University Of Alabama At Birmingham

This study tests a student-designed campaign to increase HPV vaccination among teens in Chambers County, Alabama, which has high cervical cancer rates. About 29 high school students will create and run the campaign, with the goal of getting more young people vaccinated. The proje…

This study tests whether adding iberdomide (a pill) with other drugs can eliminate tiny amounts of multiple myeloma that remain after a stem cell transplant. About 80 adults who still have detectable cancer cells after transplant will receive these combinations. The goal is to ac…

This study looks at whether losing weight with a special very low-calorie diet (Optifast VLCD) can lower the amount of oxalate in urine. Oxalate is a substance that can form kidney stones. The study includes 14 obese adults who have had calcium oxalate kidney stones before. Parti…

This study tests whether checking blood pressure at home and talking to a pharmacist by phone each week can help manage high blood pressure after an ER visit. Twenty-four adults will take part, with half using the telehealth program and half getting usual care. The program lasts …

This study tests whether siltuximab can lessen the severity of cytokine release syndrome (CRS) and nerve-related side effects (ICANS) in 30 people receiving CAR-T cell therapy for blood cancers like lymphoma and multiple myeloma. The goal is to help patients recover faster from t…

This study aims to find the most effective weight loss strategy for adults with prediabetes and physical disabilities. Over 16 weeks, participants will try different diet plans, and those who don't lose enough weight will get extra exercise or time-restricted eating. The goal is …

This early-stage study tests whether a new type of cell therapy, made from a patient's own genetically modified immune cells, is safe for people with newly diagnosed glioblastoma (a fast-growing brain cancer). The treatment is given alongside standard chemotherapy. The goal is to…

This early-stage study tests adding loncastuximab tesirine to the standard drug acalabrutinib for people with chronic lymphocytic leukemia (CLL). The main goal is to find the safest dose of the combination. Researchers will also check if the treatment can make cancer cells undete…

This study compares a video telehealth pulmonary rehabilitation program to standard care for people hospitalized with a COPD flare-up. The goal is to see if the virtual program reduces hospital readmissions and improves breathing and quality of life. About 301 adults aged 40 and …

This study aimed to see if adding the drug vibegron to standard Botox injections could better control urgent, frequent urination in women with overactive bladder that didn't improve with other treatments. The plan was to compare a group receiving Botox plus vibegron against a gro…

This study tests whether delivering healthy meals to the homes of pregnant women with overweight or obesity can help them gain a healthy amount of weight during pregnancy. Researchers will track weight changes and also look at food security and stress levels. The study includes 3…

This study looks at whether eating all meals earlier in the day and using timed light therapy can help control blood sugar in adults with type 2 diabetes. About 344 participants will follow these routines to see if they improve glucose levels, sleep, weight, and mood. The goal is…

This study tested whether placing preterm or low birth weight babies in plastic bags right after birth helps prevent hypothermia (dangerously low body temperature). About 182 babies born in a hospital were included. The bags were used along with standard World Health Organization…

This study looks at whether giving a set amount of immune cells (called CD3+ T cells) from a brother or sister donor makes stem cell transplants more predictable and easier to manage. About 20 adults receiving a transplant from a fully matched sibling will get a fixed dose of the…

This study tests a combination of two drugs—niraparib and trastuzumab—in people with metastatic HER2-positive breast cancer, an aggressive form of the disease. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. About 46 women with advanced …

This pilot study aimed to see if giving sildenafil (a drug that relaxes blood vessels) to women during labor could reduce the need for emergency C-sections or instrument-assisted births and lower the risk of newborn death or breathing problems. The trial was planned for low-resou…

This study looks at whether taking folic acid (a B vitamin) can help people living in areas with high arsenic levels remove more arsenic from their bodies. Arsenic is a toxic metal that can cause lung problems and other diseases. The study will involve 100 adults in Birmingham, A…

