MYOCARDIAL INFARCTION

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study looks at whether repairing all blocked arteries (guided by blood flow tests) is better than only fixing the main one in elderly heart attack patients aged 75 and older. About 1,445 participants are being followed to see which approach reduces the risk of death, another…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6000 adults hospitalized for a heart attack took part. The drug is added to stan…

This study tracks over 1,300 heart attack patients who received a procedure called PCI (angioplasty with stents) to open blocked arteries. Researchers are checking how well it works and how safe it is by watching for problems like bleeding, repeat heart attacks, or death. The goa…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable angina. The treatment uses a balloon to freeze high-risk plaque in heart arteries, aiming to make it stable and less likely to cause a future heart attack. About 30 participants…

This study is testing whether adding dried bilberries and oat bran to standard treatment can lower LDL cholesterol and improve exercise capacity in 900 adults with type 2 diabetes or a recent heart attack. Participants take the supplements for three months, and researchers measur…

This study compares two imaging methods to guide treatment of non-emergency blockages in heart attack patients who have multiple blocked arteries. About 1,800 participants will be randomly assigned to either a new angiography-derived blood flow measurement or standard angiography…

This study compares a new method for diagnosing heart attacks—focusing on whether a coronary artery is fully blocked (occlusion) or not—to the standard ST-elevation approach. Researchers will enroll 6,000 adults with suspected heart attacks to see if the new method better predict…

This study tests a new PET heart scan that uses 10 to 100 times less radiation than current methods. It involves 200 adults with known or suspected heart artery disease. Participants get a tiny dose of a radioactive tracer and are scanned for up to 3 hours to see if the images ar…

This study tests whether a special heart scan (dynamic SPECT) can accurately detect leftover blockages in heart attack survivors, compared to the current standard invasive test (FFR). About 60 adults with multiple blocked arteries will get both tests. If the scan works well, it c…

This study looks at 15 people who had a heart attack even though their arteries were not blocked. Researchers use special cameras to see inside the heart and arteries to find out what caused the attack. The goal is to learn more about this puzzling condition, not to test a new tr…

This study follows over 1,000 heart attack patients who received a stent to open blocked arteries. Researchers want to see how different outpatient rehab programs affect long-term health, including the risk of another heart attack, stroke, or need for more procedures. The goal is…

This study is gathering information from over 130,000 people who have had a heart attack or unstable chest pain. Researchers will look at treatments, outcomes, and genetic data to learn what works best. The goal is to help doctors and policymakers make better decisions for heart …

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study looks at 450 people who had a heart attack but no major blockages in their heart arteries. Using advanced imaging, researchers aim to find the real cause, like hidden plaque or tears. Participants are followed every 6 months for up to 10 years to track health outcomes.

This study looks at 2000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict who will develop heart failure, have another heart attack, or experience bleeding. Participants undergo extra tests like blood vessel st…

This study compares two drug-coated stents (SYNERGY and BioMatrix NeoFlex) used to open blocked heart arteries. Researchers will use a special camera to look at how the artery heals around the stent at one and three months after placement. The goal is to see which stent leads to …

This study looks at whether a new screening system can help doctors find heart complications early in patients who are at high risk after noncardiac surgery. About 900 adults aged 40-85 will be monitored with blood tests and checkups. The goal is to see if this approach is practi…

This study uses advanced PET/MRI scans to see if a heart attack triggers inflammation in the brain. Researchers will compare 6 participants who recently had a heart attack with a control group. The goal is to better understand how heart disease affects the brain and to guide futu…

This study tests whether a smartphone app that analyzes your voice can spot signs of anxiety and depression in people recovering from a heart attack. About 200 adults in cardiac rehab will use the app alongside standard care. The goal is to see if voice analysis can help improve …

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study tests whether giving doctors a special risk score—one that combines a person's genes with things like cholesterol and age—helps them make better decisions to prevent heart disease. About 1,000 people at moderate risk for heart disease but who have never had a heart att…

This study follows 1,599 people who had their first heart attack to see how the heart's shape and function change over time. Researchers want to understand which patterns of remodeling lead to heart failure. Participants are from several Minnesota counties and are not receiving a…