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Could a 6-Day steroid pill reduce opioid needs after surgery?

NCT ID NCT06780202

Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a 6-day course of the steroid Medrol (methylprednisolone) can lower pain, nausea, and the need for opioid painkillers after foot or ankle surgery. About 180 adults having surgery at Emory will take either the steroid or a placebo, plus a small supply of hydrocodone for breakthrough pain. The goal is to see if the steroid helps people recover with fewer opioids and fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Methylprednisolone (a corticosteroid, given as a 6-day tapering course)
What this could lead to
If it works, this could offer a way to manage post-surgery pain with fewer opioids, lowering the risk of dependence.
What could go wrong
This is a small Phase 2 trial, so results are preliminary. The steroid may not reduce pain or nausea significantly, and it carries risks like infection or delayed wound healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 95 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: -Emory Orthopedic patients undergoing foot and ankle surgery Exclusion Criteria: * Concurrent or significant injuries to other bones or organs * Local infections * History of alcohol or medical abuse, including prior opioid abuse * Smoking * History of severe heart disease, renal failure, liver dysfunction, active peptic ulcer disease, diabetes, rheumatoid arthritis, neurological or psychiatric diseases that could influence pain perception * Pre-existing immune suppression * Those deemed possibly non-compliant by the study team and, * All vulnerable populations (those unable to give consent, juveniles, pregnant women, prisoners, cognitively impaired and non-English speaking).

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Conditions

The condition(s) this trial relates to.

ankle injury disease Foot Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Achilles tendon injury Ankle injuries and disorders Foot injuries and disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Emory Musculoskeletal Institute, Emory Orthopaedics & Spine Center

    RECRUITING

    Atlanta, Georgia, 30329, United States

  • Emory Sports Medicine Complex and Emory Orthopaedics and Spine Center

    RECRUITING

    Johns Creek, Georgia, 30022, United States

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