This study looks at whether adding extra nutrients (fortification) to breast milk earlier (between days 4-7) versus later (days 10-14) helps very preterm infants (born 29-33 weeks) grow better and have healthier gut bacteria. Eighty infants are taking part. The goal is to see if …

This study looks at whether giving extra protein in human milk during the first two weeks of life helps extremely preterm infants (born at 28 weeks or earlier) gain more lean body mass and develop a healthier mix of gut bacteria. About 150 babies will take part. The goal is to im…

This study looked at whether providing home-delivered meals to Black, low-income pregnant women with overweight or obesity could improve their diet and help them gain a healthy amount of weight during pregnancy. Seventeen women received meals, and researchers measured changes in …

This early-phase study tests the safety of a lab-made virus (M032) designed to attack recurrent brain tumors like glioblastoma. About 29 participants who have already tried standard treatments will receive the virus directly into their tumor. The goal is to find the safest dose a…

This study looks at the best way to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop before a possible early birth. Steroids can raise blood sugar, which may be harmful. The trial compares three insulin strategies to fi…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people living with HIV reduce unhealthy alcohol use. About 308 participants in Alabama will receive either the combined program or brief counseling alone. The…

This study helps 200 adults with gout, especially African Americans in the Southeast, get better care through an emergency department program. It focuses on improving treatment for flare-ups and long-term management. The study also aims to increase minority involvement in medical…

This study compares two surgical techniques to treat gum recession, where gums pull away from teeth. About 22 adults with gum recession and thin gum tissue will receive a graft using donated skin tissue. The goal is to see which method covers more exposed tooth root and improves …

This study compares a new, less invasive method (endo-AVF) to traditional surgery for creating the blood vessel connections needed for dialysis. The goal is to see if the new method works as well or better at making the connection usable for dialysis. 21 adults will take part to …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and used the app with coaching support. H…

This study aimed to see if adding the diabetes drug acarbose to standard immunotherapy was safe and could help control advanced kidney cancer. It planned to enroll people with metastatic renal cell carcinoma. However, the study was withdrawn before any participants were enrolled.

This study tests a precise, non-invasive radiation treatment called frameless virtual cone radiosurgery for people with severe tremor from essential tremor or Parkinson's disease who cannot have deep brain stimulation. The goal is to reduce tremor and improve daily activities. Fo…

This study tests the drug baricitinib in 15 women with frontal fibrosing alopecia, a condition that causes scarring hair loss and eyebrow loss. The goal is to see if it safely reduces disease activity and improves symptoms like itching and redness. Participants take the drug and …

This study tests whether a low dose of tamoxifen, a hormone-blocking drug, can reduce the risk of breast cancer in people who have had radiation therapy for other cancers. About 84 participants took either low-dose tamoxifen or a placebo for a period of time. The main goal was to…

This study tests whether giving antiviral medication to pregnant women at high risk and their newborns can prevent the baby from getting hepatitis B. About 450 women and their infants in Africa will take part. The goal is to find a safe and effective way to stop the virus from pa…

This study tests whether fixing up neighborhoods—adding better lighting, sidewalks, green spaces, and bringing in health vans—can lower cancer risk in poor areas. About 300 Black adults living in high-poverty neighborhoods will take part. Researchers will measure stress levels an…

This study tests a program to prevent high blood pressure in 528 rural Black adults in Alabama who have higher-than-normal blood pressure but not yet high enough for medication. Participants from 30 churches will either get group health education and online resources, or the same…

This study aimed to see if combining kangaroo mother care (continuous skin-to-skin contact) with a plastic bag could prevent dangerous low body temperature in preterm infants born between 32 and 36 weeks. The trial was withdrawn before any babies were enrolled, so no results are …

This study looks at whether eating a better diet and cutting calories can improve physical function, thinking, pain, fatigue, mood, and anxiety in 100 adults with multiple sclerosis. Participants have relapsing-remitting or secondary progressive MS and are overweight or obese. Re…

