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Can a better diet ease MS symptoms? new study tests diet quality and calorie cutting

NCT ID NCT05327322

Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether improving diet quality and reducing calories can help physical function, thinking, pain, fatigue, mood, and anxiety in 100 adults with relapsing-remitting or secondary progressive multiple sclerosis. Participants receive prepared meals and behavioral support over 32 weeks. The goal is to see if these dietary changes can ease MS symptoms and improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dietary intervention (glycemic load and calorie restriction)
What this could lead to
If successful, this could point toward a simple dietary approach to help manage symptoms like fatigue, pain, and mobility issues in multiple sclerosis.
What could go wrong
This is a relatively small, early-stage study (100 participants) testing behavioral changes, not a drug. Results may not apply to all MS patients, and dietary adherence can be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with RRMS or SPMS * BMI 25-50 kg/m2 (overweight/obese) * EDSS ≤6.5 (able to walk 100m with or without assistance) * If on disease-modifying treatment (DMT), stable for 6 months * If not on DMT, no DMT in previous 6 months * No expected change to DMT in next 34 weeks * Responsible for food preparation or have input into food preparation Exclusion Criteria: * MS relapse in previous 30 days * Unable to walk 25 feet with or without assistive device * Pregnant or breastfeeding * Current use of insulin or sulfonylurea agents * Score indicating low cognitive functioning on the Telephone Interview for Cognitive Status (TICS-m) assessment * Actively engaged in a weight loss program or unwilling to follow assigned dietary pattern * Unable to receive, store, or prepare food according to diet plan * Medical contraindication to either treatment or control diet (including severe allergies that cannot be accommodated within either group)

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Relapsing-remitting multiple sclerosis Secondary progressive multiple sclerosis

Contacts and locations

Locations

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • Washington University

    St Louis, Missouri, 63110, United States

More trials for these conditions

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