people with Parkinson's disease. Researchers will measure brain activity and test impulse control using simple computer tasks before, during, and after DBS surgery. The goal is …

This study aims to learn how the immune system fights the flu and how the virus spreads. Up to 50 healthy adults aged 18-49 will receive a nasal spray containing a specific flu virus (H3N2) and stay in the hospital for 8-12 days for close monitoring. The goal is to use this infor…

This study looks at how well newly diagnosed African-American men with early-stage prostate cancer understand what their doctor tells them about treatment. Researchers will give some patients an easy-to-read educational handout after their doctor visit and then interview them to …

This study looks at whether offering hearing tests close to home or online can help more head and neck cancer patients get their hearing checked during treatment. Chemotherapy and radiation can cause hearing loss, but many patients skip follow-up tests. The goal is to see if easi…

This study aims to understand why ventricular tachycardia (a fast, dangerous heart rhythm) happens in people with certain heart conditions. Researchers will measure the electrical signals in heart tissue from 10 participants to find the exact spots that cause the problem. The goa…

This study tests different message styles sent through MyChart, a patient portal, to see which ones get more people interested in joining research studies. Up to 100,000 patients will receive invitations, and researchers will track who responds 'interested,' 'not interested,' or …

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and test two methods to change lung volume: a chest ven…

This study looks at how the immune system of people with lymphoma responds to flu and COVID vaccines. Researchers will measure antibody levels and immune cells in 200 participants with different types of lymphoma and compare them to healthy individuals. The goal is to understand …

This study looks at whether drinking pasteurized milk containing killed (inactive) H5 flu virus particles could lead to a positive flu test from nose or throat swabs. The virus pieces are harmless and cannot cause illness. Researchers want to help the CDC understand if milk consu…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and tests ways to improve their fitness. Researchers will measure changes in exercise capacity and blood pressure in 156 participants, including CKD patients, kidney transplant recipients, an…

This study uses small pieces of heart tissue removed during necessary heart surgery in children with congenital heart disease. Researchers want to learn how calcium helps heart cells control their contraction force and how this differs between infants and adults. They also aim to…

This early-phase trial studies how to best give arginine (a natural amino acid) alongside whole brain radiation for people whose cancer has spread to the brain. Researchers will compare oral and IV arginine to find the dose that reaches the highest blood levels. The goal is to le…

This study looks at whether a camp that teaches teens and young women with PKU or MSUD about their condition and nutrition can improve their pregnancy outcomes and quality of life. Researchers will compare the results of women who attended the camp to those who did not. The study…

This study aims to find the best way to train early intervention providers to deliver high-quality services to children under 3 with communication delays or autism. Researchers will compare two training models for a program called Project ImPACT, measuring how well therapists lea…

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (stages 3 and 4). About 50 adults aged 45-85 who do not exercise regularly will take part. Researchers will measure blood pressure, artery …

This study aims to find the best ways to help families in Cambodia switch from wood or charcoal stoves to electric induction stoves. Researchers will track stove use and measure indoor air pollution in 6,150 households across 65 villages. The goal is to see if this switch is affo…

This study looks at how the amount of nicotine and the pH level in nicotine pouches change how they feel, how much people like them, and how addictive they might be. About 84 young adults who already use nicotine pouches will test different products in a lab setting. The goal is …

This study watches how doctors treat men with hemophilia A whose bodies have developed antibodies (inhibitors) that block standard clotting factor. Researchers will track different treatment plans, including immune tolerance therapy and newer drugs like emicizumab, to see which w…