This study tests a new, non-invasive radiation method called Virtual Cone radiosurgery for people with trigeminal neuralgia whose pain is not controlled by medication. The goal is to see if this frameless technique can safely and effectively reduce severe facial pain. About 40 ad…

This study tests a 6-month online program designed to help people with multiple sclerosis (MS) increase their physical activity. The program uses coaching and goal-setting to encourage exercise, with the goal of improving walking, thinking, fatigue, mood, and quality of life. Abo…

This study tests whether three natural supplements—curcumin, resveratrol, and stinging nettle—can improve physical and mental health in veterans with Gulf War Illness. About 390 veterans from across the U.S. can join from home using online surveys. The goal is to find safe, acces…

This study tests whether elastic tape (KT tape) works better than a traditional arm sling for children with broken collarbones. About 50 kids will wear either tape or a sling, and researchers will track their pain, disability, and painkiller use. The goal is to see if the tape pr…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma control and insulin resistance in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, inflammation, and breathing tests. Only 7 participants are enrolled…

This study looks at whether a plant-based omega-3 supplement from flaxseed can reduce pain and improve daily life for children with sickle cell disease. About 30 children aged 5 to 18 will take flaxseed and report their pain levels and quality of life. The goal is to find a more …

This pilot study tested whether using a blood flow restriction (BFR) cuff during physical therapy helps elderly patients (65+) rebuild leg muscle and strength after hip fracture surgery. Twenty participants received either standard therapy or therapy with BFR. The study measured …

This study tested whether Bodewell eczema products are safe and effective for treating atopic dermatitis, a common skin condition. Fifteen adults used the products for 12 weeks. Researchers measured skin improvement and quality of life changes. The goal was to see if these over-t…

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive brief, non-judgmental conversations to set their own goals for brushing and flossing. Researchers will me…

This study was designed to see if a procedure called transarterial embolization is safe and possible for children aged 2-18 with incurable soft tissue sarcoma. The procedure involves blocking blood flow to tumors using tiny particles. The goal was to help control the disease and …

This study tests a program called UPHOLDS to help older adults with advanced heart failure feel better and improve their quality of life. 64 participants will try different combinations of support, like extra education sessions, financial coaching, and a one-time visit with a pal…

This study aimed to see if very low, non-hallucinogenic doses of psilocybin could reduce demoralization—feelings of hopelessness and meaninglessness—in adults. Researchers planned to give microdoses to 0 participants and measure changes in mood and thinking. However, the study wa…

This study was designed to see if a specific nerve block could reduce pain and opioid use after knee arthroscopy. It planned to enroll adults needing knee surgery, but was withdrawn before any participants joined. No results are available.

This study tests a 12-week coaching program called CuRB-IT for family caregivers of people with dementia. The goal is to help caregivers manage care-resistant behaviors (like refusing help) and improve their own coping skills. 266 caregivers will be randomly assigned to start the…

This study tests whether trained lay coaches can help family caregivers of people with advanced cancer feel less distressed and more supported. About 387 caregivers from rural and minority communities in the Southern U.S. will receive coaching sessions or usual care. The goal is …

This study was designed to see if giving sildenafil (a blood pressure medicine) to mothers during labor could reduce complications like fetal distress and birth asphyxia in low-resource areas. It planned to enroll pregnant women at term and compare sildenafil to a placebo. Howeve…

This study tests a new program where a health coach helps Black adults with advanced heart failure manage their pain. The goal is to see if the program is practical and acceptable to patients. Ten participants will try different combinations of pain management support, and resear…

This study uses a special radioactive tracer and PET/MRI scans to track white blood cells entering the brain in people with fibromyalgia, chronic fatigue syndrome, or multiple sclerosis, as well as healthy volunteers. The goal is to better understand brain inflammation in these c…

This study looks at whether providing easy-to-understand information can help relatives of people with Lynch syndrome decide whether to get genetic counseling or testing. About 185 adult family members will be randomly given either a standard letter or a letter plus a booklet. Re…

