MYOCARDIAL INFARCTION

This study tests whether a drug called dapagliflozin (a type of SGLT2 inhibitor) can reduce the amount of heart muscle damage in people having a severe heart attack known as STEMI. About 256 participants will receive either the drug or a placebo right before emergency treatment. …

This study looks at whether using less of the drug noradrenaline by aiming for a lower blood pressure (≥55 mmHg) can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults who have had a heart attack and are in sh…

This study tests a new heart rehab program that combines telehealth sessions at home with some in-clinic visits, compared to the usual all-clinic program. The goal is to see if the hybrid approach helps more people stick with rehab and improve their ability to walk and exercise. …

This study tests whether a quick genetic test can help doctors choose a safer blood thinner for people who have had a heart attack. About 2,468 participants at high risk of bleeding will either get a standard strong blood thinner or a milder one chosen based on their genes. The g…

This study looks at two ways to deliver cardiac rehabilitation—a program of exercise, education, and counseling for people with heart conditions. One method is in-person at a clinic, the other is done remotely via telehealth. The goal is to see if both approaches are equally effe…

This study tests whether giving the cholesterol-lowering drug inclisiran soon after a heart attack can reduce the risk of another heart attack, stroke, or related hospital stay. About 300 adults in Russia who had a heart attack and have high cholesterol will receive inclisiran ea…

This study tests whether using only the blood thinner ticagrelor (instead of the usual aspirin plus ticagrelor) can lower bleeding risks in people who had a heart attack but did not get stents or bypass surgery. About 2,570 adults will be followed for 12 months to see if the sing…

This study tests a new stomach acid-reducing drug (tegoprazan) against a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners. The goal is to see if the new drug is as good at preventing serious stomach problems like bleeding and ulcers. Participants t…

This study looks at whether people who have had a heart attack but do not have heart failure can safely stop taking beta-blockers after at least one year. About 2,540 adults will be randomly assigned to either stop or continue the medication. The goal is to see if stopping is jus…

This study tests whether two drugs, colchicine and ticagrelor, can reduce inflammation and lower the risk of another stroke or heart attack in people who have already had a stroke. About 2,800 high-risk participants will take these medications alongside standard care. The goal is…

This study tests a noninvasive radiation treatment for ventricular tachycardia (VT), a dangerous heart rhythm that can cause sudden death. It is for 12 people with heart disease who have not been helped by standard treatments like medication or catheter ablation. The approach use…

This study tests a medicine called Xolatryp in adults who have had a severe type of heart attack (STEMI) and are getting a procedure to open the blocked artery. Participants receive either Xolatryp or a placebo as a one-time IV infusion over 6 hours. The study checks if the drug …

This study tests whether a new medicine called ziltivekimab can reduce plaque buildup in heart arteries after a heart attack. About 332 adults who recently had a heart attack will receive either ziltivekimab or a placebo for 15 months. Researchers will use special imaging to meas…

This study tests a new way to reduce heart damage in people having a severe heart attack (STEMI). When blood flow is restored to the heart, it can cause additional injury. Researchers are cooling the heart's arteries during the procedure to see if this limits that damage. The tri…

This study tests a new imaging test (PET-CT scan) that can see blood clots in the heart arteries from outside the body. The goal is to better identify what caused a heart attack, so patients get the right treatment. Researchers will recruit 80 adults who recently had a heart atta…

This study is testing whether a new smartphone-based 12-lead ECG device can accurately diagnose heart attacks (STEMI and NSTEMI) compared to standard hospital ECG machines. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to see if the por…

This study tests a new, noninvasive technique called magnetocardiography (MCG) to see if it can accurately identify heart attacks. Researchers will enroll about 3,800 healthy volunteers and people with chest pain. They will compare MCG results with standard tests like EKGs and bl…

This study looks at whether heart attack survivors with weak hearts can do just as well with modern medications alone compared to getting a defibrillator implant. About 3,600 participants who have had a heart attack and have a weak heart pump will be randomly assigned to either g…

This study looks at whether using a handheld stress management device called CalmiGo, along with usual cardiac rehab, can improve blood vessel health and lower stress in people who recently had a heart attack. About 100 adults will use the device for 12 weeks and have their blood…

This study tests whether a therapy called EMDR can reduce PTSD symptoms in 60 adults who developed PTSD after a heart attack. Participants will receive EMDR, and researchers will measure PTSD levels and stress responses at 3 and 6 months. The goal is to see if treating PTSD can a…

