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Heart attack may spark brain inflammation, tiny study hints

NCT ID NCT03968445

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 2 times

Summary

This study uses a special PET/MRI scan with an investigational tracer called [18F]DPA-714 to see if a heart attack leads to inflammation in the brain. Researchers will compare 6 people who recently had a heart attack with a control group. The goal is to better understand the link between heart disease and brain health, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
[18F]DPA-714 (an imaging tracer)
What this could lead to
If successful, this could help researchers understand how heart attacks affect the brain and may point toward new ways to protect brain health after a heart attack.
What could go wrong
This is a very early, small study with only 6 participants. It is designed to observe, not treat, so it may not lead to any direct medical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

6 people

The number who actually took part.

Started

Oct 2019

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participation in UAB IRB protocol "Neuroinflammation After Acute Myocardial Infarction" (IRB-300002751, PI Lazar). 2. 21 years of age or older 3. . English speaking with at least 8th grade education 4. High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971. 5. Admission to UAB Hospital for ST-elevation acute myocardial infarction (AMI) and treatment with percutaneous coronary intervention (PCI) OR Undergoing elective percutaneous coronary intervention (PCI) Exclusion Criteria: 1. Contraindication to MRI 2. Pregnancy 3. Lactation 4. Serious medical co-morbidity that may interfere with participation 5. Prior myocardial infarction 6. Severe anemia 7. Prior coronary artery bypass grafting 8. Prior angioplasty and/or coronary artery stent placement (PCI group only) 9. History of traumatic head injury defined by a loss of consciousness ≥30 minutes or seizure at the time of injury 10. Diagnosis of major depression 11. Diagnosis of dementia 12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.

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Conditions

The condition(s) this trial relates to.

myocardial infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial infarction

Contacts and locations

Locations

  • University of Alabama at Birmingham Medical Center

    Birmingham, Alabama, 35294, United States

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