This study looks at whether older adults with prediabetes have slower thinking and less brain energy use compared to those with normal blood sugar. Researchers will test if a single dose of a ketone supplement can temporarily improve brain function and energy use during thinking …

This lab study compares how two materials—Platelet Rich Fibrin (PRF) and a commercial product (GEM21S)—release a key growth factor (PDGF-BB) that helps bone heal. Researchers will test these materials with and without bone graft material to find the best combination for future tr…

This study looks at how being obese might increase the body's natural production of oxalate, a substance that can lead to kidney stones. Researchers will give 40 adults (both obese and non-obese) a special low-oxalate diet and measure their urine oxalate levels. The goal is to be…

This study looks at whether adults with newly diagnosed acute myeloid leukemia (AML) can safely skip an immediate second round of chemotherapy based on results from a standard mid-induction bone marrow biopsy. Researchers will track how many patients achieve complete remission wi…

This study compares two approaches to help adults who had a stroke and still have mild to moderate thinking problems. Both groups use a computer game to train how fast they process information. One group also gets in-person training on everyday tasks, while the other learns about…

This study looks at how sleep and your body's internal clock affect your blood pressure at night. Researchers will measure melatonin, body temperature, and blood pressure in 1,427 adults. No treatment is given—the goal is simply to learn more about these connections.

This study uses advanced PET/MRI scans to see if a heart attack triggers inflammation in the brain. Researchers will compare 6 participants who recently had a heart attack with a control group. The goal is to better understand how heart disease affects the brain and to guide futu…

This study aimed to see if a general form of group therapy, using skills common to all major therapies, could help adults with depression, anxiety, PTSD, or stress. It was designed for people 18 and older with self-reported distress, but excluded those with recent self-harm, suic…

This study aims to develop a new test called EDSPD that measures how well the sinuses work in people with chronic rhinosinusitis (CRS). Researchers will give a drug called ivacaftor to 30 adults with CRS who have had a recent gram-negative bacterial infection. The goal is to see …

This study looks at whether regularly measuring body fat in very preterm infants (born 28-32 weeks) can help them avoid too much fat gain by 3 months old. About 50 babies will be tracked using a special body-composition test. The goal is to see if early monitoring leads to health…

This study looks at blood stem cells (called EPCs) in people with diabetes and healthy volunteers to see if these cells work differently in diabetes. Researchers want to know if the function of these cells can predict diabetic retinopathy, an eye disease that can cause blurred vi…

This study aimed to see if a new type of imaging (PET/MRI) could detect how well targeted therapy was working in people with stage IV HER2+ breast cancer. It planned to compare scans taken before and during treatment. However, the study was withdrawn before any participants were …

This pilot study explores whether a remotely delivered resistance training program is practical and well-liked by Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. The study will enroll 37 participants and measure how many join,…

This study uses a non-invasive breathing test called forced oscillometry to measure lung function in 600 newborn infants, both full-term and premature, with and without lung conditions like respiratory distress syndrome or bronchopulmonary dysplasia. The test involves sending sma…

This study asks up to 30 adults with spinal cord injury what they want in an exercise program. Researchers will use surveys and interviews to learn what helps people start and stick with physical activity. The goal is to design better exercise programs that fit their needs.

This study aimed to see if combining patient surveys, staff training, and telemedicine could improve mental health and substance use care for people living with HIV. The program was planned for adults receiving HIV care at five clinics in Alabama. However, the study was withdrawn…

This study looks at how the brain changes and adapts after losing central vision, which happens in conditions like macular degeneration. Researchers will test healthy adults aged 18-30 to understand how training can improve visual skills. The goal is to use these insights to deve…

This study looks at how vision loss from glaucoma affects the ability of older adults to move around and go places. Researchers will track 88 participants with glaucoma to see how far they travel and if dim lighting makes it harder. The goal is to better understand the real-world…