This study tests whether a home-based exercise plan delivered through a digital health app can help sedentary heart attack survivors overcome fear of movement (kinesiophobia) and improve their physical function. Researchers will enroll 88 people who had a heart attack at least 3 …

This study tests a device called Bioboosti that uses pulsed electromagnetic waves to see if it can improve blood flow to the heart in people with coronary artery disease. About 120 adults who have heart ischemia and cannot have standard procedures like stents or bypass will recei…

This study uses a special MRI technique to look at the microscopic structure of the heart muscle in people at risk for heart failure. Researchers want to understand how heart muscle fibers change over time in conditions like heart attack and thickened heart walls. The goal is to …

This study follows 100 people who had a heart attack to see how many develop anxiety or posttraumatic stress disorder (PTSD) later. Researchers want to understand if the fear, stress, and pain experienced during the heart attack play a role. Participants are adults aged 19–90 wit…

This study will follow 20,000 people who had a heart attack and were discharged early from the hospital. Researchers want to see how well their medications are adjusted, how many have another heart event, and how their quality of life changes over a year. The goal is to learn wha…

This study is creating a registry of 3000 people who had a heart attack but no blocked arteries (called MINOCA). The goal is to learn more about this condition, improve diagnosis, and understand long-term outcomes. Participants will be followed over time to track symptoms and hea…

This study follows 15,000 adults aged 45 or older who are having same-day noncardiac surgery. The goal is to find out how often heart problems or other serious events happen after these procedures and what factors increase the risk. By tracking unplanned hospital visits and admis…

This study is for people who recently had a heart attack and usually drink a little alcohol. It will compare two groups: one that continues moderate drinking (1 drink a day for women, 2 for men) and one that mostly stops drinking for 3 months. The goal is to see if moderate drink…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to understand what factors lead to worse outcomes and to improve how doctors predict and manage these conditions. No new treatments or proc…

This study tests whether a special nurse-led education program helps people who have had a heart attack feel more confident managing their health. Participants will either receive standard care or extra support including personalized visits and educational materials. The goal is …

This study is building and testing a special coil for a new type of MRI machine to take clearer pictures of the heart. Researchers will compare the new scans with standard heart MRIs in 150 people, including healthy volunteers and those who have had a heart attack. The goal is to…

This study is looking at whether people with psoriasis have a higher risk of heart disease. Researchers will follow 1,000 adults with psoriasis, using heart scans and blood tests to find early warning signs. The goal is to better understand the link between psoriasis and heart pr…

This study looks at 1000 people with high cholesterol to see if using ultrasound scans of the neck and heart arteries can find more people at very high risk of a heart attack than the usual risk calculator (SCORE2). The goal is to see if imaging helps doctors decide who needs str…

This study collects blood from 350 people who have had a heart attack, plus some with stable heart disease, to examine how platelets behave. Researchers want to understand differences between men and women and what makes platelets more active. No new treatments are tested; the go…

This study tests a new imaging method to help doctors treat a dangerous heart rhythm called ventricular tachycardia (VT). VT happens when scar tissue in the heart creates an electrical "short circuit." Doctors use a procedure called catheter ablation to block that circuit, but cu…

This study follows 300 adults who have had a severe type of heart attack (STEMI) to discover new biological and imaging markers that can predict heart function and recovery. Researchers will collect blood samples and perform MRI scans over one year, and track patients' health for…

This study looks at why women often have worse outcomes than men after a heart attack. Researchers think it may be because women's hearts change shape more after the attack. They will follow 1650 adults who had their first heart attack, using imaging to track heart changes over a…

This study looks at people who had a heart attack but whose main heart arteries are not blocked. Researchers want to see if problems in the tiny blood vessels of the heart affect future health. 150 adults will be followed to track heart-related events like another heart attack or…

This study compares two ways of guiding heart artery treatment in people having a major heart attack. One method uses standard X-ray images (angiography), the other uses a more detailed light-based scan (OCT). The goal is to see which approach leads to fewer heart-related problem…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study looks at whether cholesterol tests taken during a heart attack hospital stay give reliable results. About 100 adults admitted for a heart attack will have their cholesterol checked at the start, two days later, and again 4-6 weeks after leaving the hospital. The goal i…