This study looks at how the kidneys process a substance called glycolate into oxalate, which can form kidney stones. Fifteen healthy adults follow a special low-oxalate diet and receive a safe, labeled form of glycolate to track its conversion. The goal is to better understand no…

This study looks at whether a person's insurance status affects how well their pain relief works during a C-section. Researchers will review records of 2,500 pregnant adults to see if there are differences in care. The goal is to understand and reduce health disparities in labor …

This study looks at how exercise affects the gut microbiome (the bacteria living in your gut) and whether those changes help reduce fatigue and other symptoms in breast cancer survivors. About 126 women who have finished primary treatment for breast cancer and still feel tired wi…

This study looks at whether a coordinated emergency system can help more people with severe strokes get the advanced treatment they need. About 4,893 patients in Alabama will be part of this effort. The goal is to reduce delays and improve access to care, especially for those in …

This study looks at ways to help primary care doctors better screen and treat urinary incontinence in women Veterans. About 2,500 women Veterans will take part, using a mobile health app and extra training for their doctors. The goal is to find the best way to deliver care remote…

This study looks at how obesity changes the way the body handles oxalate, a key substance in calcium oxalate kidney stones. Researchers will compare normal-weight and obese stone formers to understand differences in oxalate absorption, kidney processing, and natural production. T…

This study looks at brain images from 156 people experiencing their first episode of psychosis who have never taken medication. Researchers want to find out why some patients get better with standard treatment while others do not. By using different types of brain scans, they hop…

This study follows 830 women in Alabama to learn why some get HIV or sexually transmitted infections (STIs) and how to better use prevention tools like PrEP. Participants must be HIV-negative, have had a recent STI, and own a smartphone. The goal is to gather information, not to …

This study tests whether a telehealth-based Living Donor Navigator program helps more kidney transplant candidates find living donors compared to standard care. About 347 adults with end-stage kidney disease who are already being evaluated for a transplant will take part. The goa…

This study tests a training program called CASCADE for family caregivers of people newly diagnosed with advanced cancer. The goal is to see which parts of the training best help caregivers support their loved one in making medical decisions. 256 caregivers will receive different …

This study looks at whether wearable devices (like smartwatches) can help cancer survivors track their symptoms at home. About 20 people will wear the device and report how they feel. The goal is to see if this approach is practical and can improve care.

This study was designed to explore whether problems with mitochondria — the energy centers of cells — play a role in causing heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers. However, the study was withdr…

This study explores whether taking antidepressants can lower gum inflammation in people who have both depression and chronic gum disease (periodontitis). Researchers will measure inflammatory markers in the fluid around the teeth and analyze plaque bacteria. The study involves 92…

This study was designed to look for early signs of high blood pressure in the lungs after mitral valve surgery. Researchers planned to use blood tests and heart imaging to find problems before they become dangerous. However, the study was withdrawn before enrolling any participan…

This study looks at how approved seasonal flu vaccines affect the body's immune response, specifically antibodies and memory B cells, in younger adults (ages 18-50) and older adults (ages 65-80). Researchers aim to understand how age and past vaccination history change the way th…

This study looks at whether a stress management and relaxation program, delivered through video calls, is practical and helpful for breast cancer survivors living in high-need areas of Alabama. About 25 survivors will take part, and researchers will also gather feedback from comm…

This study aimed to test a type of talk therapy called acceptance and commitment therapy (ACT) for men who engage in chemsex (using drugs during sex). It planned to enroll men aged 18-65 in Alabama who had done chemsex in the past six months. However, the study was withdrawn befo…

This study was designed to use a special PET scan tracer to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of the neck arteries without symptoms). It planned to compare those with severe versus mild narrowing. However, the study was withd…

This study tests a new, tiny camera (micro OCT) that can take detailed pictures of the airways in the lungs and nose. Researchers want to see if it works well in adults with cystic fibrosis and healthy volunteers. The goal is to better understand early lung damage, which could le…